• 103. Neuroimaging with Prof Mitul Mehta
    May 8 2024
    Professor Mitul Mehta explains how his studies in neuroscience and the role of dopamine in learning and memory led to his own career in neuroimaging. He offers an overview of what neuroimaging entails and how these scans can contribute to the advancement of research. Drawing from his latest research centred around Schizophrenia, Mitul delves into our understanding of drug interactions within the brain and how these can be used in drug development.DopamineDopaminergic systemExecutive functionEpisodic memoryBrain imagingLesion StudyPet scannerTemporal resolutionFmriMRIReceptorsneuronsBlood Brain BarrierKetamineCocainePsilocybinSchizophrenia
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    1 hr and 2 mins
  • 102. MDMA and the Octopus with Dr Gül Dölen
    Apr 24 2024

    In this episode, Prof Neill and Dr Thurgur meet with Dr Gül Dölen, a neuroscientist known for studying social behaviour and psychedelic drugs. Together, they explore the role of critical periods in trauma and mental health; following the potential of Psychedelics in reopening critical periods which were previously thought to be closed, they debate whether a critical period closing is ever truly permanent.

    Critical period

    Sensitive period

    Lorenz 1935

    MDMA

    cocaine

    Oxytocin

    Ibogaine

    psilocybin

    Theory of mind

    Albert Hofmann

    Schizophrenia

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    1 hr and 7 mins
  • 101. LSD, Nazis and the CIA with Norman Ohler
    Apr 10 2024

    In this episode, Prof Nutt meets with German author Norman Ohler as he speaks about his new book “Tripped” which addresses drug use in post-Nazi Germany. Ohler shares how a secret history held back therapeutic research of psychedelic drugs for decades and eventually Nazi policies became part of the foundation of America’s War on Drugs. Ohler discusses theories as to why substances have been omitted from certain parts of history. This episode delves into deep debates regarding the weaponisation of substances within war environments, touching upon the CIA’s attempts to weaponise psychedelics such as LSD in their MK Ultra experiments.


    Methamphetamine

    Amphetamine

    Blitzkrieg

    Blitzed – drugs in nazi Germany book

    LSD

    Tripped

    Cocaine

    Albert Hofmann

    Psychedelics David Nutt

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    54 mins
  • 100. 100 Years of the Maudsley Hospital with Dr James Rucker
    Mar 27 2024

    On the 100th Episode of the Drug Science podcast, Prof David Nutt meets with Dr James Rucker to celebrate the 100th anniversary of Maudsley Hospital. James shares his experiences as one of the first clinicians in a psychedelic study hosted by David Nutt before explaining his own personal journey into psychedelic research.

    Starting from a PhD in Genetics, James’ interest shifted, becoming increasingly interested in psychiatry and discusses his research into psilocybin regarding both its optimum dosage as well as its effectiveness in treatment resistant depression.


    Depression

    Maudsley Hospital

    Maudsley Hospital Psychedelic Research

    NIHR

    Compass pathways

    Psilocybin

    Magic medicine documentary

    Mdma

    Dmt

    Ketamine

    MAPS

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    42 mins
  • 99. Anyone's Child with Anne-Marie Cockburn and Jane Slater
    Mar 13 2024


    In this episode, we meet with Jane Slater, co-founder of Anyone’s Child and Anne Marie, a mother who tragically lost her child, Martha, to an accidental overdose. Anne and Jane discuss the consequences of drug policy failures and the need for safe drug use education, drawing in on Anne’s personal journey. She discusses the pain of losing a loved one to a preventable drug related death and how this pain led to the start of Anyone's Child - creating a voice for those who have been directly impacted by drug policy failures and are now calling for the legal control and regulation of the drug market.

    Anyone's child

    Transform drugs

    Anyone's Child Get involved

    Release Harm Reduction Advice

    Drug information


    Ecstasy

    Heroin


    Overdose prevention centres

    The loop


    How to regulate psychedelics book


    Good Morning Britain

    Dealing with grief


    UNGAS 2016

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    58 mins
  • 98. The Merseyside Experiment with John Marks
    Feb 28 2024

    In this week's episode, we feature John Marks, an Addiction Psychologist who spearheaded the Merseyside experiment in northwest England from 1982 to 1995. Throughout this 13-year period, Marks fearlessly operated clinics in Liverpool, basing his practice on the long-term maintenance prescribing of opiates to opiate users.

    The high media profile of his work, set against the backdrop of febrile local politics in Liverpool, brought immense political pressure. This pressure eventually led to the closure of the clinics.


    Tune in to this episode as John Marks shares his first-hand experiences, recounting the challenges, triumphs, and controversies surrounding his work on the experiment. He provides insights into the intricacies of the UK's drug laws and discusses their impact on his experiment.

    Alcohol

    heroin

    Misuse of drugs act 1971

    The ‘Classic paper’ – The North Wind and the Sun

    Accidy, Addiction and the Prohibition

    Electroencephalographic Correlates of Psychometry

    EEG and Psychometry

    The Cartesian Bridge: On the Psychology of Consciousness and the Psychopathology of Addiction and Schizophrenia

    North wind and the sun

    County lines

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    29 mins
  • 97. 5-MeO-DMT with Patrick Cox
    Feb 14 2024

    In this episode, we meet with Patrick Cox, a fashion designer with a background collaborating with Vivienne Westwood. Patrick shares his personal journey from his lifestyle in fashion, led to confronting deep-seated intergenerational trauma. Patrick opens up about undertaking the highly secretive Hoffman Process, and the transformative impact this had on him. From there, he further recounts his journey through the healing use of psychedelics, emphasising the transformative power of ego death. Patrick highlights how this journey led to him becoming a 5-MeO facilitator, and guiding others through these healing experiences.

    5-MEO

    Vivienne Westwood

    The Hoffman process

    Christopher Hitchens

    LSD

    Cannabis

    Ayahuasca

    Ego Death

    Hermet phase

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    1 hr and 5 mins
  • 96. Ayahuasca: Before and After with Evgeny Lebedev
    Jan 31 2024

    In this episode, David Nutt meets with Evgeny Lebedev, owner of the Independent and Evening Standard newspaper. Lebedev shares his transformative journey during his first Ayahuasca ceremony in Costa Rica. Throughout the episode, Lebedev not only shares insight into the ceremony's practices but also describes each personal ayahuasca experience and the themes that tied them together. He highlights his revelations resulting from the ceremony and they discuss the potential of psychedelics within healing practices.

    Ayahuasca

    Psilocybin

    LSD

    DMT

    Small Pharma

    Medical Cannabis

    Vietnam hippies

    OCD

    Depression

    Dr Gabor Mate

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    47 mins