Henry and Samantha struggle against a town to save a family from typhoid fever. The townspeople refuse to help and openly threaten Henry. Ice is the major commodity needed to keep the fevers down, and little is available in town. Samantha volunteers to go to the nearby mountains and bring ice down in her wagon with the help of a local mountain man.
The pair meet up with disastrous consequences in the mountains, when it appears there is no ice. Meanwhile, Henry's ability to curb the potential epidemic is failing. As the fever spreads from different quarters, Henry is hard pressed to find the real source of the disease.