Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context.

• 00:31 Perlis interview
• 02:56 Lack of validation in screening methods
• 04:03 Stumbling blocks on the road to validation
• 05:10 Synergy between screening scores and machine learning models
• 06:36 Issues with clinician adoption?
• 08:44 Administrative burden for running these models
• 10:38 Current clinical application
• 12:37 Screening without those with a history of depression
• 13:48 Limitations
• 15:30 Future research
• 17:26 Kalin interview
• 17:41 Clapp et al.
• 21:41 Kępińska et al.
• 25:19 Savitz et al.
• 25:25 Miller
• 28:38 Wall et al.

Transcript

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Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context.

• 00:38 Ruggiero interview
• 03:13 Bounce Back Now app
• 05:03 Natural disasters and other sources of trauma
• 07:31 Low cost and broad-based intervention
• 08:49 Limitations
• 10:19 Changes in how the intervention was designed
• 11:17 Uptake and interactions with the app
• 13:15 Future directions
• 14:36 Kalin interview
• 14:50 Ruggiero et al.
• 19:26 Norman et al.
• 23:29 Conrod et al.
• 27:53 Olfson et al.
• 31:44 Olfson et al.

Transcript

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Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:32 Mancini interview
• 02:26 Anticholinergic burden method of action
• 02:58 Balancing the impact of side effects in schizophrenia treatment
• 04:52 Limitations
• 05:34 The need for further studies
• 05:59 Clinical implications
• 06:32 Further research
• 07:01 Trials needed
• 07:54 Kalin interview
• 08:03 Mancini et al.
• 11:23 Tiihonen et al.
• 13:43 Zhou et al.
• 16:28 Omlor et al.
• 18:51 Orhan et al.

Transcript

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Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:45 Horan interview
• 03:15 Novel mechanism of action in the treatment of schizophrenia
• 05:39 Side effect profiles
• 07:20 Clinical impacts
• 08:31 The need for further investigation
• 09:58 Limitations
• 11:05 Further research
• 13:08 Kalin interview
• 13:21 Horan et al.
• 17:34 Levenstein et al.
• 19:00 Fountoulakis et al.
• 20:57 Couture et al.
• 23:18 Stern et al.
• 27:35 McGirr et al.

Transcript

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Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction.

• 00:35 King interview
• 00:45 Allostatic model of addiction
• 02:12 Gathering data and the groups studied
• 07:37 The ethics of studying alcohol use in patients with AUD
• 10:38 Findings
• 13:29 The impacts of alcohol’s pleasurable effects on people with AUD and those without
• 14:32 Limitations of natural environment research versus laboratory research
• 18:18 Clinical implications
• 20:09 Further research
• 22:56 Kalin interview
• 23:03 King et al.
• 26:21 Brand et al.
• 28:12 Conway et al.
• 32:17 Kypriotakis et al.
• 35:42 Kuhn et al.
• 39:37 Grilo et al.

Transcript

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Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment.

• 00:38 Nemeroff interview
• 02:27 McIntyre et al.
• 04:06 Ramaekers et al.
• 05:44 Ghaznavi et al.
• 08:01 Fonzo et al.
• 09:17 Wolfgang et al.
• 10:45 Psychedelics and psychotherapies
• 12:31 Aaronson et al.
• 14:17 Pagni et al.
• 15:31 Kirlić et al.
• 17:06 Olson

Transcript

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Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP.

• 00:36 Grey and Knight interview
• 02:41 Demographics of the cohort
• 03:46 Neurobiological mechanisms of discrimination impacts
• 06:14 Racial discrimination and mental health impacts
• 09:34 Discrimination as a chronic stressor and prolonged activation of the stress response system
• 10:45 Limitations
• 13:52 Further research
• 14:38 Kalin interview
• 14:52 Grey et al.
• 17:35 Sippel et al.
• 18:06 Fox and Shackman
• 19:42 Kliemann et al.
• 22:16 Kamboj et al.
• 27:07 Pathak et al.

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Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of the All of Us cohort. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the November issue, which takes a close look at issues surrounding substance use disorders.

• 00:41 Le interview
• 01:52 Disparities in treatment of AUDs in the US
• 03:43 What is the VA system doing right?
• 05:25 All of Us
• 06:39 Immediate clinical implications
• 08:15 Limitations
• 09:38 Further research
• 10:55 Kalin interview
• 11:07 Le et al.
• 13:44 Imperio et al.
• 14:43 McClure et al.
• 17:23 Perlman et al.
• 20:57 Savage et al.
• 24:17 Compton et al.

Transcript

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