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The Billion Dollar Molecule
- One Company's Quest for the Perfect Drug
- Narrado por: Stephen Bowlby
- Duración: 18 h y 25 m
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The Billion Dollar Molecule
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Resumen del Editor
Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.
Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating, no-holds-barred account of the business of science that includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
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- De: Jeffrey Kluger
- Narrado por: Michael Prichard
- Duración: 13 h y 12 m
- Versión completa
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General4.5 out of 5 stars 247
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Narración:4.5 out of 5 stars 150
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Historia4.5 out of 5 stars 152
Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program, and as humanity is tantalizingly close to eradicating polio worldwide, comes this unforgettable chronicle. Salk's work was an unparalleled achievement, and it makes for a magnificent listen.
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5 out of 5 stars
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Excellent book
- De Tim en 08-10-06
De: Jeffrey Kluger
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Polio
- An American Story
- De: David M. Oshinsky
- Narrado por: Jonathan Hogan
- Duración: 14 h y 37 m
- Versión completa
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General4.5 out of 5 stars 587
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Narración:4.5 out of 5 stars 418
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Historia4.5 out of 5 stars 417
This comprehensive and gripping narrative, which received the 2006 Pulitzer Prize for history, covers all the challenges, characters, and controversies in America's relentless struggle against polio. Funded by philanthropy and grassroots contributions, Salk's killed-virus vaccine (1954) and Sabin's live-virus vaccine (1961) began to eradicate this dreaded disease.
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5 out of 5 stars
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Wonderful
- De Patricia B Tripoli en 07-22-08
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How to Survive a Plague
- The Inside Story of How Citizens and Science Tamed AIDS
- De: David France
- Narrado por: Rory O'Malley
- Duración: 24 h y 28 m
- Versión completa
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General4.5 out of 5 stars 320
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Narración:4.5 out of 5 stars 297
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Historia4.5 out of 5 stars 296
A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments.
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5 out of 5 stars
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Read This Book!
- De Kay M Hawklee en 05-30-17
De: David France
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Tomorrowland
- Our Journey From Science Fiction to Science Fact
- De: Steven Kotler
- Narrado por: Tom Parks
- Duración: 8 h y 58 m
- Versión completa
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General4 out of 5 stars 428
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Narración:4.5 out of 5 stars 363
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Historia4 out of 5 stars 363
New York Times, Wired, Atlantic Monthly, Discover bestselling author Steven Kotler has written extensively about those pivotal moments when science fiction became science fact...and fundamentally reshaped the world. Now he gathers the best of his best, updated and expanded upon, to guide listeners on a mind-bending tour of the far frontier, and how these advances are radically transforming our lives.
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3 out of 5 stars
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Covers a lot of different topics in many industries
- De ErnieA en 06-27-15
De: Steven Kotler
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
- Versión completa
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General4.5 out of 5 stars 117
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Narración:4.5 out of 5 stars 100
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Historia4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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The Demon Under The Microscope
- De: Thomas Hager
- Narrado por: Stephen Hoye
- Duración: 12 h y 14 m
- Versión completa
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General4.5 out of 5 stars 3,481
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Narración:4.5 out of 5 stars 2,536
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Historia4.5 out of 5 stars 2,534
The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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5 out of 5 stars
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Great Book!!!!!
- De Amazon Customer en 05-21-08
De: Thomas Hager
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101 Theory Drive
- A Neuroscientist's Quest for Memory
- De: Terry McDermott
- Narrado por: Stephen Hoye
- Duración: 8 h y 55 m
- Versión completa
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General4 out of 5 stars 167
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Narración:4 out of 5 stars 63
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Historia4 out of 5 stars 65
It's not fiction: Gary Lynch is the real thing, the epitome of the rebel scientist - malnourished, contentious, inspiring, explosive, remarkably ambitious, consistently brilliant. He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain's memory machine has begun to pay off.
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5 out of 5 stars
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Pretty Dang Funny
- De Will en 05-14-10
De: Terry McDermott
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- De: Gregory Zuckerman
- Narrado por: Jack Armstrong
- Duración: 12 h y 6 m
- Versión completa
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General4.5 out of 5 stars 171
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Narración:4.5 out of 5 stars 145
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Historia4.5 out of 5 stars 144
Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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5 out of 5 stars
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Wow! Do not miss this one.
- De Jacob en 11-18-21
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Headstrong
- 52 Women Who Changed Science-and the World
- De: Rachel Swaby
- Narrado por: Lauren Fortgang
- Duración: 7 h y 1 m
- Versión completa
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General4 out of 5 stars 64
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Narración:4 out of 5 stars 54
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Historia4.5 out of 5 stars 54
In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation.
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4 out of 5 stars
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Role models for young women
- De mtsuda90 en 06-25-16
De: Rachel Swaby
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The Idea Factory
- Bell Labs and the Great Age of American Innovation
- De: Jon Gertner
- Narrado por: Chris Sorensen
- Duración: 17 h y 28 m
- Versión completa
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General4.5 out of 5 stars 990
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Narración:4.5 out of 5 stars 826
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Historia4.5 out of 5 stars 827
In The Idea Factory, New York Times Magazine writer Jon Gertner reveals how Bell Labs served as an incubator for scientific innovation from the 1920s through the1980s. In its heyday, Bell Labs boasted nearly 15,000 employees, 1200 of whom held PhDs and 13 of whom won Nobel Prizes. Thriving in a work environment that embraced new ideas, Bell Labs scientists introduced concepts that still propel many of today’s most exciting technologies.
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5 out of 5 stars
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Great story -- horrible pauses
- De Rodney en 01-29-13
De: Jon Gertner
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Sellout
- How Washington Gave Away America's Technological Soul, and One Man's Fight to Bring It Home
- De: Victoria Bruce
- Narrado por: Tom Parks
- Duración: 10 h y 44 m
- Versión completa
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General4.5 out of 5 stars 33
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Narración:4.5 out of 5 stars 33
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Historia4.5 out of 5 stars 33
American technological prowess used to be unrivaled. But because of globalization, and with the blessing of the US government, once proprietary materials, components, and technologies are increasingly commercialized outside the United States. Nowhere is this more dangerous than in China's monopoly of rare earth elements - materials that are essential for nearly all modern consumer goods, gadgets, and weapons systems.
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5 out of 5 stars
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Uncovering unsung heroes of modern America
- De Ben DeNardo en 08-24-17
De: Victoria Bruce
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No Better Time
- The Brief, Remarkable Life of Danny Lewin, the Genius Who Transformed the Internet
- De: Molly Knight Raskin
- Narrado por: Christine Marshall
- Duración: 6 h y 22 m
- Versión completa
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General4.5 out of 5 stars 65
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Narración:4.5 out of 5 stars 61
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Historia4.5 out of 5 stars 60
No Better Time tells of a young, driven mathematical genius who wrote a set of algorithms that would create a faster, better Internet. It's the story of a beautiful friendship between a loud, irreverent student and his soft-spoken MIT professor, of a husband and father who spent years struggling to make ends meet only to become a billionaire almost overnight with the success of Akamai Technologies, the Internet content delivery network he cofounded with his mentor.
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4 out of 5 stars
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An Overlooked Hero of 9-11
- De Jean en 05-27-16
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Big Science
- Ernest Lawrence and the Invention That Launched the Military-Industrial Complex
- De: Michael Hiltzik
- Narrado por: Bob Saouer
- Duración: 14 h y 48 m
- Versión completa
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General4.5 out of 5 stars 115
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Narración:4.5 out of 5 stars 100
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Historia4.5 out of 5 stars 99
Since the 1930s, the scale of scientific endeavors has grown exponentially. The birth of Big Science can be traced to Berkeley, California, nearly nine decades ago, when a resourceful young scientist pondered his new invention and declared, "I'm going to be famous!" Ernest Orlando Lawrence's cyclotron would revolutionize nuclear physics, but that was only the beginning of its impact.This is the incredible story of how one invention changed the world and of the man principally responsible for it all. Michael Hiltzik tells the riveting full story here for the first time.
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4 out of 5 stars
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An informative and thought-provoking book
- De Jean en 08-23-15
De: Michael Hiltzik
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The Chaos Imperative
- How Chance and Disruption Increase Innovation, Effectiveness, and Success
- De: Ori Brafman, Judah Pollack
- Narrado por: Drew Birdseye
- Duración: 4 h y 28 m
- Versión completa
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General4.5 out of 5 stars 63
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Narración:4.5 out of 5 stars 57
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Historia4.5 out of 5 stars 56
Ori Brafman and management consultant Judah Pollack dramatically demonstrate how even the best and most efficient organizations - from Fortune 500 companies to today's US Army - can become more innovative by allowing a little unstructured space and "contained chaos" into their planning and decision-making. Through their consulting work, they realized that while structure and hierarchy are essential both in large corporations and small groups, too much of either can stifle creativity.
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5 out of 5 stars
-
a must read!!
- De Kelly Pavich en 05-26-19
De: Ori Brafman, y otros
-
The Birth of the Pill
- How Four Crusaders Reinvented Sex and Launched a Revolution
- De: Jonathan Eig
- Narrado por: Gayle Hendrix
- Duración: 12 h y 26 m
- Versión completa
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General4.5 out of 5 stars 253
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Narración:4 out of 5 stars 227
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Historia4.5 out of 5 stars 226
We know it simply as "the pill", yet its genesis was anything but simple. Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic.
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5 out of 5 stars
-
Overall Excellent Read
- De Rachel en 04-02-22
De: Jonathan Eig
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Seeing What Others Don't
- The Remarkable Ways We Gain Insights
- De: Gary Klein
- Narrado por: Christopher Lane
- Duración: 9 h
- Versión completa
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General4.5 out of 5 stars 382
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Narración:4.5 out of 5 stars 338
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Historia4.5 out of 5 stars 336
Insights—like Darwin's understanding of the way evolution actually works, and Watson and Crick's breakthrough discoveries about the structure of DNA-can change the world. We also need insights into the everyday things that frustrate and confuse us so that we can more effectively solve problems and get things done. Yet we know very little about when, why, or how insights are formed—or what blocks them. In Seeing What Others Don't, renowned cognitive psychologist Gary Klein unravels the mystery.
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3 out of 5 stars
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Not enough actionable ideas
- De Blair en 02-24-15
De: Gary Klein
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For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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The Antidote
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In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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Shallow and lifeless
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Bottle of Lies
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Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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Jim Geraghty has been a passionate participant in the orphan drug revolution since its inception―a leader in the field as a strategy consultant, biotechnology executive, and venture entrepreneur. His book is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen. And it tells deeply personal stories of patients and parents willing to risk untried new therapies.
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powerful and insightful
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Moonshot
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A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made “the impossible possible”—creating, testing, and manufacturing a safe and effective COVID-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer overcame a series of crises that were compounded by social and political unrest.
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4 out of 5 stars
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Incredible, consuming, history.
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The Breakthrough
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Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
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eBoys
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The first inside account of life within a Silicon Valley venture capital firm, eBoys is the fascinating true story of the six tall men who backed eBay, Webvan, and other billion-dollar start-ups that are transforming the Internet and setting a new pace for the economy - an audible.com audio exclusive!
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Cable Cowboy
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John Malone, hailed as one of the great unsung heroes of our age by some and reviled by others as a ruthless robber baron, is revealed as a bit of both in Cable Cowboy. For more than 25 years, Malone has dominated the cable television industry, shaping the world of entertainment and communications, first with his cable company, TCI, and later with Liberty Media. Written with Malone's unprecedented cooperation, the engaging narrative brings this controversial capitalist and businessman to life.
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Potential to be a great story - let down
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The Demon Under The Microscope
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The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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5 out of 5 stars
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Great Book!!!!!
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The Drug Hunters
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- Duración: 7 h y 35 m
- Versión completa
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General4.5 out of 5 stars 1,174
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Narración:4.5 out of 5 stars 1,064
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Historia4.5 out of 5 stars 1,063
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
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3 out of 5 stars
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Aargh!
- De Curmud the prof en 05-20-17
De: Donald R. Kirsch PhD, y otros
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Regenesis
- How Synthetic Biology Will Reinvent Nature and Ourselves
- De: George M. Church, Ed Regis
- Narrado por: Peter Lerman
- Duración: 10 h y 47 m
- Versión completa
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General4.5 out of 5 stars 72
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Narración:4 out of 5 stars 59
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Historia4.5 out of 5 stars 59
In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies - far from the out-of-control nightmare depicted in science fiction - have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.
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5 out of 5 stars
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Brilliant! But please update!
- De Nick en 01-28-21
De: George M. Church, y otros
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An Elegant Defense
- The Extraordinary New Science of the Immune System: A Tale in Four Lives
- De: Matt Richtel
- Narrado por: Fred Sanders
- Duración: 12 h y 33 m
- Versión completa
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General4.5 out of 5 stars 706
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Narración:4.5 out of 5 stars 595
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Historia4.5 out of 5 stars 594
A magnificently reported and soulfully crafted exploration of the human immune system - the key to health and wellness, life and death. An epic, first-of-its-kind audiobook, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize-winning New York Times journalist.
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3 out of 5 stars
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Weak foundation, good conclusion
- De David en 03-24-19
De: Matt Richtel
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Pharma
- Greed, Lies, and the Poisoning of America
- De: Gerald Posner
- Narrado por: Jacques Roy
- Duración: 22 h y 55 m
- Versión completa
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General4.5 out of 5 stars 177
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Narración:5 out of 5 stars 150
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Historia4.5 out of 5 stars 148
Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.
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5 out of 5 stars
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Great book, but with some issues
- De Irina en 06-12-20
De: Gerald Posner
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The Gene
- An Intimate History
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 19 h y 22 m
- Versión completa
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General4.5 out of 5 stars 5,859
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Narración:4.5 out of 5 stars 5,144
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Historia4.5 out of 5 stars 5,097
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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5 out of 5 stars
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It's a Wonderful Book
- De JKC en 06-02-16
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Lessons from the Titans
- What Companies in the New Economy Can Learn from the Great Industrial Giants to Drive Sustainable Success
- De: Scott Davis, Carter Copeland, Rob Wertheimer
- Narrado por: Jim Denison
- Duración: 11 h y 14 m
- Versión completa
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General4.5 out of 5 stars 79
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Narración:4.5 out of 5 stars 62
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Historia4.5 out of 5 stars 62
Filled with illuminating case studies and brilliant in-depth analysis, this invaluable book provides a multitude of insights that will help you weather market upheavals, adapt to disruptions, and optimize your resources to your best advantage.
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5 out of 5 stars
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The best business book I’ve ever read!
- De Ken Fridley en 08-25-22
De: Scott Davis, y otros
Lo que los oyentes dicen sobre The Billion Dollar Molecule
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total4 out of 5 stars
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Ejecución1 out of 5 stars
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Historia4 out of 5 stars
- Anonymous User
- 05-05-23
Book is interesting but narrator is not
Nothing against the author but it was really hard for me to stay engaged with the narrator. I would find myself spacing out consistently which would detract from the story because of the performance. Because of this I returned the book
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