This episode does a deep dive into a comprehensive 2026 position stand from The International Society of Sports Nutrition regarding the impact of antioxidants on physical performance and recovery.

Gonzalez DE, Dickerson BL, Roberts BM, et al. International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance. J Int Soc Sports Nutr. 2026;23(1):2629828. doi:10.1080/15502783.2026.2629828

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This episode does a deep dive into an article on Nicotinamide adenine dinucleotide (NAD+), which is an essential coenzyme that facilitates vital biological processes such as energy production, DNA repair, and metabolic balance. Because NAD+ levels naturally decline with age, researchers are investigating various precursors like NR and NMN, alongside enzyme inhibitors, to restore cellular health.

Yusri K, Jose S, Vermeulen KS, Tan TCM, Sorrentino V. The role of NAD+ metabolism and its modulation of mitochondria in aging and disease. npj Metab Health Dis. 2025;3:26. doi:10.1038/s44324-025-00067-0

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This episode does a deep dive into a research paper that examines whether Valentine’s Day influences the occurrence of myocardial infarctions, or heart attacks, among adults in Quebec.

Auger N, Bilodeau-Bertrand M, Ayoub A, Potter BJ. Matters of the heart: case-crossover analysis of myocardial infarction on Valentine’s Day. CJC Open. 2021;3:1075-1078. doi:10.1016/j.cjco.2021.03.013

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This episode dissects a paper that examines exercise as a treatment for depression.

Clegg AJ, Hill JE, Mullin DS, et al. Exercise for depression. Cochrane Database Syst Rev. 2026;1:CD004366. doi:10.1002/14651858.CD004366.pub7

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This episode dissects a review paper that evaluates physical therapy for ALS, finding that multimodal and pulmonary interventions offer modest benefits for functional and respiratory health.

Macpherson CE, Wani DK, Li H, et al. Physical Therapist Interventions for People With Amyotrophic Lateral Sclerosis Across Disease Stages: A Systematic Review of Efficacy. Phys Ther. 2026;106(1):pzaf142. doi:10.1093/ptj/pzaf142.

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This episode does a deep dive into a study showing how creatine monohydrate improves vascular function in older adults.

Clarke HE, Akhavan NS, Behl TA, Ormsbee MJ, Hickner RC. Effect of creatine monohydrate supplementation on macro- and microvascular endothelial function in older adults: a pilot study. Nutrients. 2024;17(1):58. doi:10.3390/nu17010058

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This episode dissects a Mendelian randomization study that identifies a high body mass index (BMI) as a causal risk factor for vascular-related dementia.

Nordestgaard LT, Luo J, Emanuelsson F, et al. High body mass index as a causal risk factor for vascular-related dementia: a Mendelian randomization study. J Clin Endocrinol Metab. Published online January 22, 2026. doi:10.1210/clinem/dgaf662

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This episode dissects a randomized clinical trial that investigated whether weighted vest use or resistance training could prevent the bone density loss typically caused by intentional weight reduction in older adults with obesity. Over a 12-month period, researchers compared a diet-only group to groups adding either a weighted vest or supervised exercise to their regimen.

Beavers KM, Lynch SD, Fanning J, et al. Weighted vest use or resistance exercise to offset weight loss–associated bone loss in older adults: a randomized clinical trial. JAMA Netw Open. 2025;8(6):e2516772. doi:10.1001/jamanetworkopen.2025.16772

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