Toby Maher joins us to discuss results of a randomised, double-blind, placebo-controlled, proof-of-concept trial of ENV-101, an oral inhibitor of the hedgehog signalling pathway, in patients with idiopathic pulmonary fibrosis.

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https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00239-5/fulltext?dgcid=buzzsprout_icw_podcast_September_25_lanres

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Professors Guy Brusselle and Celeste Porsbjerg join us to discuss their recent Series papers on asthma, which will be featured in a cross journal project with The Lancet, published to coincide with a Lancet journal session on asthma at ERS in Amsterdam.

The Series aims to provide an overview of recent research advances related to asthma; to provide new insights into the genetics, prevention and risk factors for asthma; review advances arising as a result of the use of monoclonal antibody therapeutics; and assess remission in adult patients. Late breaking research will also be included within the journal session and linked to the Series.

Read the full Series:

https://www.thelancet.com/series-do/asthma-2025?dgcid=buzzsprout_icw_podcast_asthma25_lanres

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Diana Stanley, Deputy Editor at The Lancet Respiratory Medicine, is joined by Dr Joan Soriano to discuss a new series on the global epidemiology of respiratory disease, exploring the diagnostic challenges, global trends, and future directions for prevention.

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https://www.thelancet.com/series-do/global-epidemiology-chronic-respiratory-disease?dgcid=buzzsprout_icw_podcast_lanrescrd25_lanres

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Carole Mitnick & Lorenzo Guglielmetti join Ari Colosio, deputy editor of The Lancet Respiratory Medicine, to discuss the ENDTB-Q trial to evaluate the efficacy and safety of a drug regiment to treat TB in individuals with pre-extensively drug-resistant tuberculosis.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres

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This episode is in Italian. For the English version, please see the main feed.

Lorenzo Guglielmetti sul trial clinico ENDTB-Q per valutare l’efficacia e la sicurezza di un regime di farmaci per curare la tubercolosi in individui con tubercolosi pre-estesa farmaco-resistente.

Leggi l'articolo completo:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres

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Bianca Brandon is joined by Professor Marcus Schultz and Dr Prashant Nasa to discuss their recent Position Paper reporting insights from an international Delphi expert panel on defining and subphenotyping ARDS. The findings underscore the need to refine the ARDS definition to better address heterogeneity of the condition and improve diagnostic precision, with use of subphenotyping where appropriate.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00115-8/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanres

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Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific patient groups, the importance of biomarker-driven personalised medicine, and the need for improved representation of immunosuppressed patients in clinical trials.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00124-9/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lanres

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