Lifespan

Why We Age—and Why We Don't Have To

De: David Sinclair, Matthew D. LaPlante

Narrado por: David Sinclair

Audio Bonus! Includes exclusive conversations with the authors!

A NEW YORK TIMES BESTSELLER
“Brilliant and enthralling.”​ —The Wall Street Journal

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Great research with unneed opinions not related.

i really liked the information and working to apply applications where i can.
the research was very informative. As long as he wrote information he researching it was great, but near the end he dove off into politics and other liberal
chatter is where i was disappoint. i dont need your opinion or areas you dont research included. Stick to the research, leave the liberal BS out of future books.

A+ on the Science. D on the Pontificating

The science segments were fantastic! Even when they were over my head, they were still great to hear. The author does a great job reading his work. The first 1/3 of this had me locked in. I couldn't stop listening. Then came the pontificating, the social engineering, the critique of everything from climate change, to plastics. The only subject I can't recall hearing an opinion on was abortion. While the author returned to science enough to keep me listening I couldn't help but gag when he would link the end of aging with rising ocean levels that I still have yet to see in San Francisco. In over 40 years, Fisherman's Wharf hasn't sunk. Except for political excursions, I found the book to be excellent.

Hope for the journey

I'm a 59 year old female. Middle class. Normal wear and tear and no diseases to speak of. I eat really clean; mostly whole foods, fewer carbs, much less sugar. I take care of myself pretty well, seeking traditional and holistic therapies to enhance my body, mind and spirit. No prescribed medications. I exercise.
The "normal wear and tear", however.....
I've thought often enough to myself over the past 5 years, as my knees have given way and my energy has waned and arthritis in my hands and fingers and feet have reared up, that surely it isn't downhill from this point. I get to look forward to greater pain and impeded mobility before knee replacements and recovery and if I'm super lucky, the same for my hips. I will move less and less and with less vigor. I will seek reasons why I cannot engage and "play". With a modest lifespan of 80+ then there are 20+ years left to feel kind of crappy. I rise to occasions but the joy in movement and feeling "alive" are diminished. It makes me sad.
My husband and I both have spoken a goal of living to 100. We have a wonderful family and grandchildren and we have personal goals for experiences and travel. But I can see how my current trajectory will undermine these goals.
Dr. Mark Hyman's podcast introduced me to biologist David Sinclair. I have just completed listening (and taking notes) to the Audible book. Mr. Sinclair has a wonderful ability to make this science of aging perfectly accessible and his stories weave it all together cohesively. I was most struck by the testimony of his father, however.
I take heart that this research is being done and is coming soon to a pharmacy near me. In the meantime, however, I have just started taking NR. I plan to incorporate other suggestions from his research and personal protocols as I am able. I look forward to noting any differences that may come my way, and bring me hope.

Great science, but a bit……

I enjoyed the science, but his arguments against those who hold a position against federally funded EMBRYONIC stem cell research were off putting.

He did not mention the distinction between stem cells obtained from arguably unethical means (abortion) and stem cells obtained from other sources.

Other than that, this book is outstanding. Well researched and thought out and explained. The science is sound, and I enjoyed it a great deal.

Bravo!

I appreciate the time Sinclair has taken out of his busy life to get this information out into the world. I also appreciate the forward thinking, and the sensible discussions he's brought forth. I think this book should give you the biggest incentive to take care of yourself. I'm 26, and one of the leaders of the Dept. of Genetics at Harvard Medical School thinks that I (in general) have a great chance to live until I'm 120. I literally quit smoking after I read this, and my wife is working on it. We're two people. I cannot imagine the number of lives this knowledge will change. I am grateful to live in this age. In this age of information, it is important to gather your knowledge from revered sources like David Sinclair PhD!