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A Crack in Creation Audiobook

A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution

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Publisher's Summary

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers and will help address the world's hunger crisis. Yet even the tiniest changes to DNA could have myriad unforeseeable consequences - to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create "better" humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?

©2017 Jennifer A. Doudna and Samuel H. Sternberg (P)2017 Audible, Inc.

What Members Say

Average Customer Rating

4.5 (190 )
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  •  
    Philomath 06-17-17
    Philomath 06-17-17 Member Since 2017
    HELPFUL VOTES
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    "In to the abyss we ascend, a scary future"
    Would you listen to A Crack in Creation again? Why?

    Probably not


    Who was your favorite character and why?

    n/a


    What about Erin Bennett’s performance did you like?

    Good


    Was there a moment in the book that particularly moved you?

    The whole idea shook me not just moved me


    Any additional comments?

    This book is a must read for everyone. Humanity is on the cusp of changing itself forever and most don't even know it.

    I will ignore the mistakes and unintended consequences of the fascinating CRISPR technology, which are scarier and more prevalent than any technology humans have ever created, and let's pretend everything goes as planned, a highly unlikely scenario.

    CRISPR technology is basically the editing of genes with what appears to be the at most accuracy, and it is easier and cheaper than pretty much any other important technology man has recently created.

    Creating a mouse that glows in the dark, a pig that is the size of a pet dog, a fish which grows legs are things that have already been achieved. Eliminating heritable disease will be next without a doubt, and what after that? Forget a pretty blue eyed child, or a tall muscular athlete, which I'm sure is coming to a theatre next to you soon.

    Let's use our imagination, a larger brain, more memory, more stamina, less sleep, high IQ, a human that has gills and can breath underwater and go down the near endless list of living DNA and pick your choice.

    At first glance I think, let this not happen, STOP it right now, then I realise the cat is out of the bag, Pandora's box has been opened. It is the ultimate weapon for domination that has all the hallmarks of Eugenics on steroids.

    To quote Steven Pinker let's hope "the better nature of our angels" evolves quickly enough to create future humans with compassion and tolerance. The author, probably a great scientist, is an optimist. I truly hope she's right, otherwise this could be a good explanation to Fermi's Paradox. This could potentially be the last mistake humankind makes. Since the next one if we are lucky will be made by an edited human animal that will need a new name.

    Fascinating, incredible and scary science, and not necessarily in this order. Highly recommended for those who want to be spooked.

    15 of 17 people found this review helpful
  •  
    DC Mike NoVA/DC 09-01-17
    DC Mike NoVA/DC 09-01-17 Member Since 2015
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    "An easily digestible intro to the future..."

    Maybe it was driven by my personal curiosity but I found this to be an excellent intro to a topic that I've only encountered in exaggerated news clips or poorly written internet blog ramblings.

    3 of 3 people found this review helpful
  •  
    JMcD 09-08-17
    JMcD 09-08-17
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    "a must read"

    wow... so glad you wrote this (and so glad I read it). thank you on so many levels

    2 of 2 people found this review helpful
  •  
    Laura 09-02-17
    Laura 09-02-17 Member Since 2016
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    "Compelling and eye opening!"

    I listened to a podcast on Crispr/Cas9 a few years ago. I wanted to build a greater understand if the technology. It's well written & designed for the non-scientist although I was grateful I paid attention in high school biology.

    2 of 2 people found this review helpful
  •  
    Mom of four Laurel, MD 06-24-17
    Mom of four Laurel, MD 06-24-17 Member Since 2013
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    "Balanced, insightful, pressing"

    Prof Doudna's insightful account of this rapidly developing capability -- along with its inherent impact on mankind -- is both balanced and pressing. Recommended and accessible to people of all walks of life. I was unaware of how far genetic engineering has advanced -- stunning, concerning, and inspirational -- all at the same time. IT'S A GREAT BOOK!

    8 of 10 people found this review helpful
  •  
    Amazon Customer 07-21-17 Member Since 2017
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    "If you can get past the dripping ego..."

    Okay. So the author is brilliant. That is not in question. However, prepare yourself to hear how "amazing" and "brilliant" nearly everyone is that she has come in contact. The story gets quite preachy at parts and has moments of borderline condescension. If you can put this aside, the science is interesting.

    19 of 25 people found this review helpful
  •  
    Amazon Customer 08-01-17 Member Since 2015
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    "Fantastic, and Enlightening!"

    This should be a must read for all who are concerned about the future of the human race. Prof Doudna and her collaborators should receive the Nobel prize for their genius and dedication .

    5 of 7 people found this review helpful
  •  
    Jan D. Leslie salem,nh usa 07-22-17
    Jan D. Leslie salem,nh usa 07-22-17 Member Since 2017
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    "Amazing"

    what a wonderful book. Enthusiastically describes an incredible new level of understanding. As well as how the tools that come with it can make all our genetic dreams, and nighmares, come true.

    5 of 8 people found this review helpful
  •  
    Dale 10-10-17
    Dale 10-10-17 Member Since 2010
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    "Need an advanced science degree"

    Very important information is contained in the book. But even with my advanced degree in science, I found the book hard to follow at times. Covered the political side well. Brought me up to day in being able to manipulate our DNA. Somewhere down the line gene editing will be a major step in treating disease. Gene editing will lead to significant cultural shifts. How soon and the nature of the cultural shifts, hard to say and not speculated in this book. The authors recommends going slow with this technology.

    0 of 0 people found this review helpful
  •  
    Mary S. Heider 10-06-17
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    "vital information for all to consider. through,"

    understood by the layman. Thank you. Because of listening, I have changed my opinion in favor of Gene editing with great care and ethical consideration.

    0 of 0 people found this review helpful
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  • M. Griffiths
    8/15/17
    Overall
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    "Gene editing introduction"

    From the horse's mouth, this book runs thru the discovery of truly transformational biology. Basic concepts are well explained for the uninitiated and the story is both incredibly important and interesting. The author's presentation of her work was not unlikeable and seemed fair - she has been accused of claiming all the credit.
    Why not 5 stars? It is a little repetitive and an accompanying pdf is invaluable for this type of book.

    0 of 0 people found this review helpful

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