Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

• 00:53 Doxycycline and the risk of developing schizophrenia
• 04:03 Emulated target trials versus randomized control trials
• 06:43 Methods of action
• 09:24 Dosage and exposure levels for doxycycline
• 10:15 Immediate clinical applications
• 10:56 Limitations of the study
• 11:33 Future research
• 12:43 Kalin interview
• 13:00 Lång et al.
• 19:43 Zhao et al.
• 25:20 Metrik et al.

Transcript

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This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025.

• 00:39 Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al.
• 06:23 Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al.
• 11:17 Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al.
• 15:35 David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D.
• 17:27 William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al.
• 24:04 Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al.
• 26:06 Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al.
• 30:26 Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al.

Transcript

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Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

• 00:31 Linke interview
• 02:15 State or a trait?
• 04:15 Neural efficiency and CBT
• 05:22 Potential as a biomarker
• 07:08 Patient-rated and parent-rated measures of anxiety
• 08:16 Immediate clinical implications
• 09:50 Limitations
• 10:43 Future directions of research
• 11:44 Kalin interview
• 11:50 Linke et al.
• 15:16 Mallard et al.
• 18:11 Naples et al.
• 21:44 Mac Giollabhui et al.

Transcript

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.

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Listen to other podcasts produced by the American Psychiatric Association.

Browse articles online.

How authors may submit their work.

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E-mail us at ajp@psych.org