Francesca and Sarah Hollister are learning the ropes as the newest members of the PBI (Paranormal Bureau of Investigation), and being a supernatural agent and a forensic expert is not as glamorous as they once thought. Frankie learns that things are far more dangerous in the field than she ever imagined, and Sarah realizes her co-workers aren't very happy she's on the team.
When an attack leaves Devon on the mend, Frankie is sent in to help Jasmine and Fang on a case of human cannibalism in Florida. The team realizes the perpetrator isn't a wendigo, but his ailment is far more dangerous, and the PBI team offers to help find a cure. In the transporting process one of the team members is infected with the deadly virus and the PBI team's world explodes from there.