Super Agers

De: Eric Topol

Narrado por: Eric Topol

Super Agers is a detailed guide to a revolution transforming human longevity. This is a breakthrough moment in the history of human health care. The person making that bold claim is one of the most respected medical researchers in the world, Eric Topol.

Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving. He explains the power of the new approaches to the worst chronic killers—diabetes/obesity, heart disease, cancer, and neurodegeneration—and how treatments can begin long before middle age, and even long after. In thirty years, we will have five times as many people at least one hundred years old and they will be healthier than ever because of the breakthroughs Dr. Topol describes.

The amazing discoveries Topol brings into sharp focus are deeply inspiring about our human potential. We can now realistically see how we can make considerable headway for preventing age-related diseases and may one day be able to slow the body-wide aging process itself.

PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.

©2025 Eric Topol (P)2025 Simon & Schuster Audio

Reseñas de la Crítica

"Super Agers captures the extraordinary potential of today’s biomedical revolution. With breakthroughs like CRISPR genome editing and AI intersecting and accelerating at a remarkable pace, we stand at the threshold of preventing age-related diseases and unlocking new possibilities for longevity. Eric Topol's optimistic and inspiring vision makes this book an essential guide to the future of health."—Jennifer Doudna, Nobel Laureate, CRISPR gene editing co-inventor, and Innovative Genomics Institute founder

"For those looking for simple slogans or short videos to guide them to long life, they will not find it in Dr. Topol's Super Agers! Instead, they will get a detailed, evidence-based and optimistic dose of the truth. The combination of genes, biology, behavior and environment, when subjected to the forces of computation linked to AI, reveal a picture of wondrous complexity of the human condition. The good news is that real progress is being made and that Dr. Topol's gift for expression of complex issues in useful language comes through again."—Robert Califf, former commissioner of the FDA

“Eric Topol is not only a distinguished geneticist, cardiologist, and scientist: he is the most widely read and credible health 'futurist' I know. Super Agers is a highly readable and evidence-based digest of those astonishing advances in medicine, science, and technology that directly affect our lifespans. In its pages is a roadmap for linking your own measurable data with personalized actions and interventions that improve your odds of living longer, and more importantly, doing so in good health. Super Agers is a landmark book."—Abraham Verghese, author of The Covenant of Water

Strong belief in multimodal AI and risk prediction and medicine based longevity

As a medical doctor and PhD student, I found this book conceptually overstretched and methodologically incoherent. The author oscillates between randomized trials, observational epidemiology, and animal models without acknowledging their vast differences in causal inference or external validity. This undermines the credibility of his arguments.

More critically, I challenge the foundational assumption that more accurate individual risk prediction will meaningfully improve health outcomes. Everyone is “at risk” for chronic diseases—cardiovascular, metabolic, neurodegenerative, and cancer. Informing people about elevated risk has shown, at best, marginal impact on long-term behaviour. The idea that personalized risk information will drive population-level health improvement is not supported by empirical evidence and overestimates the rational actor model of human behavior.

Leading Edge Summary on Medical Research on Aging

This was a very fast listen. Each chapter brings you up to the various categories of research on aging. Dr. Topol explains things in a even tempered, nonadvocative and educational manner that helps the lay person understand where we are on the topic of aging. You will not be disappointed.

Brilliant work highlighting the advances of geroscience

Super Agers is an excellent book, thank you Dr Eric Topol for narrating the audible version and including the 74 page reference with notable figures and diagrams. Well done!

A Dense but Illuminating Map to Longer, Healthier Lives

In Super Agers, renowned cardiologist Eric Topol offers a sweeping, densely packed guide to the evolving science of longevity. Topol’s central mission is clear: to show how modern medicine—bolstered by genomics, pharmacology, and AI—may allow many of us not simply to live longer, but to delay the onset of chronic disease and enjoy an extended healthspan.

The book brims with valuable, up-to-the-minute insights, yet prospective readers should be forewarned: Super Agers is no breezy popular science title. Large sections read more like rigorous academic reviews than general-interest prose. Topol marshals hundreds of studies and showers the reader with specialized terminology, technical data, and acronyms, many of which would likely bewilder even the most diligent, college-educated audience. Skimming, rather than savoring, may become a survival strategy for many readers.

Given Topol’s professional roots, it is no surprise that his discussion of cardiovascular disease prevention is among the book’s strongest and clearest contributions. By contrast, the opening to Chapter 6, which addresses cancer, is strikingly disjointed—an odd lapse in an otherwise meticulously constructed narrative.

Among the most revelatory sections is Topol’s exploration of GLP-1 receptor agonists, a class of drugs already famous for their role in diabetes and obesity treatment. Topol convincingly argues that their potential impact extends much further, suggesting they may reshape the landscape of medicine itself. “The impact of GLP-1 drugs in medicine—for improving patient outcomes—will likely be more substantial than any prior class of medications,” he writes, noting their “major triumph” in combining high efficacy with favorable safety profiles. At one point, Topol even speculates that “it is conceivable that most people will be taking one of the GLP-1 drugs in the future.” It’s a bold assertion, but one he supports with considerable evidence.

Topol’s scholarly rigor is reinforced by an exhaustive list of references, although the unconventional note system—linking citations to chapter and page numbers rather than traditional footnotes—and the minuscule font size used for these notes are sure to frustrate anyone wishing to dive deeper without a magnifying glass.

The ultimate question, then, is: for whom was this book written? Despite its glossy cover and broad promises, Super Agers seems best suited to practicing physicians, researchers, and highly motivated lay readers with a tolerance for complexity. Those willing to persevere will be rewarded with a bracing, if at times arduous, journey through the cutting edge of preventive medicine.

Super Agers may not offer an easy path to a longer life, but it is a serious guide for those determined to understand—and perhaps seize—the promise of modern longevity science.

About survival

I can’t understand why this book doesn’t have a higher rating. Is it because people are trying so hard to amuse themselves? Certainly the information in this book is useful to help us prolong our Lives and live a better quality of life while doing so. I suppose that means I will be able to read more books that amuse me after I finish the survival part.

I am not sure why, but none of the platforms where I am able to read this book offer any instruction about how to download the PDF file that Dr. Topol is constantly referring to. I will keep trying to find it because it sounds interesting.

Old outdated studies … don’t bother to listen

Old outdated studies based on NIH and other such research that are tainted by the interest groups. Hard to listen to…nothing new but old and outdated info … would return if I could!

Title not indicative of content

Most of this book was like listening to a lecture for biomedical researchers and very little was actually about Super Agers. Yes the lifestyle + part was interesting but the rest was really hard to listen to. I slogged through the whole book but it was boring and hard to follow.

Nothing New, Move Along

This book contains nothing new. Eat more vegetables, avoid meat, avoid ultra processed foods, Mediterranean diet is great. Nothing we haven't heard ten thousand times in the last ten years. It's really a regurgitation of Dr. Micheal Gregor's How Not To Die with a much shallower dive into the details of the studies, who funded them, etc.. The doctor's voice is a bit monotonous and sleepy. Don't get me wrong the information is legit. It's just nothing new and not delivered in an exciting way.

Dogmatic nonsense

This book is of regurgitation of the dogma that has us in our current health situation. Everything is viewed through the lens of pharmaceutical intervention. No discussion of meaning regarding root causes, and how to treat root causes. This old way of thinking, reminds me of the saying, Medical advancement proceeds one funeral at a time. It’s time for this book to be buried.