Episodios

  • Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 2

    Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 2
    Jul 24 2025

    In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

    Timestamps:

    1:20 - Current barriers to timely diagnosis

    4:35 - How close are we to identifying all patients with Alpha 1?

    5:20 - Role of consumer genomics in alpha detection

    6:20 – Targeted testing amongst COPD patients
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    8 m
  • Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 3

    Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 3
    Jul 24 2025

    In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

    Timestamps:

    01:00 - Management of Alpha 1

    03:30 - Augmentation therapy

    05:50 - The discussion of neonatal screening for Alpha 1

    08:00 - Evolving landscape

    09:40 - Patients’ challenges with Alpha 1

    11:20 - Closing comments on Alpha 1
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    13 m
  • Hema Now: Episode 22: The State of Sickle Cell

    Hema Now: Episode 22: The State of Sickle Cell
    Jul 23 2025
    In this episode, host Jonathan Sackier is joined by Steven Okoli, Honorary Senior Clinical Lecturer at Imperial College London. From leading the UK’s first adult stem cell transplant trial for sickle cell disease to driving innovation in AI-guided transfusion strategies, Okoli shares how clinical research, patient advocacy, and equity-driven care are reshaping the landscape of haemoglobinopathies in the UK and beyond. Timestamps 00:00: Introduction 01:58: Quickfire round 09:09: Pioneering adult stem cell transplant in sickle cell 11:41: Combining AI and genetics for blood transfusion 13:58: Systemic disparities in sickle cell 20:58: Education and advocacy 23:30: Non-cancerous blood disorders 25:18: What’s next in sickle cell? 27:27: Okoli’s three wishes for healthcare
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    32 m
  • Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Quickfire

    Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Quickfire
    Jul 22 2025

    In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.
    Más Menos
    4 m
  • Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 1

    Unpacking Rare Lung Diseases: Alpha-1 Antitrypsin Deficiency: Deep Dive 1
    Jul 22 2025

    In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

    Timestamps

    00:56 – What is Alpha-1 antitrypsin deficiency?

    01:45 – Mechanism of this genetic disorder

    03:12 – What makes Alpha 1 so hard to spot?

    04:30 – Genetic complexities of Alpha 1

    06:00 – Risk factors
    Más Menos
    7 m
  • Onc Now: Episode 21: Redesigning Cancer Care Through Precision Medicine

    Onc Now: Episode 21: Redesigning Cancer Care Through Precision Medicine
    Jul 18 2025
    In this episode of Onc Now, host Jonathan Sackier is joined by Jean Abraham, Professor of Precision Breast Cancer Medicine at the University of Cambridge, to delve into the future of integrated cancer medicine, the evolving role of clinical trials, and how precision oncology is redefining outcomes for patients with breast cancer across the UK. Timestamps 00:00 – Introduction 01:28 – Quickfire round 09:50 – Cambridge institutes for precision medicine 12:53 – Predictive/prognostic tools in breast cancer 15:33 – The future of breast cancer clinical trials 18:34 – Integrating genomic data 22:31 – Addressing cost barriers 24:22 – How AI is transforming breast cancer care 28:08 – Why oncology? 30:04 – A message to non-oncologists 31:54 – Abraham’s three wishes for healthcare
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    35 m
  • Hema Now: Episode 21 The Global Perspectives on Myeloma

    Hema Now: Episode 21 The Global Perspectives on Myeloma
    Jul 11 2025
    In this episode, Jonathan Sackier welcomes Claudio Cerchione, haematologist and researcher at the Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. From his early interest in plasma cell disorders, Cerchione shares key insights into the evolution of multiple myeloma (MM) research, the rising role of minimal residual disease (MRD), and promising developments in monoclonal antibodies and CAR-T therapy. He also reflects on standout moments from recent European Hematology Association (EHA) Congress and American Society of Clinical Oncology (ASCO) Annual Meeting, and shares his hopes for the future of haematology. Timestamps: 2:14: Memorable career experiences for Claudio 4:20 Biggest breakthrough in MM 5:10 Interest in plasma cell disorders 6:30 A surprising fact about multiple myeloma 7:40 Claudio’s top choice for a dinner party guest 10:30 The importance of MRD in haematology 13:00 Monoclonal antibodies and CAR-T therapies 19:00 Current challenges 22:22 Claudio’s key EHA and ASCO takeaways 28:30 Claudio’s three magic wishes
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    33 m
  • From Fractures to Futures: Deep Dive Part 2

    From Fractures to Futures: Deep Dive Part 2
    Jul 10 2025

    In this three-part series, Jonathan Sackier sits down with Professor Zoë Paskins to explore the complexities and advancements in rheumatology and bone health. From her personal journey into the field to innovations in managing osteoporosis and arthritis, Zoë offers compelling insights into the current landscape and future of musculoskeletal care.

    Timestamps:

    0:25 - What’s new in osteoporosis management?

    5:05 - Key challenges in addressing gaps in care
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    7 m