Regular price: $20.99

Free with 30-day trial
Membership details Membership details
  • A 30-day trial plus your first audiobook, free
  • 1 credit/month after trial – good for any book, any price
  • Easy exchanges – swap any book you don’t love
  • Keep your audiobooks, even if you cancel
  • After your trial, Audible is just $14.95/month
OR
In Cart

Publisher's Summary

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.

What these strange conditions, including fatal familial insomnia, kuru, scrapie, and mad cow disease, share is their cause: prions. Prions are ordinary proteins that sometimes "go wrong", resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA. And the diseases they bring are now spreading around the world.

In The Family That Couldn't Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion's hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story's connection to human greed and ambition, from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out.

The biologists who have investigated these afflictions are just as extraordinary. They include Daniel Carleton Gajdusek, a self-described "pedagogic pedophiliac pediatrician" who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.

©2006 D.T. Max; (P)2006 Tantor Media, Inc.

Critic Reviews

"Very timely and compellingly written." (Booklist)

What members say

Average Customer Ratings

Overall

  • 4.1 out of 5.0
  • 5 Stars
    127
  • 4 Stars
    136
  • 3 Stars
    53
  • 2 Stars
    12
  • 1 Stars
    8

Performance

  • 4.2 out of 5.0
  • 5 Stars
    61
  • 4 Stars
    60
  • 3 Stars
    19
  • 2 Stars
    3
  • 1 Stars
    2

Story

  • 4.4 out of 5.0
  • 5 Stars
    75
  • 4 Stars
    56
  • 3 Stars
    13
  • 2 Stars
    2
  • 1 Stars
    2
Sort by:
  • Overall
  • Performance
  • Story
  • David
  • Ithaca, NY, USA
  • 11-04-06

A great scientific mystery

This has become one of my favorite non-fiction books on audible. If you enjoyed "Splendid Solution", "The Great Influenza" or "Germs" you will love this one. It may not have the humor or entertainment value of "The Omnivore's Delimma" but the author does a fine job of weaving personal stories with science to create a fascinating story. This is a great introduction to Mad Cow and other prion diseases, and also provides a distrubing account of how governments bumble their way through such outbreaks.

Grover Gardner also performs another excellent reading. In my opinion, Gardner is by far the top narrator for any material that has any scientific or technical content. His voice moves gracefully over the text - always with the right nuance and pronunciation - allowing the listener to become quite captivated by the story.

15 of 16 people found this review helpful

  • Overall
  • Bibi
  • Eagle River, AK, United States
  • 03-24-10

Very entertaining and enlightening

Wonderfully written account of prions: the diseases associated with them; the nobel laureates who study them; people affected; and how the problem began, was discovered, and has spread. Like a PBS special and a novel rolled into one, you learn quite a bit while being thoroughly entertained. A page turner.

5 of 5 people found this review helpful

  • Overall
  • Jennifer
  • Hudson, WI, United States
  • 05-27-09

Quite informative

I know others have put down this book because it isn't just about the life of the family that couldn't sleep. True, it is a book about prions, and tells of all of the research in many fields and into many disorders. But, scientific though it is, it really is facinating and quite easy to follow along with and understand. The reader does have a bit of an annoying habit of ending every sentence the same way with a strange inflection, but you'll get used to it, or at least learn to ignore it.

3 of 3 people found this review helpful

  • Overall
  • Performance
  • Story

a fatal insomnia

Where does The Family That Couldn't Sleep rank among all the audiobooks you’ve listened to so far?

among the top books i have listened to on audible

What other book might you compare The Family That Couldn't Sleep to and why?

epigenetics

What about Grover Gardner’s performance did you like?

well researched, up to date, and narratives that bring you to understand the lives affected by those afflicted with prion disease.

If you were to make a film of this book, what would the tag line be?

a fatal insomnia

Any additional comments?

a unique historical perspective on a rare inherited genetic disorder that strikes its victims with symptoms of a lethal insomnia in their most productive years. Also, tied into this narrative of the familial disease, is its link to the prion disease of mad cow, or CJD. The research documented by D.T. Max, brings to light cases of individuals affected by CJD that has occurred in the U.S. and the U.K. which can only be explained prions from contaminated beef. That the threat still exists, and human cases are being suppressed by the USDA, should make anyone concerned about the potential impact of circulating prions in our beef supply.

2 of 2 people found this review helpful

  • Overall
  • Performance
  • Story
  • Pam James
  • Lawrence, KS United States
  • 08-24-13

Prion Drama

It is surprising how fascinating a medical mystery can be. I was hanging on every word. I was terrified, but still could not stop listening.

2 of 2 people found this review helpful

  • Overall
  • Performance
  • Story

Zombie science

I picked this right after starting the short-story anthology Zombies vs. Unicorns (zombie fiction sometimes blames prions) on Kindle. Fun connection. As to this book, it was a great story, interesting science, kept a good pace, and gave me pause (yet again) about eating factory-farm meat...

2 of 2 people found this review helpful

  • Overall

Fascinating

look into the frightening world or prion diseases.

2 of 2 people found this review helpful

  • Overall
  • Performance
  • Story

Yawn...!

I wouldn't say this was a terrible book. I would say it was a mediocre book. It was essentially a medical textbook and it read like one. I usually enjoy books about these subjects, but there was something about this book that I just can’t put my finger on that leaves me with this "it's just average" feeling. Yes, I did learn something, which I always enjoy, but you certainly need to pay attention to every single sentence in this book or you will be totally lost. It was very heavy on the science, but not so much that anyone with a decent public education couldn’t absorb. I usually find myself searching online while listening to books like this to learn even more about the subject, but this book just didn’t evoke that kind of interest for me.

The only saving grace is the narration. I think that is the only thing that kept me from returning the book at the halfway point. Grover Gardner made it worth holding out to the end; he’s just that good! I'm debating if I'll listen to this book again to see if my opinion changes?

Ironically, this book has discovered the cure for the Family That Couldn’t Sleep; they just need to listen to this book. Put me to sleep in about 10 minutes every night.

1 of 1 people found this review helpful

  • Overall
  • Performance
  • Story

Great book!

Well paced and scientific. A good deal of jargon and acronyms but that was what I was expecting. More like a history of prion disease with lots of case studies and history.

1 of 1 people found this review helpful

  • Overall
  • Performance
  • Story

Heart-wrenching medical challenges

Would you recommend this audiobook to a friend? If so, why?

Yes. The story is well researched and written in an engrossing style. Medical mysteries and detective work are as fascinating as any other sort of story, real or fictional. The author, D. T. Max, suffers from one form of misfolded proteins that impair nerve transmission to his muscles. In researching his own little understood condition, Max interviewed members of an Italian family prone to develop fatal insomnia, an even more rare, inherited misfolded protein illness affecting very few families worldwide. Max also studied assorted prion diseases, usually contagious, sometimes possibly not, that have become known to the public in recent decades. Prions are misfolded proteins, similar to the causative problem in the author's syndrome. Prions cause, among other fatal illnesses, the so-called Mad Cow disease (bovine spongiform encephalopathy) and Creutzfeldt-Jakob disease (CJD.) This book reveals the difficulty researchers encountered in discerning the causes of these illnesses, the various governments that dealt poorly with reducing spread of contagion by prions, and the totally inadequate efforts that are being made towards treatment and cures.

Who was your favorite character and why?

This is not a book centered on characters, though many fascinating and very special people are described.

Which character – as performed by Grover Gardner – was your favorite?

Again, not pertinent. Gardner's narration was well paced and suited the material.

Was this a book you wanted to listen to all in one sitting?

Yes, even though it is long and there is a great deal of data to absorb. I found the subject matter fascinating.

Any additional comments?

Anyone who likes medical mysteries would enjoy this book. But it is more than a story about discovery. Max's book makes it clear that we all face some degree of risk of contracting a fatal prion-based illness, thanks to the tendency of governments to allow exposure of the population to continue, out of fear of the negative economic impact that might occur or simply out of sheer hubris and denial. Equally alarming is the paucity of research into prevention, treatment and cures, since the number of affected people doesn't appear high enough to provide pharmaceutical companies with the incentive of making a profit. I foresee a time when there will be plenty of sufferers to prompt investment in finding ways to prevent and treat protein misfolding illnesses. That need not happen, if the curative effort is pursued sooner rather than later. I have taken care of two patients who suffered from CJD. Their ends were horrible and tragic. I hope for all our sakes that some intrepid researchers continue the fight against prions and other misfolded protein syndromes, so that our children don't have to deal with the heartbreak of such illness in their lives.

1 of 1 people found this review helpful