Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

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It’s an exciting time to be practicing in obesity medicine, with groundbreaking tools like Zepbound and Wegovy helping people achieve their weight loss goals in ways that were once unimaginable. Plus, with new medications like retatrutide (the triple agonists) on the horizon, the future of weight management is looking even brighter.

But with so many options available, it can be overwhelming to figure out which medication is right for you. How do Zepbound and Wegovy compare? Can you switch between the two? Is one more effective than the other? In this episode, I’ll dive into the key differences between Zepbound (Mounjaro) and Wegovy (Ozempic), comparing doses, effectiveness, and answering all your burning questions about how these medications stack up against each other.

References

The Top 5 Mistakes People Make When Starting GLP-1

Season 1 of the Premium Podcast: The Obesity Guide: Behind the Curtain

Audio Stamps

00:30 - Dr. Rentea sets the stage for a back-to-basics breakdown of Wegovy vs. Zepbound, which touches on key topics like switching, dosing, and access.

01:58 - A comparison of Wegovy (GLP-1) and Zepbound (dual GLP-1 and GIP), discussing their average weight loss effects and varying response rates.

05:19 - Dr. Rentea discusses the reasons someone might consider switching medications.

06:45 - Switching medications shouldn’t involve restarting titration, and working with a knowledgeable physician to manage transitions effectively is key.

11:45 - Medication can be a helpful tool, but long-term success depends on working with a skilled physician and staying focused on sustainable progress.

Quotes

“Within the first few months, it's going to become very clear. Do you need an additional tool? Do we need to tweak things? Do we need to change things?”

“These are medications, but they're not everything. You still have to do the heavy lifting on the lifestyle aspect behind the scenes. But you have the ability to switch from one to the other.”

“You really should be working with someone who is very familiar with these medications, with switching medications, with adding other things to it, with changing things. There is always something else that can be done.”

“We do sometimes see higher results with ZepBound, but there's going to be other medication that comes out that's potentially higher than that. At the end of the day, it's what helps me to keep doing all the other things.”

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

Mentioned in this episode:

Instagram recipe: Salt & vinegar potatoes! on claudiaathome

Sound candy that is either fruit based (Final Boss Sour) or high fiber but so delicious (Behave Candy)

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

GLP-1 medications like Mounjaro are transforming the conversation around weight loss and diabetes management, but behind the headlines and medical jargon lies a real journey—one that’s often emotional, confusing, and filled with misconceptions.

In this episode, Dave Knapp, the visionary behind OnThePen.com and the voice of @manonthemounjaro, shares his personal journey with type 2 diabetes and Mounjaro. As someone deeply passionate about reshaping the conversation around GLP-1, obesity, and diabetes, Dave offers valuable insights and heartfelt personal stories.

Join us as we explore the inspiration behind his book, Decoding GLP-1, where Dave breaks down the complexities of GLP-1 medications and shares practical tips for those supporting loved ones on this journey. Learn how to start stigma-free conversations, connect with a supportive community, and understand why there’s no one-size-fits-all solution when it comes to managing obesity.

References

Decoding GLP-1

OnThePen.com

@manonthemounjaro

Audio Stamps

01:11 - Dave Knapp shares how his type 2 diabetes journey and Mounjaro experience sparked the creation of On The Pen.

03:20 - We learn why Dave wrote his “Decoding GLP-1” book—a quick, accessible guide to help loved ones understand GLP-1 meds and reduce the shame around sharing your story.

07:52 - Dr. Rentea asks how to start honest, stigma-free conversations with loved ones about using GLP-1 medication, especially when shame has made it hard to open up.

12:58 - Dave and Dr. Rentea discuss the best ways to start finding a supportive community.

19:32 - Dave offers his top tips for anyone getting started on this journey—and reminds us why there's no one-size-fits-all approach to treating obesity.

Quotes

“The people that have the best voice in this space have a personal experience with it.” - Dr. Rentea

“It broke my heart to hear so many people afraid to share the part of their journey with the people that mattered the most.” - Dave Knapp

“I could see not only family and friends reading this, but actually physicians giving this to their patients because people need it in one area like this.” - Dr. Rentea

“Weight is cosmetic to the rest of the world. They don’t see your A1C, they don’t see your lipid panel, they don’t see your fatty liver. But the reduction of those things is quite a story to tell. “Couching everything around

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

There’s been a lot of buzz lately about how GLP-1 weight-loss drugs like Ozempic and Wegovy are reshaping the food industry. With fewer people craving ultra-processed snacks, Big Food is scrambling to adapt—developing new products to regain lost sales. But can they really outsmart these medications? And what does this mean for your health?

In this episode, we break down how the food industry is pivoting, what’s at stake, and how you can take control—choosing where your money goes and what truly serves your health. Tune in for a deep dive into this shifting food landscape and what it means for you.

References

ReciMe | The Ultimate Cooking App

Devotion Nutrition

A study published in JAMA Health Forum found that obesity prevalence and BMI decreased in the US in 2023, marking the first such decline in over a decade

The Top 5 Mistakes People Make When Starting GLP-1

Audio Stamps

01:00 - Dr. Rentea shares how the ReciMe app makes meal planning effortless and helps her find inspiration for easy, home-cooked meals.

04:13 - Dr. Rentea breaks down how our obesogenic environment makes weight gain almost inevitable without intentional changes.

07:29 - Ultra-processed foods override satiety, driving overeating by design.

12:14 - Aiming for 80% whole foods helps you better notice how ultra-processed foods affect your hunger and cravings.

18:18 - Dr. Rentea shares how processed foods can be helpful in moderation, but whole foods should be the focus.

21:40 - You get to decide where your money goes, whether it’s supporting local farmers or prioritizing higher-quality, whole foods. It's about aligning your choices with your health and values.

Quotes

“We're in a modern world, but we have an ancient brain. And these foods are hyper palatable. It means that you want more of them than if you were to have naturally occurring food.”

“In a climate where the companies do not care about you, you need to care about yourself.”

“If about 80 percent of the time you're relying on whole based foods, you're able to tell more when you have that processed food, how it affects you.”

“It's unrealistic, given that we're in a super hyper-processed environment, that you would never consume any of that.”

“There is no universe where you're going to measure out a portion of chips and you're going to feel like you've had enough. It's not possible.”

“You're not going to win

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us.

You’ve been diagnosed with PCOS, handed a prescription, and sent on your way—but no one explained what’s actually happening in your body. Why does PCOS make it harder to manage weight? Why are cravings and fatigue so relentless? And what does insulin resistance have to do with it?

The truth is, insulin resistance plays a major role in PCOS—yet it’s often misunderstood or overlooked. When your body struggles to use insulin effectively, it can lead to inflammation, weight gain, and an increased risk of diabetes and heart disease. But here’s the good news: small, strategic changes can make a big difference.

In this episode, Dr. Komal Patil-Sisodia, a Triple Board-Certified Endocrinologist and Women’s Metabolic Health Expert, joins us to break down what really works. From movement and nutrition to key supplements, we’ll explore how to manage insulin resistance and take back control of your health. Plus, Dr. Patil-Sisodia shares insights from her new Eastside Menopause & Metabolism Clinic—a practice dedicated to helping women feel their best during perimenopause and menopause.

References

Season 1 of the Premium Podcast: The Obesity Guide: Behind the Curtain

Connect with Dr. Patil-Sisodia:

TikTok

Instagram

Eastside Menopause & Metabolism

01:08 - Today’s guest, Dr. Komal Patil-Sisodia, shares her journey to opening East Side Menopause and Metabolism, highlighting the urgent need for specialized care in menopause and metabolic health.

03:35 - Dr. Patil Sisodia explains insulin resistance, where weight gain, especially around the abdomen, makes it harder for the body to manage blood sugar.

08:25 - We learn the importance of movement in managing insulin resistance.

11:54 - Dr. Patil-Sisodia addresses myths around low-carb diets, highlighting the importance of food pairing to control blood sugar levels.

23:00 - We hear the benefits of strength training and find out why it is key for managing insulin resistance.

28:23 - Dr. Rentea and Dr. Patil-Sisodia discuss how PCOS presents a wide range of symptoms that can vary greatly between individuals.

33:18 - While supplements can be beneficial for some, their effectiveness varies, and they should be used thoughtfully alongside lifestyle changes.

“I reall

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more.

April 30/30 registration.