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On the eve of what was supposed to be a triumphant "Cancerversary" with her husband Jack to celebrate three years of being cancer-free, Daisy suffers a devastating blow: Her doctor tells her that the cancer is back, but this time it's an aggressive stage four diagnosis. She may have as few as four months left to live. Death is a frightening prospect - but not because she's afraid for herself.

Mia Graydon's life looks picket-fence perfect; she has the house, her loving husband, and dreams of starting a family. But she has other dreams too - unexplained, recurring ones starring the same man. Still, she doesn’t think much of it, until a relocation to small-town Pennsylvania brings her face to face with the stranger she has been dreaming about for years. And this man harbors a jaw-dropping secret of his own - he's been dreaming of her too. Determined to understand, Mia and this not-so-stranger search for answers.

Jubilee Jenkins has a rare condition: She's allergic to human touch. After a nearly fatal accident, she became reclusive, living in the confines of her home for nine years. But after her mother dies, Jubilee is forced to face the world - and the people in it - that she's been hiding from. Jubilee finds safe haven at her local library, where she gets a job. It's there she meets Eric Keegan, a divorced man who recently moved to town with his brilliant, troubled adopted son. Eric is struggling to figure out how to be the dad - and man - he wants so desperately to be.

Tessa Russo is the mother of two young children and the wife of a renowned pediatric surgeon. Despite her own mother's warnings, Tessa has recently given up her career to focus on her family and the pursuit of domestic happiness. From the outside, she seems destined to live a charmed life. Valerie Anderson is an attorney and single mother to six-year-old Charlie - a boy who has never known his father.

Alice Howland is proud of the life she worked so hard to build. At 50 years old, she's a cognitive psychology professor at Harvard and a world-renowned expert in linguistics with a successful husband and three grown children. When she begins to grow disoriented and forgetful, a tragic diagnosis changes her life - and her relationship with her family and the world - forever.