The Woman Who Couldn't Wake Up

Hypersomnia and the Science of Sleepiness

Sleep was taking over Anna's life. Despite multiple alarm clocks and stimulants, the young lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn't stay awake long enough to eat. Anna's doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.

The Woman Who Couldn't Wake Up tells Anna's story-and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna's successful treatment helped others form a community.

Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is a must-listen for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.

©2023 Quinn Eastman (P)2024 Tantor