Fourth-year medical student Demetri Makropolis has been assigned to cover orthopedics at Eastside Medical Center, one of New York City's finest hospitals. Just as his surgery team begins to operate on New York's leading drama critic, F. J. Pervis III, the patient suddenly goes into cardiac arrest. The team fails to resuscitate him, so the corpse is moved to the hospital's morgue. But before the autopsy is even performed, the body vanishes from the morgue and mysteriously reappears a day later - with the brain surgically removed.
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