• 82. Microbiome 2: Microbiotoxicity
    Jun 17 2024

    In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity!

    This episode is part 2 of 2. Here we discuss:

    - What is microbiotoxicity?
    - Risk factors for microbiotoxicity
    - Which antibiotics are associated with microbiotoxicity?
    - Mitigating microbiotoxicity

    https://www.researchgate.net/profile/Anastasia-Theodosiou

    https://x.com/doctoranastasia

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    45 mins
  • 81. Microbiome 1: Introduction
    Jun 3 2024

    In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject!

    This episode is part 1 of 2. Here we discuss:
    - What is the microbiome
    - Viewing the microbiome as an organ system
    - The microbiome's association with disease
    - How we study the microbiome

    Stay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your patients' microbiomes in tip top shape!

    https://www.researchgate.net/profile/Anastasia-Theodosiou

    https://x.com/doctoranastasia

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    30 mins
  • 80. A Poem on POET
    May 20 2024

    Join us for this special 80th episode celebrating Jame's favourite trial.

    https://www.nejm.org/doi/full/10.1056/NEJMoa1808312

    Prep notes (including the images referred to in the poem) here.

    Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on.

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    6 mins
  • 79. A Précis on Penicillin Binding Proteins
    May 6 2024
    Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know!

    • What is the difference between Gram positive and negative bacteria's cell walls?
    • What is a Penicillin Binding Protein (PBP)?
    • Why are they called PBPs?
    • What do PBPs do?
    • What makes MRSA resistant to (most) beta-lactams?
    These any many more questions answered!

    Notion page here - you'll need it for this one, check it out!

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    33 mins
  • 78. Pharmacokinetics summary
    Apr 21 2024

    One PK table to rule them all
    One table to find them
    One table to bring them all
    And in the darkness blind them…

    …with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike!

    Prep notes here.

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    26 mins
  • 77. Illuminating Elimination
    Apr 8 2024

    The last Pharmacokinetics episode had finally been …Excreted!

    This episode covers the ‘drug out’ bit of pharmacokinetics, including things such as:

    -What is clearance?
    -how to calculate half life
    and
    -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).

    Check out our prep notes (including for this episode) here.

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    43 mins
  • 76. Dithering on distribution
    Mar 24 2024

    It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification).

    What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here.

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    41 mins
  • 75.Blethering about Bioavailability
    Mar 11 2024

    It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice.

    Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here.

    Support the Show.

    Questions, comments, suggestions to idiotspodcasting@gmail.com or on X/Threads @IDiots_pod

    Prep notes for completed episodes can be found here (Not all episodes have prep notes).

    If you are enjoying the podcast please leave a review on your preferred podcast app!

    Feel like giving back? Donations of caffeine gratefully received!
    https://www.buymeacoffee.com/idiotspod

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    41 mins