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From Breakthrough to Blockbuster
- The Business of Biotechnology
- Narrado por: Chris Andrew Ciulla
- Duración: 7 h y 1 m
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From Breakthrough to Blockbuster
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Resumen del Editor
Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources.
Biotech companies have met the challenge by creating nearly 40% more of the most important treatments for previously unmet medical needs. Moreover, they have done so with much lower overall costs.
From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them. It paints a portrait of the crucial roles played by academic research, venture capital, contract research organizations, the capital markets, and pharmaceutical companies, demonstrating how a supportive environment enabled the entrepreneurial biotech industry to create novel medicines with unprecedented efficiency. In doing so, it also offers insights for any industry seeking to innovate in uncertain and ambiguous conditions.
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Imagine running a business without a strategy. It would be akin to driving blindfolded, to building a house without a blueprint. The concept of strategy changed all that, paving the way for the creation of the modern corporate world. The Lords of Strategy provides listeners with a deeper understanding of the world they compete in, and a sharper eye for what works — and what doesn’t — when forging strategy.
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5 out of 5 stars
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Super Book of Narrow Interest
- De Roy en 08-23-10
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Attacker's Advantage
- Turning Uncertainty into Breakthrough Opportunities
- De: Ram Charan
- Narrado por: Mark Bramhall
- Duración: 6 h y 8 m
- Versión completa
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General4 out of 5 stars 80
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Narración:4 out of 5 stars 65
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Historia4 out of 5 stars 66
In The Attacker's Advantage, Charan reveals the upside of uncertainty for those leaders who are nimbly positioned to anticipate the catalysts of disruption and embrace change. He updates and adapts the principles of his previous best sellers to address the current turbulent business environment, cutting through the veil of complexity to concentrate on the new customer needs and expectations and providing the tools for corporate leaders to take their companies to a higher level.
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4 out of 5 stars
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Fantastic book - volume lower than usual
- De James Gajewski en 06-14-15
De: Ram Charan
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The Future of the Professions
- How Technology Will Transform the Work of Human Experts
- De: Richard Susskind, Daniel Susskind
- Narrado por: John Lee
- Duración: 12 h y 39 m
- Versión completa
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General4 out of 5 stars 272
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Narración:4 out of 5 stars 225
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Historia4 out of 5 stars 224
This book predicts the decline of today's professions and describes the people and systems that will replace them. In an Internet society, according to Richard Susskind and Daniel Susskind, we will neither need nor want doctors, teachers, accountants, architects, the clergy, consultants, lawyers, and many others to work as they did in the 20th century.
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3 out of 5 stars
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I Hope It's Not All True
- De John en 05-01-16
De: Richard Susskind, y otros
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Winning with Data
- Transform Your Culture, Empower Your People, and Shape the Future
- De: Tomasz Tunguz, Frank Bien
- Narrado por: James Patrick Cronin
- Duración: 5 h y 37 m
- Versión completa
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General4 out of 5 stars 90
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Narración:4.5 out of 5 stars 74
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Historia4 out of 5 stars 73
Winning with Data explores the cultural changes big data brings to business, and shows you how to adapt your organization to leverage data to maximum effect. Authors Tomasz Tunguz and Frank Bien draw on extensive background in big data, business intelligence, and business strategy to provide a blueprint for companies looking to move head-on into the data wave. Instrumentation is discussed in detail, but the core of the change is in the culture.
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1 out of 5 stars
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Content marketing
- De Adam Winn en 12-22-16
De: Tomasz Tunguz, y otros
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Out-Innovate
- How Global Entrepreneurs - from Delhi to Detroit - Are Rewriting the Rules of Silicon Valley
- De: Alexandre Lazarow
- Narrado por: Dennis Boutsikaris, Alexandre Lazarow
- Duración: 7 h y 42 m
- Versión completa
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General4.5 out of 5 stars 45
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Narración:5 out of 5 stars 33
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Historia4.5 out of 5 stars 34
As venture capitalist Alexandre Lazarow shows in this insightful and instructive book, this Silicon Valley "gospel" is due for a refresh - and it comes from what he calls the "frontier", the growing constellation of startup ecosystems, outside of the Valley and other major economic centers, that now stretches across the globe. The frontier is a truly different world where startups often must cope with political or economic instability and lack of infrastructure, and where there might be little or no access to angel investors, venture capitalists, or experienced employee pools.
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5 out of 5 stars
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Great material for SF and Frontier entrepreneurs!
- De Brett Fulmer en 04-15-20
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More Than You Know
- Finding Financial Wisdom in Unconventional Places
- De: Michael J. Mauboussin
- Narrado por: Sean Runnette
- Duración: 7 h y 27 m
- Versión completa
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General4.5 out of 5 stars 207
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Narración:4.5 out of 5 stars 178
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Historia4.5 out of 5 stars 176
Since its first publication, Michael J. Mauboussin's popular guide to wise investing has been translated into eight languages and has been named best business book by BusinessWeek and best economics book by Strategy+Business. Now updated to reflect current research and expanded to include new chapters on investment philosophy, psychology, and strategy and science as they pertain to money management.
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1 out of 5 stars
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Liked it better when it was written by Taleb
- De Ian en 11-24-18
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Lead and Disrupt
- How to Solve the Innovator's Dilemma
- De: Charles A. O'Reilly III, Michael L. Tushman
- Narrado por: James Foster
- Duración: 8 h y 36 m
- Versión completa
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General4.5 out of 5 stars 148
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Narración:4.5 out of 5 stars 121
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Historia4.5 out of 5 stars 116
In the past few years, a number of well-known firms have failed; think of Blockbuster, Kodak, or RadioShack. When we hear about their demise, it often seems inevitable - a natural part of "creative destruction." But closer examination reveals a disturbing truth: Companies large and small are shuttering more quickly than ever. What does it take to buck this trend? The simple answer is: ambidexterity. Firms must remain competitive in their core markets, while also winning in new domains.
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5 out of 5 stars
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Very very inspirational to me.
- De Fábio en 06-12-17
De: Charles A. O'Reilly III, y otros
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Born to Build
- How to Build a Thriving Startup, a Winning Team, New Customers and Your Best Life Imaginable
- De: Jim Clifton, Sangeeta Badal
- Narrado por: Braden Wright
- Duración: 3 h y 47 m
- Versión completa
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General4.5 out of 5 stars 77
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Narración:4.5 out of 5 stars 68
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Historia4 out of 5 stars 68
Written for anyone trying to figure out how to make the most of their lives, Born to Build seeks to inspire entrepreneurs and ambitious, self-motivated people to build something that will change the world. A builder’s venture could be a small business that grows into a mammoth enterprise, a thriving new division in an existing company, a nonprofit, a social enterprise, a church, a school - anything that creates economic growth and makes a lasting impact on society.
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5 out of 5 stars
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Powerful perspective shift
- De Diana_loves_audiobooks en 06-09-18
De: Jim Clifton, y otros
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Engine of Impact
- Essentials of Strategic Leadership in the Nonprofit Sector
- De: William F. Meehan III, Kim Starkey Jonker
- Narrado por: C. J. Lengua
- Duración: 7 h y 32 m
- Versión completa
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General4.5 out of 5 stars 45
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Narración:4.5 out of 5 stars 37
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Historia4 out of 5 stars 37
We are entering a new era - an era of impact. The largest intergenerational transfer of wealth in history will soon be underway, bringing with it the potential for huge increases in philanthropic funding. Engine of Impact shows how nonprofits can apply the principles of strategic leadership to attract greater financial support and leverage that funding to maximum effect.
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4 out of 5 stars
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Must listen for all nonprofit leaders
- De Peter A. Mello en 02-09-19
De: William F. Meehan III, y otros
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Machine, Platform, Crowd
- Harnessing Our Digital Future
- De: Erik Brynjolfsson, Andrew McAfee
- Narrado por: Jeff Cummings
- Duración: 10 h y 57 m
- Versión completa
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General4.5 out of 5 stars 1,195
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Narración:4.5 out of 5 stars 1,002
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Historia4.5 out of 5 stars 997
In The Second Machine Age, Andrew McAfee and Erik Brynjolfsson predicted some of the far-reaching effects of digital technologies on our lives and businesses. Now they’ve written a guide to help listeners make the most of our collective future. Machine | Platform | Crowd outlines the opportunities and challenges inherent in the science fiction technologies that have come to life in recent years, like self-driving cars and 3D printers, online platforms for renting outfits and scheduling workouts, or crowd-sourced medical research and financial instruments.
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5 out of 5 stars
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Both How AND Why for Techies
- De Dan Collins en 08-11-17
De: Erik Brynjolfsson, y otros
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Economics for the Common Good
- De: Jean Tirole, Steven Rendell - translator
- Narrado por: Jonathan Davis
- Duración: 18 h y 54 m
- Versión completa
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General4.5 out of 5 stars 55
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Narración:4.5 out of 5 stars 43
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Historia4.5 out of 5 stars 41
When Jean Tirole won the 2014 Nobel Prize in Economics, he suddenly found himself being stopped in the street by complete strangers and asked to comment on issues of the day, no matter how distant from his own areas of research. His transformation from academic economist to public intellectual prompted him to reflect further on the role economists and their discipline play in society. The result is Economics for the Common Good, a passionate manifesto for a world in which economics, far from being a "dismal science," is a positive force for the common good.
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4 out of 5 stars
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A Great Overview of the Challenges of Modern Econ
- De Zach Sullivan en 08-06-18
De: Jean Tirole, y otros
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Power and Prediction
- The Disruptive Economics of Artificial Intelligence
- De: Ajay Agrawal, Joshua Gans, Avi Goldfarb
- Narrado por: Tom Beyer
- Duración: 10 h y 7 m
- Versión completa
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General4.5 out of 5 stars 80
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Narración:4.5 out of 5 stars 71
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Historia4.5 out of 5 stars 71
In their bestselling first book, Prediction Machines, eminent economists Ajay Agrawal, Joshua Gans, and Avi Goldfarb explained the simple yet game-changing economics of AI. Now, in Power and Prediction, they go deeper, examining the most basic unit of analysis: the decision. The authors explain that the two key decision-making ingredients are prediction and judgment, and we perform both together in our minds, often without realizing it.
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5 out of 5 stars
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Inspire system thinking with informative examples
- De Lucy A. Pithecus en 11-16-22
De: Ajay Agrawal, y otros
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Competition Demystified
- A Radically Simplified Approach to Business Strategy
- De: Judd Kahn, Bruce C. Greenwald
- Narrado por: Timothy Andrés Pabon
- Duración: 14 h y 22 m
- Versión completa
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General4.5 out of 5 stars 49
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Narración:4.5 out of 5 stars 40
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Historia4.5 out of 5 stars 39
Bruce Greenwald, one of the nation's leading business professors, presents a new and simplified approach to strategy that cuts through much of the fog that has surrounded the subject. Based on his hugely popular course at Columbia Business School, Greenwald and his co-author, Judd Kahn, offer an easy-to-follow method for understanding the competitive structure of your industry and developing an appropriate strategy for your specific position.
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3 out of 5 stars
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Prof, we need the figures/graphs that’s in the the book
- De sid en 12-25-20
De: Judd Kahn, y otros
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Blind Spots
- Why We Fail to Do What’s Right and What to Do about It
- De: Max H. Bazerman, Ann E. Tenbrunsel
- Narrado por: Kate McQueen
- Duración: 7 h y 18 m
- Versión completa
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General4 out of 5 stars 98
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Narración:4 out of 5 stars 79
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Historia4 out of 5 stars 80
When confronted with an ethical dilemma, most of us like to think we would stand up for our principles. But we are not as ethical as we think we are. In Blind Spots, leading business ethicists Max Bazerman and Ann Tenbrunsel examine the ways we overestimate our ability to do what is right and how we act unethically without meaning to.
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4 out of 5 stars
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Great book
- De Ryan in SF en 11-15-18
De: Max H. Bazerman, y otros
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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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The Drug Discovery and Development Cycle
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The pharmaceutical drug discovery and development cycle is long and complex. This audiobook provides a concise overview of the whole process and offers insights into working in the pharmaceutical industry. It is ideal for individuals who are thinking about a career in this industry, as well as those who want to gain a general understanding of pharmaceutical drug discovery and development.
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Condensing the most important topics in all of clinical research in an easy-to-understand presentation. The 20 percent of what you need to know in order to be 80 percent proficient! The authors who have operated various levels of businesses in the clinical research industry since 2005 believe that more practical information pertaining to clinical research needs to be accessible to individuals who are new to the industry or are curious about entering the rewarding world of clinical trials.
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Jim Geraghty has been a passionate participant in the orphan drug revolution since its inception―a leader in the field as a strategy consultant, biotechnology executive, and venture entrepreneur. His book is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen. And it tells deeply personal stories of patients and parents willing to risk untried new therapies.
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4 out of 5 stars
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.
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Steve Taylor for the win
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The AI Revolution in Medicine
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General4.5 out of 5 stars 26
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Narración:4.5 out of 5 stars 22
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Historia4.5 out of 5 stars 22
Just months ago, millions of people were stunned by ChatGPT's amazing abilities–and its bizarre hallucinations. But that was 2022. GPT-4 is now here, with smarter, more accurate, and deeper technical knowledge. GPT-4 and its competitors and followers are on the verge of transforming medicine. But with lives on the line, you need to understand these technologies–stat.
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2 out of 5 stars
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Self-Serving Junk
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The Antidote
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Narración:4 out of 5 stars 64
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Historia4 out of 5 stars 65
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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For me this was not interesting
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Deep Medicine
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Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.
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5 out of 5 stars
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a must book for all doctors and patients.
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The Great American Drug Deal
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Narración:4.5 out of 5 stars 24
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Developing life-changing drugs is risky and expensive, but that’s not what makes them unaffordable. Drug pricing is a staple of every news cycle and political debate. And while we’ve struggled for decades to agree on solutions that serve all patients without jeopardizing the invention of new medicines, many Americans suffer because they can’t afford the drugs they need. Do we really have to choose between affordability and innovation?
De: Peter Kolchinsky
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The Founder's Dilemmas
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Often downplayed in the excitement of starting up a new business venture is one of the most important decisions entrepreneurs will face: should they go it alone, or bring in cofounders, hires, and investors to help build the business? More than just financial rewards are at stake. Friendships and relationships can suffer. Bad decisions at the inception of a promising venture lay the foundations for its eventual ruin.
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2 out of 5 stars
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Too much talk on the data
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The Song of the Cell
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From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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5 out of 5 stars
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Beyond Words Wonderful
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Bottle of Lies
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- De: Katherine Eban
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Narración:4.5 out of 5 stars 924
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From an award-winning Fortune reporter, an explosive narrative investigation of the generic drug boom that reveals the life-threatening dangers posed by globalization - The Jungle for pharmaceuticals.
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1 out of 5 stars
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overbearing self-righteous indignation
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Fundamentals of Clinical Trials
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General5 out of 5 stars 5
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Narración:5 out of 5 stars 4
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Historia5 out of 5 stars 4
This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.
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5 out of 5 stars
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A great overview in just 4 hours!
- De M. Buzard en 04-30-23
De: Lawrence M. Friedman, y otros
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The Breakthrough
- Immunotherapy and the Race to Cure Cancer
- De: Charles Graeber
- Narrado por: Will Collyer, Charles Graeber
- Duración: 7 h y 7 m
- Versión completa
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General4.5 out of 5 stars 512
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Narración:4.5 out of 5 stars 456
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Historia4.5 out of 5 stars 454
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
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5 out of 5 stars
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Surprisingly gripping
- De Kari Niles en 01-21-19
De: Charles Graeber
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- De: Thomas Hager
- Narrado por: Angelo Di Loreto
- Duración: 8 h y 39 m
- Versión completa
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General4.5 out of 5 stars 4,851
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Narración:4.5 out of 5 stars 4,199
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Historia4.5 out of 5 stars 4,181
Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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4 out of 5 stars
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
De: Thomas Hager
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The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- De: Walter Isaacson
- Narrado por: Kathe Mazur, Walter Isaacson
- Duración: 16 h y 4 m
- Versión completa
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General4.5 out of 5 stars 6,190
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Narración:4.5 out of 5 stars 5,250
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Historia4.5 out of 5 stars 5,217
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
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4 out of 5 stars
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Except for the author, this book is good!
- De Johan en 03-14-21
De: Walter Isaacson
Lo que los oyentes dicen sobre From Breakthrough to Blockbuster
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total5 out of 5 stars
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Ejecución5 out of 5 stars
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Historia5 out of 5 stars
- Momo Abbasi
- 04-28-24
Wonderful book!
If you want to understand the biotech industry you MUST READ this! Comprehensive and easy to follow.
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Total5 out of 5 stars
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Ejecución5 out of 5 stars
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Historia5 out of 5 stars
- Fox2
- 11-12-22
Excellent description of the biotech industry
Fantastic book describing the biotech industry from its beginning to now. Engaging and recommended to read or listen.
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Total2 out of 5 stars
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Ejecución3 out of 5 stars
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Historia2 out of 5 stars
- Anonymous User
- 09-12-23
Nothing to learn for pharma professionals
Nice introduction to the world of pharma R&D, but those who’ve been in the business have probably heard the stories many times already.
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