Terbinafine! Griseofulvin!

2 weird antifungals that the dermatologists use much more than us!

But we here at the ID:IOTS Podcast love all our antifungal agents equally so here's an episode on literally everything you need to know about both these agents!

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Now this an episode, first of a triple

About all the work of a lab called RIPL

And we'd like to take minute now so sit right here

And learn about all the horrible pathogens you now should fear

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Part 2 of 2 on Echinocandins!

Tihana Bicanic gives a masterclass on Rezafungin, its use now and in the future, and gives an update on the relevant clinical trials and studies you need to know to make you a Master Echinocandologist.

Alyssa and Jame are here too, but very much in receive-only mode. Listen in and find out why!

Notes for this episode are found here: https://idiots.notion.site/132-133-Echinocandins-2d76a1ea09d8811f800ad3a446c6726e

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Alyssa and Jame are joined by Tihana Bicanic, to discuss the second great antifungal drug class, Echinocandins.

Part 1 of 2! (this episode we discuss the old stuff, next episode we discuss Rezafungin in more detail).

Show note for this episode found here: https://idiots.notion.site/132-133-Echinocandins-2d76a1ea09d8811f800ad3a446c6726e

(Note if you have any echo on the audio for this episode, try re-downloading the episode)

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BIOCIDES ARE COMING FOR YOU.

Find out what they are, what the benefits and harms they have, and what we can do to control their use in consumer products.

This was a fascinating, wide-ranging discussion on the use of agents that can affect the human/animal microbiome and environmental microbes, and the problems with trying to regulate them (in the UK at least). Hope you enjoy it.

Bios:

Natalie Bennett has been a Green Party representative in the UK House of Lords for six years, after being leader of the England & Wales Party from 2012-2016. Her first degree - from the University of Sydney - was in agricultural science, and she can get very geeky about soils; she got tardigrades into Hansard (the parliamentary record) for the first time ever in her maiden speech. Her Consumer Products (Control of Biocides) Bill was introduced to the House in January 2025. Her first book is Change Everything: How We Can Rethink, Repair and Rebuild Society, and her second (Green Thinking Unlearning Outdated Ideas in Science, Economics and Politics) will be out from Routledge next April.

Anastasia “Tash” Theodosiou is an Academic Clinical Lecturer at the University of Glasgow and a Specialty Registrar in Microbiology & Infectious Diseases. Her research explores how the microbiome shapes health and disease, with a particular focus on early life; her PhD produced the world’s first human challenge study performed in pregnancy. She also coined the term microbiotoxicity, a framework for recognising the unintended impacts of antimicrobial products on the microbiome, and is a passionate advocate for embedding microbiome stewardship into clinical practice, prescribing, and policy.

Jame is a podcaster. He works for the NHS on occasion.

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Flustered by fluconazole?

An ignoramus on itraconazole and isavuconazole?

Puzzled by Posa? VEXED BY VORI?

Never fear: You can be amazed at the Azoles, just learn how to use 'em right! That's what this episode's all about! Alyssa and Jame UNITE in the first of our episodes on antifungal drugs!

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AKA Penicillin Allergy 3: Delabel Hard With A Vengeance

A departure from our semi-annual penicillin allergy episode: one on cephalosporin allergy!

Jame and Callum are joined by Fionnuala Cox to discuss Cephalosporin allergy in general, and the CEPH-FAST risk assessment tool in particular.

Ever wanted to know how to deal with cephalosporin allergy? Listen on!

Paper here:

Cox F, Vogrin S, Sullivan RP, Stone C, Koo G, Phillips E, et al. Development and validation of a cephalosporin allergy clinical decision rule. Journal of Infection. 2025 June 1;90(6). Available from: https://www.journalofinfection.com/article/S0163-4453(25)00089-1/fulltext

https://doi.org/10.1016/j.jinf.2025.106495

(It's open access, don't worry)

Register for the BIA Spring Meeting 2026 here!

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Yo ho ho, for our listeners dearest

We present an antibiotics tier list

Ranking drugs from S to D

In a manner oh so Christmassy

So sit back relax and have a drink

As we discourse in cladist think

And if you rank a different way

We'll forgive you this Christmas day.

Proper episodes next year. See you in 2026!

Register for the BIA Spring Meeting 2026 here!

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