Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:32 Mancini interview
• 02:26 Anticholinergic burden method of action
• 02:58 Balancing the impact of side effects in schizophrenia treatment
• 04:52 Limitations
• 05:34 The need for further studies
• 05:59 Clinical implications
• 06:32 Further research
• 07:01 Trials needed
• 07:54 Kalin interview
• 08:03 Mancini et al.
• 11:23 Tiihonen et al.
• 13:43 Zhou et al.
• 16:28 Omlor et al.
• 18:51 Orhan et al.

Transcript

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Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:45 Horan interview
• 03:15 Novel mechanism of action in the treatment of schizophrenia
• 05:39 Side effect profiles
• 07:20 Clinical impacts
• 08:31 The need for further investigation
• 09:58 Limitations
• 11:05 Further research
• 13:08 Kalin interview
• 13:21 Horan et al.
• 17:34 Levenstein et al.
• 19:00 Fountoulakis et al.
• 20:57 Couture et al.
• 23:18 Stern et al.
• 27:35 McGirr et al.

Transcript

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Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction.

• 00:35 King interview
• 00:45 Allostatic model of addiction
• 02:12 Gathering data and the groups studied
• 07:37 The ethics of studying alcohol use in patients with AUD
• 10:38 Findings
• 13:29 The impacts of alcohol’s pleasurable effects on people with AUD and those without
• 14:32 Limitations of natural environment research versus laboratory research
• 18:18 Clinical implications
• 20:09 Further research
• 22:56 Kalin interview
• 23:03 King et al.
• 26:21 Brand et al.
• 28:12 Conway et al.
• 32:17 Kypriotakis et al.
• 35:42 Kuhn et al.
• 39:37 Grilo et al.

Transcript

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Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment.

• 00:38 Nemeroff interview
• 02:27 McIntyre et al.
• 04:06 Ramaekers et al.
• 05:44 Ghaznavi et al.
• 08:01 Fonzo et al.
• 09:17 Wolfgang et al.
• 10:45 Psychedelics and psychotherapies
• 12:31 Aaronson et al.
• 14:17 Pagni et al.
• 15:31 Kirlić et al.
• 17:06 Olson

Transcript

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Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP.

• 00:36 Grey and Knight interview
• 02:41 Demographics of the cohort
• 03:46 Neurobiological mechanisms of discrimination impacts
• 06:14 Racial discrimination and mental health impacts
• 09:34 Discrimination as a chronic stressor and prolonged activation of the stress response system
• 10:45 Limitations
• 13:52 Further research
• 14:38 Kalin interview
• 14:52 Grey et al.
• 17:35 Sippel et al.
• 18:06 Fox and Shackman
• 19:42 Kliemann et al.
• 22:16 Kamboj et al.
• 27:07 Pathak et al.

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Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of the All of Us cohort. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the November issue, which takes a close look at issues surrounding substance use disorders.

• 00:41 Le interview
• 01:52 Disparities in treatment of AUDs in the US
• 03:43 What is the VA system doing right?
• 05:25 All of Us
• 06:39 Immediate clinical implications
• 08:15 Limitations
• 09:38 Further research
• 10:55 Kalin interview
• 11:07 Le et al.
• 13:44 Imperio et al.
• 14:43 McClure et al.
• 17:23 Perlman et al.
• 20:57 Savage et al.
• 24:17 Compton et al.

Transcript

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Dr. Bodyl Brand (Oxford University, UK) joins AJP Audio to discuss the effectiveness of menopausal hormone therapy in preventing psychosis relapse in women with schizophrenia and schizoaffective disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the October issue of the American Journal of Psychiatry, which focuses on other issues touching psychosis and schizophrenia spectrum disorders.

• 01:05 Brand interview
• 03:08 MHT and potential side effects in schizophrenia treatment
• 06:16 Estrogen and psychosis prophylaxis
• 07:44 MHT effectiveness
• 10:15 Clinical implications
• 11:27 Strengths and limitations
• 13:47 The need for further study
• 15:54 Further research
• 17:24 Kalin interview
• 17:47 Brand et al.
• 20:17 Partanen et al.
• 23:54 Moran et al.
• 26:48 Gallucci et al.
• 30:38 Arion et al.

Transcript

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Dr. Jessica Salvatore (Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey) joins AJP Audio to discuss peer social genetic effects and their impact on alcohol and substance use, anxiety, and major depressive disorders in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the September issue of the American Journal of Psychiatry.

• 00:52 Salvatore interview
• 02:49 Can the genetic makeup of other people impact your risk for psychiatric conditions?
• 04:12 Impact on genetic predisposition
• 05:12 Why look at these effects through a genetic lens?
• 07:17 Limitations
• 10:05 Clinical implications
• 12:40 Further research
• 13:32 Kalin interview
• 13:47 Salvatore et al.
• 15:54 Dalhuisen et al.
• 19:23 Hess et al.
• 24:14 Larsen et al.
• 26:43 Schwippel et al.

Transcript

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