You’ve heard the saying, “it’s the little things that make a difference,” right? In this episode of Spinal Cast you’ll discover just how profound those little things can be! Dr. Samuel Chung (Sam) and Noa Grooms hail from Northeastern University where they have been working with C. elegans (roundworms). They uncovered a fascinating phenomenon: by precisely cutting a fiber in a neuron they can observe regrowth and redevelopment and begin to understand how they can influence it. It is this seemingly small breakthrough that holds the potential to transform the way we approach spinal cord injury therapies.

With Dr. Chung’s expertise in lasers, optics and bioengineering, combined with Noa’s deep understanding of genetics, they are driving a revolution in neuroscience that gives testament to the power of interdisciplinary collaboration.

We also discuss the vital role of MCPF funding and the “New Investigator Grant.” By supporting new investigators in the field, MCPF is making strategic investments in high-risk, high-reward projects and championing visionary thinkers. The extraordinary achievements of Sam and Noa underscore the immense value of this approach.

What might seem like a ripple now is destined to create waves that will change lives for those living with spinal cord injuries. Tune in!

Bios for Sam and Noa can be found below.

Thanks again to Sam and Noa for being our guests on today's podcast! This production is a collaborative effort of volunteers working to create a quality audio and visual experience around the subject of spinal cord injury. A special shout out of appreciation to Clientek for providing studio space and top-notch recording equipment. Most importantly, thank YOU for being part of the Spinal Cast audience!

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Samuel Chung, Ph.D.

Prof. Chung is an Assistant Professor in the Bioengineering Department at Northeastern University. He leads a multidisciplinary group to study a special form of regeneration that can regrow the mammalian central nervous system. His laboratory leverages highly precise laser surgery and powerful genetic tools in the simple roundworm C. elegans to illuminate the biological mechanisms of regeneration. His laboratory also develops optical tools to clearly see individual brain cells and their regrowth, with the goal of automating his experiments. Together, his technologies and his unique model in the worm enable him to make broad, fundamental discoveries that may ultimately produce a viable therapy for spinal cord injuries.

Noa Grooms

Noa Grooms is a recently graduated bioengineering PhD student from Samuel Chung's laboratory at Northeastern University. His research explores the genetic mechanisms underlying brain cell regeneration. In his studies, Noa identified cAMP response element binding protein (CREB) as a primary driver of protein expression that promotes regeneration across several neurons in the roundworm C. elegans. His results also demonstrate a strong cell-type dependence on regenerative capacity and contributions from different genes.