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The Breakthrough
- Immunotherapy and the Race to Cure Cancer
- Narrated by: Will Collyer, Charles Graeber
- Length: 7 hrs and 7 mins
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Publisher's summary
Follow along as this New York Times best-selling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal).
For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses - tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment", a revolutionary discovery in our understanding of cancer and how to beat it.
In The Breakthrough, New York Times best-selling author of The Good Nurse Charles Graeber guides listeners through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of 21st-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step - harnessing the wealth of new information to create modern and more effective patient therapies - is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease.
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.
Critic reviews
"Graeber concisely reviews the science of cancer...The risks of tinkering with an intricate immune system are obviously high, even perilous. But the potential reward is a cure. Exciting reading." (Booklist)
"There is no villain more ruthless than cancer, which has robbed us all of loved ones who had to endure untold suffering before they succumbed. But after decades of frustration and toil, scientists finally understand how to vanquish the disease by activating the human body's natural defenses. The intimate stories behind this triumph lie at the heart of Charles Graeber's The Breakthrough, an expertly crafted and exhilarating account of life-saving ingenuity at its most dazzling. You will never encounter another book so incisive about the art of medical sleuthing, or so poetic about our innate drive to hold on to all that's beautiful in this world for as long as we can." (Brendan I. Koerner, Wired contributing editor and author of The Skies Belong to Us)
"[A] deft, detailed study of cancer immunotherapy.... From the once-discredited pioneer William Coley to immunologist and Nobel laureate James P. Allison, they form a brilliant, driven, admirably stubborn group that Graeber brings vividly to life." (Nature)
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Story
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible road map to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease.
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Non-fiction books - please include references
- By yaelb on 06-15-16
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
- By: Nathan Vardi
- Narrated by: Rob Shapiro
- Length: 8 hrs and 33 mins
- Unabridged
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For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
- By Anonymous User on 03-16-23
By: Nathan Vardi
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The Good Nurse
- A True Story of Medicine, Madness, and Murder
- By: Charles Graeber
- Narrated by: Will Collyer
- Length: 11 hrs and 35 mins
- Unabridged
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After his December 2003 arrest, registered nurse Charlie Cullen was quickly dubbed "The Angel of Death" by the media. But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.
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The Good Nurse gets it right
- By jc on 05-28-13
By: Charles Graeber
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Random Acts of Medicine
- The Hidden Forces That Sway Doctors, Impact Patients, and Shape Our Health
- By: Anupam B. Jena, Christopher Worsham
- Narrated by: Anupam B. Jena, Christopher Worsham
- Length: 9 hrs and 5 mins
- Unabridged
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As a University of Chicago–trained economist and Harvard medical school professor and doctor, Anupam Jena is uniquely equipped to answer these questions. And as a critical care doctor at Massachusetts General who researches health care policy, Christopher Worsham confronts their impact on the hospital’s sickest patients. In this singular work of science and medicine, Jena and Worsham show us how medicine really works, and its effect on all of us.
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Podcast is much better
- By R. Weilacher on 08-22-23
By: Anupam B. Jena, and others
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The Cancer Code
- A Revolutionary New Understanding of a Medical Mystery
- By: Dr. Jason Fung
- Narrated by: Brian Nishii
- Length: 10 hrs and 48 mins
- Unabridged
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Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline...but the “War on Cancer” has hardly been won. In The Cancer Code, Dr. Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease - what it is, how it manifests, and why it is so challenging to treat.
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Not helpful for a cancer patient
- By KattyG on 11-25-20
By: Dr. Jason Fung
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How to Starve Cancer
- ...And Then Kill It with Ferroptosis
- By: Jane McLelland
- Narrated by: Nano Nagle
- Length: 11 hrs and 47 mins
- Unabridged
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After being given a terminal diagnosis with only a few weeks to live, Jane McLelland dug up research, some decades old, in her quest to survive. Rather than aiming to cure cancer, which in many cases is unachievable, Jane's approach was to stop it growing. Remarkably, her approach not only stopped it growing, it disappeared altogether. There are now clinics following her protocol, achieving remarkable successes.
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Title if NOT accurate, Audio book is of Edition1
- By scott j on 01-21-24
By: Jane McLelland
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Superconvergence
- How the Genetics, Biotech, and AI Revolutions Will Transform our Lives, Work, and World
- By: Jamie Metzl
- Narrated by: James Anderson Foster, Jamie Metzl
- Length: 15 hrs and 44 mins
- Unabridged
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Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.
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Great Book Somewhat Spoiled by Self-Promotion
- By Jack E. Koepke on 06-22-24
By: Jamie Metzl
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Complications
- A Surgeon's Notes on an Imperfect Science
- By: Atul Gawande
- Narrated by: Robert Petkoff
- Length: 9 hrs and 31 mins
- Unabridged
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Sometimes in medicine the only way to know what is truly going on in a patient is to operate, to look inside with one's own eyes. This audio is exploratory surgery on medicine itself, laying bare a science not in its idealized form, but as it actually is - complicated, perplexing, and profoundly human. Atul Gawande offers an unflinching view from the scalpel's edge, where science is ambiguous, information is limited, the stakes are high. In dramatic and revealing stories of patients and doctors, he explores how deadly mistakes occur and why good surgeons go bad.
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FALLIBILITY, MYSTERY AND UNCERTAINTY
- By AnnH on 10-04-20
By: Atul Gawande
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The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- By: Walter Isaacson
- Narrated by: Kathe Mazur, Walter Isaacson
- Length: 16 hrs and 4 mins
- Unabridged
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The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
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Except for the author, this book is good!
- By Johan on 03-14-21
By: Walter Isaacson
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How Not to Die
- Discover the Foods Scientifically Proven to Prevent and Reverse Disease
- By: Michael Greger MD FACLM, Gene Stone
- Narrated by: Michael Greger MD FACLM
- Length: 17 hrs and 36 mins
- Unabridged
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The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives.
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A stunningly important book
- By Being on 12-29-15
By: Michael Greger MD FACLM, and others
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Outlive
- The Science and Art of Longevity
- By: Peter Attia MD, Bill Gifford - contributor
- Narrated by: Peter Attia MD
- Length: 17 hrs and 7 mins
- Unabridged
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Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health.
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Too Much Filler
- By J. Badaracco on 04-09-23
By: Peter Attia MD, and others
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Right Thing, Right Now
- Good Values. Good Character. Good Deeds.
- By: Ryan Holiday
- Narrated by: Ryan Holiday
- Length: 7 hrs and 59 mins
- Unabridged
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For the ancients, everything worth pursuing in life flowed from a strong sense of justice—or one’s commitment to doing the right thing, no matter how difficult. In order to be courageous, wise, and self-disciplined, one must begin with justice. The influence of the modern world often tells us that acting justly is optional. Holiday argues that that’s simply untrue—and the fact that so few people today have the strength to stand by their convictions explains much about why we’re so unhappy.
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Echoes left wing narratives
- By Jesse Williams on 07-02-24
By: Ryan Holiday
What listeners say about The Breakthrough
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- George Reid
- 03-03-19
Good intro to immunotherapy
great sequel to The Emperor of All Malidies. Same format great personal stories combined with solid explanations of the underlying science.
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1 person found this helpful
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- Bala
- 03-24-23
Starter Story on Immunotherapy
The Breakthrough: Immunotherapy and the Race to Cure Cancer by Charles Graeber is a well-written and informative book that tells the story of the scientific discoveries that have led to the development of immunotherapy, a new form of cancer treatment that is showing great promise. Graeber does an excellent job of explaining the science in a way that is easy to understand, and he also provides a balanced view of the potential benefits and risks of immunotherapy.
One of the strengths of the book is Graeber's ability to tell a compelling story. He profiles a number of patients who have been treated with immunotherapy, and he describes their experiences in vivid detail. This helps the reader to understand the human cost of cancer, and it also makes the science come alive.
Another strength of the book is Graeber's willingness to confront the difficult questions that immunotherapy raises. For example, he discusses the ethical implications of using the immune system to attack healthy cells, and he also raises concerns about the potential for immunotherapy to exacerbate racial disparities in healthcare.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
However, there are a few areas where the book could be improved. First, Graeber could have done a better job of explaining the technical aspects of immunotherapy. Some of the concepts he discusses are quite complex, and it would have been helpful if he had provided more detail.
Second, Graeber could have been more balanced in his coverage of the potential benefits and risks of immunotherapy. He tends to focus on the potential benefits, and he does not discuss the risks as extensively. This could give the reader a false impression of the risks of immunotherapy.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
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- Jenny
- 10-24-19
Inspiring + Informational Cancer Treatment Stories
I enjoyed listening to the history and science behind cancer research as well as all of the personal stories of struggle and progress. This gives me hope.
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- rafe
- 10-21-22
An excellent introduction for lay people into the world of immunotherapy for cancer treatment
If you enjoy learning about a range of subjects and have a high school level understanding of human biology, you'll find this book relatively easy to digest during the technical sections and all will find something that resonates with them in the stories of the cancer patients.
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- paul cochrane
- 04-11-24
Inspiring and informative
Will Collyer gives a top notch reading to a story, at once inspiring , and yet cautionary and hopeful.
It was also like an immunotherapy primer with a gripping tale.
After all, what is more gripping than real life.
Also my humblest thanks to those who dedicate themselves to finding solutions to this deadly disease!
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- Kari Niles
- 01-21-19
Surprisingly gripping
Take a scientific problem as vexing as cancer, come at it with an age-old yet controversial approach, and turn it over to a talented writer--one who uses simple metaphors to convey the complex, and who sprinkles in references to Jerry Garcia and Cassablanca just to keep you on your toes. The result? A fascinating medical tale that is still taking shape.
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15 people found this helpful
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- Bin Hu
- 12-01-19
A brief update of cancer therapy for the public
This book provides a few stories of successful and failed efforts in curing and managing cancer with immunotherapy. The narrative in the first chapter seems too emotional, almost like fiction, But later chapters turned out to be better. The book is easy to follow even for a layman and may be of interest to anyone who wants to follow the latest development of treating cancer.
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- Roy Jones
- 04-15-24
Current research on immunotherapy
chapter 1 had too many metaphors, like a dime store crime novel, and the turn to religion seems a slap in the face of the science developed to treat cancer
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- Tim S
- 08-20-19
Excellent
I read this after reading "The Emperor of all Maladies" It's an awesome add on. Well researched, written in an engaging way that keeps the listener locked in, but you will also learn a TON! I love books like this!
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1 person found this helpful
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- Merry Rogers
- 06-21-21
Well done
Well told story. The human side as well as the “breakthroughs.” I dislike any book on science which is dumbed down, personalized to opinion, or lacking data and source. This is not one of those.
Excellent.
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1 person found this helpful