Although on the surface the three Lupo brothers seem like a trio of handsome Italian gents heading up a popular pizzeria in Pineview, Florida, the brothers in fact are concealing a deep, dark secret that disguises their true natures. Though charming and good-natured ladies' men by day, the trio rules the night in the form of mighty and empowered supernatural werewolves.
Determined to keep their secret in a world that fails to understand them, they find their privacy - and their very lives - at risk when an evil and nefarious werewolf hunter targets them for destruction. Tobias Barker makes it his mission to destroy Alessandro, Amedeo, and Randolph.
As Tobias finds his mission threatened by his own daughter, the powerful Isabella, Amedeo finally finds love with tough, sassy P. R. agent Samantha Bryant - a love that becomes threatened when Tobias arrives to destroy them all.