The Immortal Life of Henrietta Lacks

De: Rebecca Skloot

Narrado por: Cassandra Campbell, Bahni Turpin

Number one New York Times best seller.

Now a major motion picture from HBO® starring Oprah Winfrey and Rose Byrne.

One of the “most influential” (CNN), “defining” (Lit Hub), and “best” (The Philadelphia Inquirer) books of the decade.

One of essence’s 50 most impactful Black books of the past 50 years.

Named one of the best books of the year by The New York Times Book Review, Entertainment Weekly, O: The Oprah Magazine, NPR, Financial Times, New York, Independent (UK), Times (UK), Publishers Weekly, Library Journal, Kirkus Reviews, Booklist, Globe, and Mail.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.

Henrietta’s family did not learn of her “immortality” until more than 20 years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family - past and present - is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.

Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family - especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

©2010 Rebecca Skloot (P)2010 Random House

Reseñas de la Crítica

Winner of The Chicago Tribune Heartland Prize for nonfiction

"The story of modern medicine and bioethics - and, indeed, race relations - is refracted beautifully, and movingly.” (Entertainment Weekly)

"Writing with a novelist's artistry, a biologist's expertise, and the zeal of an investigative reporter, Skloot tells a truly astonishing story of racism and poverty, science and conscience, spirituality and family driven by a galvanizing inquiry into the sanctity of the body and the very nature of the life force." (

Booklist)

The Secret Life of an American Cancer Cell

About a month ago, I donated blood at the American Red Cross. I'm there about every other month - or exactly at 56 days, depending on how persistent those cheerful calls, with their underlying tone of urgency, are. Last time I was there, there was an addition to the binder of forms I needed to review: a disclosure that my blood could be used for research, and if I didn't agree to that, I shouldn't donate.

I was puzzled: why the consent now, since Rebecca Skloot's "The Immortal Life of Henrietta Lacks" had been published in 2010? I hadn't read the book, but I had followed the debate about informed consent. I didn't really think about how the Lacks family felt about Henrietta's cells (called HeLa) living in labs twice as long as Henrietta herself did. I sure didn't think about HeLa economics.

On June 13, 2013, the US Supreme Court ruled that naturally occurring genes cannot be patented in Association for Molecular Pathology v. Myriad Genetics, Docket 12-398. On August 7, 2013, the National Institutes of Health announced that they had reached an agreement with Henrietta's descendants to use HeLa cells with the informed consent of a board, including two of her family members.

I heard an interview with Skloot shortly after on NPR, and decided it was time to read/listen to "The Immortal Life." I was astounded by the sheer tenacity of HeLa cells (cancer cells from an especially aggressive form of cervical cancer caused by one of the HPV viruses, strengthened by untreated neuro-syphillis) and by the research and discoveries based on those cells. HeLa was instrumental in the development of the polio vaccine, tests to identify cancer, studies on chemical toxicity . . . and so much more. When I checked PubMed as I wrote this review, there were 76,057 peer reviewed articles with HeLa mentioned in the abstracts.

Skloot's careful research, wonderfully descriptive writing, and absolute respect for the Lacks family was evident. Skloot described the family and some of its very memorable members, especially Henrietta's daughter, Deborah, who really wanted to know the HeLa story - but was also afraid to find out everything, for good reason. Skloot avoids a sociological analysis of the Lacks family, which is good - that would have made them a 'study', not real people. There was an overarching irony: despite the invaluable contribution Henrietta made to medicine, most of her surviving family did not have medical insurance.

Skloot was careful to use the actual dialect and pronunciations of the people she interviewed in the Audible book. I don't know how it looked in writing, but it made a good listen. The narrators, Cassandra Campbell and Bahni Turpin, worked well together.

I'll still donate blood, of course - but from now, my imagination of what my cells are doing won't be limited to surgeries involving people who have the same blood type.

This Audible book doesn't come with a downloadable reference guide, but there are pictures of the Lacks family and a lot of the scientists mentioned in the book available on Google Books.

[If this review helped, please let me know by pushing Helpful. Thanks!]

Many stories in one

The Immortal Life of Henrietta Lacks, like many compelling works of nonfiction, was written to tell one story, but, in its creation, uncovered several others. On the surface, Rebecca Skloot's book is about a line of cells, extracted from a single cancer patient in the 1950s, that went on to be the most widely studied human cell line in the world. On another level, it's about an evolving debate over the medical ethics of cell and DNA ownership. How much say should patients have in the use of their own genetic material? How does society balance the needs of medical research against concerns for privacy and individual autonomy?

On still another level, The Immortal Life of Henrietta Lacks is about race relations in America, about uneven levels of white privilege and black privilege when it comes to access to information and advocacy. It's a story about casual exploitation by a scientific establishment that was trained to compartmentalize and not think of its work in personal terms. Finally, it's a story of a family struggling to find emotional and spiritual closure after the years following the death of their mother, who continues in a strange and somewhat mystifying afterlife.

If the book had simply been about science and ethical questions pertaining to the cells of Henrietta Lacks, I might not have found it more than mildly interesting, but the human element gives the story many more dimensions. I think Skloot did an excellent and honest job of conveying how one poor, black family from the rural South perceives science and medicine. Of course, they understand and care about the basic things that most Americans do, but their views are colored by a history and identity that, I, a well-educated, middle-class white northerner, simply haven't lived in. It was a fascinating and ultimately hopeful exploration beyond stereotypes and into how human beings really relate to questions that can never be entirely viewed in clinical, medical terms. You get to know Henrietta's extended family, and to view her life and unintended contribution to science as they do.

Overall, the book felt like an extended episode of This American Life, in that it didn’t explore (or resolve) any issue in great depth, but was engagingly put together and taught me a little about a lot of different subjects. Since it’s not a long read, I’d say it’s well-deserving of its awards and your time.

Can you sell your cells?

This is a necessary book - aside from informing us about what seems today like the the dark ages of cancer research and the reported unfair treatment of minorities by the medical community in the era of Henrietta Lacks, it's time we all became more enlightened as to the fate of our body products once we part with them in a doctor's office, lab or hospital. This book raises important issues as to the space required for storage of all discarded tissue, which is unlike printed material that can be converted to digital format.

As an historical novel there are bound to be characters that are not "likable" nor relatable in the usual fictional sense. This family was troubled in many ways, in addition to the implied racial implications, the possible malpractice issues regarding the HeLa cells, and losing any financial stake in the success of the HeLa cell line. The family came to Baltimore to be part of the then growing steel industry. They were originally from a bare bones town in Virginia, having farmed their own tobacco crops after indirectly inheriting the property after being emancipated from slave status. There were some hard workers amongst the marginal characters, but basically this was a hard-strapping family who had to make do in order to survive. And several of them fell by the wayside to crime and mental dysfunction.

The book is well-written, even with the frequent disjunctions in time periods. It can be difficult to follow the genealogy and plethora of major and minor characters, and the myriad mentions of various studies. But all that is mere technicality.

The book accomplishes its goal of promoting proper documentation of, and credit for - financial or otherwise - biological tissues that are saved and used for research. It raise the question of ownership of our own tissues, and whether or not we have proprietary rights to our own bodies, in situ or in vitro.

What are your legal rights to your body?

This is a well-written non-fiction book, that provides back ground information about unfair treatment of minorities by medical research. Cassandra Campbell and Bahni Turpin did great job with the narration of the book. The story of Henrietta Lacks and her family is interesting and the discovery and care of the Hi La cells. One major item about the family is the lack of education played a major role in their understanding and ability to control the situation. The book accomplishes its goal of promoting proper documentation of biological tissue research. It raises the question of ownership of our own tissues and whether or not we have proprietary rights to our bodies in situ or in vitro. This question needs to be answered NOW not in the future. The other teaching of the book was how important education is to each individual. This is an absolute must read book for everyone on this planet.

Part science, part family drama and all good

Great story about how science and families can both be disfunctional. This one explains that sometimes things done in the name of science to advance the health of people can completely set aside the humanity of what they are doing. And that children, our most precious commodity, truly need love, care, and acknowledgment that they are important. This story explains and advocates both. Really well done.

A must read

This extraordinary story couldn't have held my attention more if it were fiction. The fact that it is true makes it amazing. It is a cautionary tale that is educational, inspiring, and thought provoking. The introduction and final interview with the author rounds it out. I've already started to re-read it and will recommended to my friends, especially those in book clubs. The performances by Cassandra Campbell and Bahni Turpin truly brought the "characters" to life. The emotions they express are raw and evoke deep compassion. This is one of those books that is better as a result of listening to it.

Rebecca Skloot's attempt to get researchers to think about the person behind the samples they work on is an important one. We don't like to be thought of as nothing but a number, much less a cell. When I first learned that genes could be patented and that research into the condition covered by that patent could be controlled as a result, it sounded like blackmail and I was shocked. That was nothing compared to the shock upon learning about HeLa through this story.Anyone involved in clinical trials should be thankful that steps have been taken to prevent a repetition of Henrietta's story.

Skloot makes it clear, however, that research into the many chronic and fatal conditions facing us is dependent on tissue donation and use. The manner in which they're obtained and used is what makes for ethical, not just medical, considerations.

Well done and Entertaining

I read this book after hearing a review of the book on NPR and a discussion of the HeLa cells. The layout of the book is wonderful - a mixture of some chronological details and some memories, presented in a narrative - that keeps you entertained and interested, without being confusing or slow. The subject demands many scientific details be included, and the author presents these details clearly and in an easily-understood way which ensures that this book will be enjoyed by all. The changes in medical confidentiality since 1951 are dramatic and the book presents both sides of the issue fairly and objectively, allowing readers to form their own opinions.

A Must Hear, especially if you are in Medicine.

What did you love best about The Immortal Life of Henrietta Lacks?

A captivating, and at times, jarring story that melds the human dimension with evolving ethical issues of tissue collection and use over the past 60 years. Wonderfully narrated.

What did you like best about this story?

The human side of the Lacks family's struggles - societal, financial, medical and especially their conflict with evolving ethical standards of the medical establishment.

Which character – as performed by Cassandra Campbell and Bahni Turpin – was your favorite?

Deborah

If you were to make a film of this book, what would be the tag line be?

Henrietta's immortality

HeLa was a person

Would you recommend this audiobook to a friend? If so, why?

What a frustrating story to try to gather. Thank you for your work. Thank you Deborah for your sharing witht eh author. Your struggle alone was almost defeating to me.

A fabulous read

Non-fiction doesn't get much better than this. Its' so well written and very well read too. Go for it!