How did the USA build one of the world's most comprehensive cystic fibrosis care systems? In Part 1 of our deep dive, Peter Mogayzel explores the development of national cystic fibrosis centres, the impact of newborn screening, and how a strong foundation in care standards transformed outcomes across generations.

Timestamps:

00:00 – Introduction

01:38 – Care models

02:40 – Early screening

04:20 – CF Foundation

05:33 – What's changed?

In this quickfire introduction, Peter J. Mogayzel answers fast questions about the evolution of cystic fibrosis care in the USA, from early screening and survival milestones to innovation, policy, and equitable access. A perfect primer on where cystic fibrosis care stands today.

In the second episode of this three-part series, we delve into the science behind Refractory Chronic Cough (RCC), focusing on the role of neuronal hypersensitivity and how the cough reflex becomes dysregulated.1 Join leading experts as they explain the neurobiology of RCC, discuss the latest research, and share practical insights for identifying RCC in clinical practice.

Could 'gravity prescriptions' become a new form of therapy? Spiegel explores the concept of bio-gravitational medicine, from flotation tanks to National Aeronautics and Space Administration (NASA)-developed rehabilitation technology, and how virtual reality may help patients simulate weightlessness. He also predicts what the next decade of gravity research will bring.
Timestamps:
01:20 – Bio-gravitational medicine explained
04:15 – Gravi-type
09:08 – Anti gravity devices
11:09 – Virtual reality

How does gravity shape our internal ecosystems? Spiegel explains the emerging science linking the microbiome, serotonin, and balance. He discusses how microgravity alters gut health in astronauts and why posture could affect digestion and mood on Earth.
Timestamps:
00:59 – Microbiome and balance
03:36 – Microgravity gut effects
06:25 – Serotonin and gravity link
09:10 – Tools for studying gut-gravity

In this first deep dive, Spiegel unpacks his bold hypothesis: that irritable bowel syndrome and similar disorders could stem from gravity intolerance. He discusses his self-experiment simulating stronger gravity, the role of core strength in symptom relief, and how altitude affects gastrointestinal conditions.

Timestamps:
01:04 – What is gravity intolerance?

02:55 – Gravity and chronic conditions

06:18 – Gravity and irritable bowel syndrome

09:29 – Self experiment

12:37 – Gravity's effect on pregnancy

16:43 – How should patients and clinicians think about gravity?

Brennan Spiegel answers rapid-fire questions about the effects of gravity on the human body and mind. From fatigue to irritable bowel syndrome to mental health, learn why gravity might be one of medicine's most overlooked forces, and how virtual reality is helping researchers study its effects.

In this final episode, Ghatak and Olivo reflect on leadership, mentorship, and the legacy of innovation in diagnostics. Discover what drives them to keep pushing the boundaries of healthcare technology.

Timestamps:

00:00 - Introduction

00:45 - Good leadership

05:04 - Advice for young professionals

07:34 - Diagnostic gaps

09:34 - Maintaining motivation

10:33 - ImmunoProfile legacy