Mostrando títulos en Química

Two students explain chemistry in an easy and understandable way.

A workshop held last June by the National Institutes of Health (NIH) Director’s Office, Nature Publishing Group, and Science focused on the role that journals play in supporting scientific research that is reproducible, robust, and transparent. The “Principles and Guidelines for Reporting Preclinical Research” that emerged from the workshop have since been endorsed by nearly 80 societies, journals, and associations.VOL.290,NO.50,pp.29692–29694 - 2015

Bierklap is een maandelijkse podcast over bier! Met uw gastheren, Jordi Bruynseels & Pieter de Bock Deze maand praten we over volgende items: Intro (00:00:00 - 00:01:22)Maandgasten: Yannick Boelens - Brouwerij Boelens (00:01:22 - 00:42:20)Beerstyles! Rauchbier (00:42:20- 00:57:45)Bier van de maand: Tripel Klok (00:57:45- 01:07:31)Wist je Datjes: Implosie (01:07:31- 01:16:05)Bier Actua: Verslag van De Belgische Brouwers (01:16:05- 01:35:30) #hetanker# #batteliek #goudencarolus #brouwerijdebock #bierklap

The gender imbalance in science, technology, engineering, and math (STEM) fields has remained constant for decades and increases the farther up the STEM career pipeline one looks. Why does the underrepresentation of women endure? This study investigated the role of parenthood as a mechanism of gender-differentiated attrition from STEM employment. Using a nationally representative 8-year longitudinal sample of US STEM professionals, we examined the career trajectories of new parents after the birth or adoption of their first child. We found substantial attrition of new mothers: 43% of women ...

This podcast, born from Horizon2020's Green Deal initiative, pushes boundaries in the fight against climate change. Guided by Dr. Schwan Hosseiny, project lead of ECO2Fuel and CEO of CENmat, you'll be exposed to ground-breaking research and cutting-edge solutions. Each episode involves rich conversations with industry experts on the latest carbon capture breakthroughs, weaving together the intricate worlds of science, tech, and policy. Our podcast caters to everyone. From advocates and researchers to policymakers and the simply curious, there's something for all. Be ready to widen your ...

A podcast for creatives that dives into the science behind how different art materials work to create art.

Welcome to the Safer Chemicals Podcast, where we delve into the world of chemical risk management. In this episode, we speak with Tim Bowmer and Maria Ottati, Chairs of ECHA's Risk Assessment and Socio-Economic Analysis Committees. They update us on the universal PFAS restriction proposal, an ambitious initiative to minimise the release of persistent chemicals. Tim Bowmer also reflects on his impressive 11 years as Chair and sheds light on the evolving regulatory landscape. Join us as we explore the latest developments and discuss the future challenges faced by ECHA's committees. What ...

Welcome to "The Pathfinder," your audio guide through the ever-changing landscape of regulatory developments, compliance trends, and updates. Delve into the world of industry insights, best practices, and expert analysis as we bring you the latest information to help you navigate the complexities of the regulatory environment. "The Pathfinder" is your trusted companion, illuminating the path to success by highlighting relevant topics that impact businesses and organizations. Our audiocasts feature articles written by field experts, ensuring accuracy and providing invaluable insights to sponsor...

Join us in this episode of the Safer Chemicals Podcast as we explore the latest developments from the Enforcement Forum of the European Chemicals Agency (ECHA). In conversation with Katja vom Hofe, the outgoing Chair of the Forum, we reflect on the achievements and challenges faced in promoting chemical safety and enforcement. Discover how the Forum's collaborative efforts have shaped the future of chemical regulation in Europe and learn about the upcoming REACH enforcement project, REF-13. We dive into the topic of enforcing chemical products sold online, exploring the scope, impact, ...

Human tissues are invaluable resources for pharmaceutical research. They provide information about disease pathophysiology - and equally importantly, healthy function; confirmation (or refutation) of potential drug targets; validation (or otherwise) of other models employed; and functional models for assessing drugs’ effects, whether beneficial or undesirable, in the most appropriate environment that can be replicated outside the human body. While human tissues have long been prized by pathologists in furthering our under- standing of disease processes, there is a growing appreciation of ...

Albert Einstein once eloquently stated “We still do not know one thousandth of one percent of what nature has revealed to us.” Mother Nature has proven time and again to be the best engineer, architect, scientist, and doctor. This fact has not been lost on mankind, and since time immemorial, we have looked to nature for answers to human conditions and diseases. Indeed, our first evidence dates back to preliterary history as long as 50,000 years ago, in archaeological discoveries from a Middle Eastern grave site at Shanidar, Iraq, of a Neanderthal man which contained plant specimens, of ...

Triple negative breast cancer (TNBC) remains a therapeutic challenge due to the lack of targetable genetic alterations and the frequent development of resistance to the standard cisplatin-based chemotherapies. Here, we have taken a systems biology approach to investigate kinase signal transduction networks that are involved in TNBC resistance to cisplatin. Treating a panel of cisplatin- sensitive and cisplatin-resistant TNBC cell lines with a panel of kinase inhibitors allowed us to reconstruct two kinase signalling networks that characterise sensitive and resistant cells. The analysis of ...

Tudomány és élet közötti kapcsolatot járjuk körbe vendégeinkkel.

This episode gives you the highlights from the June meeting of our Biocidal Products Committee. Our guest is the Chair of the committee, Erik van de Plassche. In this episode we cover, for example, topical active substance and Union authorisation cases. We also discuss some procedural topics related to data that is generated after an active substance has been approved as well as minor and major change applications in the context of Union authorisations. We also take a broader look at the work of the committee and hear Erik’s reflections on how it has developed during the past ten years, ...

Meta-research, or the science of science, is a powerful technique that scientists can use to improve science, however most scientists are unaware that meta-research exists and courses are rare. This initiative demonstrates the feasibility of a participant-guided “learn by doing” approach, in which a multidisciplinary, global team of early career researchers learned meta-research skills by working together to design, conduct and publish a meta-research study.https://doi.org/10.1371/journal.pbio.3001073 - 2021

Mechanically interlocked molecules such as rotaxanes and catenanes contain free-moving components that cannot dissociate and have enabled the investigation and control of various translational and rotational molecular motions. The architecture of pseudo-rotaxanes and of some kinetically labile rotaxanes is comparable to that of rotaxanes but their components are reversibly associated and not irreversibly interlocked. In other words, pseudo-rotaxanes may fall apart. This Account focuses on a peculiar family of rotaxane-like architectures termed foldaxanes. Foldaxanes consist of a helically ...

[Ru(phen)2 (dppz)]2+ has been studied since the 1990s due to its ‘light-switch’ properties. It can be used as a luminescent DNA probe, with emission switched on through DNA binding. The luminescence observed is dependent on the solvent accessibility of the pyrazine nitrogen atoms, and therefore is sensitive to changes in both binding site of the cation and chromophore orientation. The compound is also chiral, and there are distinct differences between the enantiomers in terms of the emission behaviour when bound to a variety of DNA sequences. Whilst a number of binary DNA-complex X-ray ...

The movement towards open science is a consequence of seemingly pervasive failures to replicate previous research. This transition comes with great benefits but also significant challenges that are likely to affect those who carry out the research, usually early career researchers (ECRs). Here, we describe key benefits, including reputational gains, increased chances of publication, and a broader increase in the reliability of research. The increased chances of publication are supported by exploratory analyses indicating null findings are substantially more likely to be published via open ...

We describe an isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5' exonuclease, a DNA polymerase and a DNA ligase. First we recessed DNA fragments, yielding single-stranded DNA overhangs that specifically annealed, and then covalently joined them. This assembly method can be used to seamlessly construct synthetic and natural genes, genetic pathways and entire genomes, and could be a useful molecular engineering tool.DOI:10.1038/NMETH.1318 - 2009

Formation of natural intramolecular triple-helical structures of DNA is still an intriguing research topic in view of the possible involvement of these structures in biological processes. The biochemical and biophysical properties of DNA triplex structures have been extensively studied, and experimental data show that H-DNA is likely to form in vivo and may regulate the expression of various genes. However, direct and unambiguous evidence of the possible biological roles of these structures is yet elusive. This review focuses on the basic facts that are in favor of, or against, the hypothesis ...