Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t already optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.

𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊𝐒

Transcript

YouTube

Apple Podcasts

Spotify

𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒

* Hudson River Trading uses deep learning to tackle one of the world's most complex systems: global capital allocation. They have a massive in-house GPU cluster, and they’re constantly adding new racks of B200s to ensure their researchers are never constrained by compute. Explore opportunities at hudsonrivertrading.com/dwarkesh\

* Google’s Gemini CLI turns ideas into working applications FAST, no coding required. It built a complete podcast post-production tool in 10 minutes, including fully functional backend logic, and the entire build used less than 10% of Gemini’s session context. Check it out on Github now!

* To sponsor a future episode, visit dwarkesh.com/advertise.

𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒

(00:00:00) – Three reasons evolution didn’t optimize for longevity

(00:12:07) – Why didn't humans evolve their own antibiotics?

(00:25:26) – De-aging cells via epigenetic reprogramming

(00:44:43) – Viral vectors and other delivery mechanisms

(01:06:22) – Synthetic transcription factors

(01:09:31) – Can virtual cells break Eroom’s Law?

(01:31:32) – Economic models for pharma

How will we feed the 100s of GWs of extra energy demand that AI will create over the next decade? On this episode, Casey Handmer (Caltech PhD, former NASA JPL, founder & CEO of Terraform Industries) walks me through how we can pull it off, and why he thinks a major part of this energy singularity will be powered by solar. His views are contrarian, but he came armed to defend them.

EPISODE LINKS

Transcript

YouTube

Apple Podcasts

Spotify

SPONSORS

- Lighthouse helps frontier technology companies like Cursor and Physical Intelligence navigate the U.S. immigration system and hire top talent from around the world. Lighthouse handles everything for you, maximizing the probability of visa approval while minimizing the work you have to do. Learn more at lighthousehq.com/employers

- To sponsor a future episode, visit dwarkesh.com/advertise.

TIMESTAMPS

(00:00:00) – Why doesn’t China win by default?

(00:08:28) – Why hyperscalers choose natural gas over solar

(00:18:01) – Solar's astonishing learning rates

(00:27:02) – How to build 50,000 acre solar-powered data centers

(00:40:24) – Environmental regulations blocking clean energy

(00:44:04) – Batteries replacing the grid

(00:49:14) – GDP is broken, AGI's true value must be measured in total energy use

(00:58:45) – Silicon wafers in space with one mind each

A deep dive with Lewis Bollard, who leads Open Philanthropy’s strategy for Farm Animal Welfare, on the surprising economics of the meat industry.

Why is factory farming so efficient? How can we make the lives of the 23+ billion animals living on factory farms more bearable? How far off are the moonshots (e.g., brainless chickens, cultivated meats, etc.) to end this mass suffering? And why does the meat industry have such a surprising amount of political influence?

For decades, innovation in the meat industry has actually made the conditions for animals worse. Can the next few decades of tech reverse this pattern?

Watch on YouTube; listen on Apple Podcasts or Spotify.

Donation match fundraiser

The welfare of animals on factory farms is so systemically neglected that just $1 can help avert 10 years of animal suffering.

After learning more about the outsized opportunities to help, I decided to give $250,000 as a donation match to farmkind.giving/dwarkesh. FarmKind directs your contributions to the most effective charities in this area.

Please consider contributing, even if it’s a small amount. Together, we can double each other's impact and give a total of $500,000.

Bluntly, there are some listeners who are in a position to give much more. Given how neglected this topic is, one such person could singlehandedly change the game for 10s of billions of animals. If you’re considering donating $50k or more, please reach out directly to Lewis and his team by emailing andres@openphilanthropy.org.

Timestamps

(00:00:00) – The astonishing efficiency of factory farming

(00:07:18) – It was a mistake making this about diet

(00:09:54) – Tech that’s sparing 100s of millions of animals/year

(00:16:16) – Brainless chickens and higher welfare breeds

(00:28:21) – $1 can prevent 10 years of animal suffering

(00:37:26) – Situation in China and the developing world

(00:41:41) – How the meat lobby got a lock on Congress

(00:53:23) – Business structure of the meat industry

(00:57:42) – Corporate campaigns are underrated