Human Genetics

In our unique genomes, every one of us carries the story of our species - births, deaths, disease, war, famine, migration, and a lot of sex. But those stories have always been locked away - until now. Who are our ancestors? Where did they come from? Geneticists have suddenly become historians, and the hard evidence in our DNA has completely upended what we thought we knew about ourselves. Acclaimed science writer Adam Rutherford explains exactly how genomics is completely rewriting the human story - from 100,000 years ago to the present.

Written by experts and authorities in the field and professionally narrated for easy listening, this crash course is a valuable tool both during school and when preparing for the USMLE, or if you're simply interested in the subject. The audio is focused and high-yield, covering the most important topics you might expect to learn in a typical medical school human genetics course. Included are both capsule and detailed explanations of critical issues and topics you must know to master human genetics.

The thesis of Human Diversity is that advances in genetics and neuroscience are overthrowing an intellectual orthodoxy that has ruled the social sciences for decades. The core of the orthodoxy consists of three dogmas: Gender is a social construct. Race is a social construct. Class is a function of privilege. The problem is that all three dogmas are half-truths. They have stifled progress in understanding the rich texture that biology adds to our understanding of the social, political, and economic worlds we live in. It is not a story to be feared. But it is a story that needs telling.

Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.

Evolutionary theory has long established that humans are animals: Modern Homo sapiens are primates who share an ancestor with monkeys and other great apes. Our genome is 98 percent identical to a chimpanzee's. And yet we think of ourselves as exceptional. Are we? In this original and entertaining tour of life on Earth, Adam Rutherford explores the profound paradox of the "human animal".

There are rare moments in time when we make choices that irreversibly change the world, and our lives, forever. Today is one of those moments. Scientists, engineers and philosophers alike warn us that without a radical shift in our thinking, we are on track to be the last generation of pure humans that the world will know. Within a single generation we will devolve into a hybrid species of synthetic bodies, Artificial Intelligence (AI), and computer chips that limit our ability to think, to love, and to adapt to the conditions of the emerging world in a healthy way.

The Art of Letting Go is all about organizing the mess in your mind. It's about how to stop focusing on the past that is over, or the future that may never occur, and being present in the situations that you can actually have agency in.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

In this groundbreaking work, evolutionary biologist Jared Diamond stunningly dismantles racially based theories of human history by revealing the environmental factors actually responsible for history's broadest patterns. It is a story that spans 13,000 years of human history, beginning when Stone Age hunter-gatherers constituted the entire human population. Guns, Germs, and Steel is a world history that really is a history of all the world's peoples, a unified narrative of human life.

Over the last century, the search for human ancestors has spanned four continents and resulted in the discovery of hundreds of fossils. While most of these discoveries live quietly in museums, there are a few that have become world-renowned celebrity personas. In Seven Skeletons, historian of science Lydia Pyne explores how seven such famous fossils of our ancestors have the social cachet they enjoy today.

V. S. Ramachandran is at the forefront of his field - so much so that Richard Dawkins dubbed him the "Marco Polo of neuroscience". Now, in a major new work, Ramachandran sets his sights on the mystery of human uniqueness. Taking us to the frontiers of neurology, he reveals what baffling and extreme case studies can teach us about normal brain function and how it evolved.

You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.

Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it - a French convent girl who found herself changing sex at puberty; children who, echoing Homer's Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity.

Having done field work in New Guinea for more than 30 years, Jared Diamond presents the geographical and ecological factors that have shaped the modern world. From the viewpoint of an evolutionary biologist, he highlights the broadest movements both literal and conceptual on every continent since the Ice Age, and examines societal advances such as writing, religion, government, and technology.

In this landmark book of popular science, Daniel E. Lieberman - chair of the department of human evolutionary biology at Harvard University and a leader in the field - gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.

Just over 125,000 years ago, humanity was going extinct until a dramatic shift occurred—Homo sapiens started tracking the tides in order to eat the nearby oysters. Before long, they’d pulled themselves back from the brink of extinction. The human brain, and its evolutionary journey, is unlike anything else in history. In A History of the Human Brain, Bret Stetka takes listeners through that far-reaching journey. He also tackles the question of where the brain will take us next, exploring the burgeoning con­cepts of epigenetics and new technologies like CRISPR.

What is human consciousness, and how is it possible? This question fascinates thinking people from poets and painters to physicists, psychologists, and philosophers. From Bacteria to Bach and Back is Daniel C. Dennett's brilliant answer, extending perspectives from his earlier work in surprising directions, exploring the deep interactions of evolution, brains, and human culture.

Equal parts Sapiens, Behave, and Superintelligence, but wholly original in scope, A Brief History of Intelligence offers a paradigm shift for how we understand neuroscience and AI. Artificial intelligence entrepreneur Max Bennett chronicles the five “breakthroughs” in the evolution of human intelligence and reveals what brains of the past can tell us about the AI of tomorrow.

In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer.

Humans are a puzzling species. On the one hand, we struggle to survive on our own in the wild, often failing to overcome even basic challenges, like obtaining food, building shelters, or avoiding predators. On the other hand, human groups have produced ingenious technologies, sophisticated languages, and complex institutions that have permitted us to successfully expand into a vast range of diverse environments. What has enabled us to dominate the globe, more than any other species, while remaining virtually helpless as lone individuals?