The first of two Conference Highlight specials from the Advanced Prostate Cancer Consensus Conference, held in April 2024 in Lugano. This is our very favourite prostate cancer meeting and we are thrilled to bring you these highlight podcasts. In this epsiode we chat with Silke Gillessen, Derya Tilki, Jochen Walz, Neha Vapiwala, Dingwei Ye, and the lucky trainees who won a GU Cast Travel Award to attend this year's APCCC.

GU Cast Conference Highlights are supported by our friends at Bayer China, Gold Partners of GU Cast.

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Didn't get to ASCO this year?? Us neither!! But not to worry, we checked in with Dr Marty Schoen who did, and brings us all the key highlights! Marty is a GU Medical Oncologist at the St Louis Veterans Affairs Medical Centre and the University of St Louis, Missouri. He runs through a smattering of stuff that caught his eye at ASCO this year. Thanks Marty!

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For Urologists, there are not that many papers that come along where we can say - "this will almost immediately change my practice". But KEYNOTE-564 looks like one of those! A large phase III randomised trial of adjuvant pembro following nephrectomy for renal cell carcinoma in patients deemed at higher risk for recurrence. Regular listeners/viewers might remember we discussed this on GU Cast back in August 2021 when the disease-free survival endpoint was published in NEJM, and it would be fair to say we were cautious and kept saying "we need to wait for the overall survival data". Well here we are! Patients who received pembro for one year had a 38% reduced risk of death. Big news!

We are joined again by Dr Alex Kutikov, Urologist at Fox Chase Cancer Centre, who joined us on the original podcast. We are also joined by his colleague GU Medical Oncologist, Dr Matt Zibelman, who has a lot of experience in this area having been an investigator on the IMmotion 010 study. Unfortunately lead author Dr Toni Choueiri could not join us this time but he gets plenty of mentions!

This is a Themed Podcast supported by our Silver Partners, MSD, manufacturers of pembrolizomab, through an educational grant. MSD had no input into the content of this podcast.

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Links:
Full NEJM paper
Previous GU Cast on K-564

Should we remove bladder cancers piece-meal by chopping them into little pieces, or should we try and remove en bloc with a margin around the base?? This very nice randomised controlled trial from our friends in Hong Kong demonstrates that the recurrence rate is significantly lower if we use the all-too-rarely used en bloc technique. Dr Jeremy Teoh from the Chinese University Hong Kong joins us to discuss his paper just published in European Urology.
Check out the YouTube version for a video of the technique.

Also available as an audio only podcast wherever you get your podcasts

Full paper here

Today we have Dr Alicia Morgans, GU Medical Oncologist and Director of Survivorship at Dana Farber Cancer Institute, in the GU Cast studio for a chat. We wanted to ask Alicia to look forward and identify three big challenges we will face in metastatic prostate cancer over the next 5-10 years. What did we come up with??!! Tune in to find out!!

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In the first of our special episodes focussing on GU Oncology in China, we are delighted to welcome our inaugural GU Cast China Editor. Professor Yao Zhu, to the GU Cast studio. Yao is a Urologist at Fudan University Shanghai Cancer Centre, and is well known to all of us at GU Cast and Peter MacCallum Cancer Centre. As part of our Gold Partnership with Bayer Pharmaceuticals in China, Yao will help us put together some Themed Podcasts focussing on GU Oncology in China.
This first episode focuses on one of our favourite topics, metastatic hormone-sensitive prostate cancer (mHSPC). We chat with Yao and special guest, Professor Ning Zhang (Beijing Anzhen Hospital, affiliated to Capital Medical University), and learn a lot about prostate cancer in China!
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Great fun on the shores of Lake Lugano where the hosts of three of the best
-known podcasts in GU Oncology get together for a chat! Declan and Renu from GU Cast, join with Brian and Tom from Uromigos, and Gill from Oncoalert. How did it all start? Why did it all start?! Best moments, worst moments etc.
Tune if for a chat, and do please subscribe/like/follow all of us! Just search GU Cast/Uromigos/Oncoalert wherever you get your podcasts

The 2nd ProsTIC Preceptorship is one of the most intense fora for the discussion of PSMA theranostics anywhere in the world! A biennial meeting in Melbourne with many of the world's leading experts in the field. Not just superb practical advice about how to get your prostate cancer theranostics program to the next level, but some amazing discussions on where to next for theranostics in prostate cancer. Plus, watch out for the shenanigans at the conference dinner!
Our Conference Highlights are supported by our friends at Bayer China.
Even better on our YouTube channel