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For our 13th annual celebration of people who are driving the next generation of technological breakthroughs, we’re presenting the stories in a new way. We’ve grouped them by categories that reflect the variety of approaches that people can take to big problems. First we introduce you to Inventors, who are creating new technologies. Next come Entrepreneurs, who are turning technologies into viable businesses. Then meet the Visionaries, who are anticipating how technologies can make life better, while Humanitarians are concentrating on expanding opportunities. Finally, the Pioneers are exploring new frontiers, setting the stage for future innovations.

In this issue, you’ll learn why Silicon Valley has never been successfully reproduced. You’ll hear the secret to becoming the next tech hot spot. You’ll learn how Beijing is being turned into a technology powerhouse….

Technology Review is the United State's oldest technology magazine. And in the last few years, TR has undergone a dramatic transformation, shifting its focus to innovation - the process by which humanity continuously upgrades its tools and techniques. Each issue concentrates on four major fields of innovation: biotechnology, information technology, material science, and nanotechnology.

In this issue, you’ll hear what happened when one man pinged the whole internet. You’ll hear why Google is breaking its own restrictions. You’ll learn how researchers have come up with a way to mine cell-phone data while avoiding privacy pitfalls. You’ll hear why companies that make industrial control systems have finally begun to pay more attention to security issues. You’ll learn about Florida’s first full-scale smart grid technology system. And you’ll hear news from the worlds of Biomedicine, Technology and Communications.

In this issue, you’ll learn how Artificial intelligence is finally getting smart. You’ll hear about the next frontier of the genome revolution. You’ll learn about a maverick neuroscientist who believes he has deciphered the code by which the brain forms long-term memories. You’ll hear about the debate over what our responsibilities and duties are to help safeguard the distant future from global warming. And you’ll learn why we need technology that enhances human drivers’ abilities rather than making those abilities increasingly obsolete.

In this issue, you’ll learn how developing nations are putting nuclear on fast-forward. You’ll hear about a new kind of molten-salt reactor that is designed to overcome the major barriers to nuclear power. You’ll learn why securing critical infrastructure needs to go far beyond the measures in President Obama’s executive order. You’ll hear how the sequencing of a complete human genome may soon cost less than an iPhone. You’ll learn about Facebook’s database that describes as many things as possible.

You’ll hear how pro-manufacturing advisors have the ear of the president. You’ll hear how robots could be replacing low-wage workers. You’ll learn how breakthroughs in hardware and software brought us usability advances, faster chips, and gesture control. You’ll hear two articles on China’s technological outlook for the year. You’ll learn about a new processor that could help usher in the next wave of mobile communication breakthroughs. And you’ll hear news from the worlds of Biomedicine, Technology and Communications.

In this issue, you’ll learn how one man may have just started a race to discover alien life on the Red Planet. You’ll hear about a jamming technique that could take out an entire city’s mobile service. You’ll learn why Microsoft may be invading China’s smart-phone market. You’ll hear about Microsoft’s mobile era dilemma. You’ll hear three different articles about online education. And you’ll hear news from the worlds of Biomedicine, Technology and Communications.

In this issue, learn why we are having difficulties solving the big problems. You’ll learn about United States’ plan of sending astronauts to Mars in 2030. You’ll hear about the looming Alzheimer's health-care disaster. You’ll learn whether online colleges are just a fad or the change that higher education needs. And you’ll learn how solar-powered microgrids could help bring power to millions of the World’s poorest.

In this issue, you’ll hear how venture capital has failed to be the financial engine of American innovation. You’ll learn why a research agency’s shift in focus to alternative energy has put them in the political crosshairs. You’ll hear how a blood test could herald in a new wave of noninvasive prenatal screenings. You’ll learn how market leaders can quickly turn into market has-beens.

Welcome to Technology Review’s Special Edition for September 2012 on the 35 Innovators Under the Age of 35. Some members of our latest list of young innovators from around the world have developed consumer Web services you might have used, such as Spotify or Dropbox. Others are making more fundamental breakthroughs that have yet to be commercialized, such as more efficient engines or improvements in optical communications. And a few are blazing trails in fields that didn’t exist before, like pop-up fabrication of tiny machines, or cameras that can see around corners. But all 35 of them have something significant in common: their work is likely to be influential for a very long time. We hope that these stories about them surprise and inspire you.

In this issue, you’ll hear about the future of the computer industry. You’ll learn why Google’s Nexus 7 is going to make plenty of friends. You’ll hear why the advertising industry is battling some of technology’s biggest companies. You’ll learn whether Europe's strict stance on protecting people's data is costing businesses or creating new opportunities. You’ll hear how candidates are matching voter records with sophisticated online tracking to target their ads. And you’ll hear news from the worlds of Biomedicine, Technology and Communications.

In this issue, you’ll hear about whether we could take a cut of the billions companies are making due to their knowledge of our online habits. You’ll learn about an app that can figure out who your cell-phone camera is pointed at. You’ll hear how fitness trends and health-care problems are creating a demand for tiny computers we won't even notice we're carrying. You’ll hear how an innovative motion-sensing technology is achieved by combining clever software with the Doppler Effect.

You’ll learn about the TR10, the 10 most important technological milestones reached in the last 12 months. You’ll hear about the tribulations involved in creating a public repository of every book ever published. You’ll learn how social communications played a big part on the war against Qaddafi. And you’ll find out why Apple’s iPhone app, Siri works so well.

You’ll learn how local programmers and homegrown business models are helping to realize the vast promise of using phones to improve health care and save lives. You’ll hear how an Internet pioneer’s quest to quantify everything about his health led him to a startling discovery. You’ll learn how personalized cancer treatment may have finally arrived. You’ll hear how a startup is trying to reinvent computer networking in an effort to make Internet services smarter, faster, and cheaper.

In this issue, you’ll learn how antipiracy legislation could be fraught with downsides. You’ll hear how a nonprofit organization that holds millions of pieces of academic work will soon let the public see it for free. You’ll learn why defending against a cyber-attack is so hard that some think a stronger offense is required. You’ll hear how a memory-storage element made at IBM Research points to future computing systems built atom by atom.

In this issue, you’ll hear how a new book about Google offers some fascinating inside details. You'll learn how recent infighting has done little to explain how Anonymous operates – or what drives it. You’ll hear about the story behind Intel's new design. You'll learn how mobile phones are now starting to influence the operating systems of the traditional desktops they once imitated.

In this issue, you'll hear how physicians can now use DNA sequencing to uncover the causes of rare genetic disorders. You'll learn about an online community where people are free to be wrong – and how big investors want a piece of the action. You'll hear about the dilemma that new energy technologies could face once the federal stimulus funds have dried up.

In this issue, you'll hear how researchers are pursuing radical new ways to eliminate AIDs. You'll learn what the recent increase in cyber attacks can teach us about thwarting cyber crime, espionage and warfare. You'll hear about a billionaire who is attempting to make solar power a commonplace and affordable source of energy. And you'll learn how the FCC is planning to improve internet connectivity in an effort to help boost the economy.

In this issue, you'll learn how a startup is making a new entry in the race to build the virtual personal assistant. You'll hear how Wikipedia is trying to transform itself into an essential part of Web 3.0. You'll learn about a new service that makes it easy to access photos, video, and music from almost any Web-connected device. And you'll hear about the recent advances in renewable energy for cars and other forms of transportation.