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At a time when anxiety and depression rates are soaring across all age groups, Dr. Mark Pettus cuts through the noise with revelatory insights into how our daily choices shape our mental landscape. This compelling exploration connects the dots between what's on your plate, how you move through your day, and the remarkable resilience of your brain.

Dr. Pettus introduces the concept of allostatic load—how our bodies interpret and respond to environmental stressors—and reveals why our modern lifestyle creates the perfect storm for mental health challenges. Rather than viewing mood disorders as purely psychological phenomena, he presents compelling evidence that insulin resistance, inflammation, and disrupted circadian rhythms form the physiological foundation of many mental health struggles.

The conversation takes a fascinating turn when Dr. Pettus explains how rapid blood sugar fluctuations can trigger symptoms indistinguishable from anxiety attacks. That afternoon panic might actually be the aftermath of your lunch choices! Through practical nutritional principles focused on whole foods, lower glycemic options, and nutrient density, he offers actionable strategies to support neuroplasticity—your brain's remarkable ability to generate new cells and neural pathways throughout life.

Beyond diet, we discover how Brain-Derived Neurotrophic Factor (BDNF)—essentially "miracle grow for the brain"—can be boosted through movement (especially dancing!), natural light exposure, time in nature, and specific foods. The gut-brain connection emerges as another critical pathway, with our microbiome directly influencing neurotransmitter production and mood regulation. Most empowering is the concept of metabolic flexibility—how developing your body's ability to efficiently switch between fuel sources enhances both cognitive function and emotional stability.

Weaving together ancestral wisdom with cutting-edge neuroscience, Dr. Pettus presents a holistic framework that honors our evolutionary design while navigating modern challenges. This isn't about quick fixes or magic pills—it's about building sustainable resilience through aligned lifestyle choices that activate our innate capacity for wellbeing.

Ready to rewire your approach to mental health? Listen now and discover how small, strategic shifts in your daily habits can transform your mind, mood, and quality of life. Your brain was designed to thrive—learn how to give it what it truly needs.

For PowerPoint slide deck: www.thehealthedgepodcast.com

For Essential Provisions Meals Ready to Eat (MREs): www.essentialprovisions.com

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The rhythms of nature have orchestrated human biology for millennia, but our modern lifestyle has disconnected us from these essential patterns. Dr. Mark Pettus takes us on a fascinating journey through the science of circadian rhythms, revealing how light serves as crucial information that synchronizes every cell in our bodies with the natural day-night cycle.

From ancient Hippocrates to Nobel Prize-winning research, the evidence is clear: our bodies respond profoundly to light quality and timing. Yet today, we spend over 90% of our time indoors under artificial lighting that bears little resemblance to natural sunlight. This mismatch disrupts our internal clocks and increases risk for depression, anxiety, obesity, diabetes, cardiovascular disease, and even cancer—all conditions that ancestral cultures living in alignment with natural light cycles rarely experienced.

Dr. Pettus explores how different wavelengths of light trigger specific biological responses. Morning blue light naturally stimulates alertness and cortisol production—precisely what we need to start our day. Evening sunset, with its red-orange spectrum, signals our bodies to reduce cortisol and increase melatonin for restoration and repair. When we expose ourselves to bright blue-rich light after sunset through screens and indoor lighting, we essentially trick our bodies into thinking it's morning, suppressing critical healing processes.

The good news? Simple changes can dramatically improve circadian alignment. Just 5-10 minutes of morning sunlight exposure helps anchor your biological clock. Using appropriate lighting throughout the day—brighter, cooler lights in morning hours and warmer, dimmer lights after sunset—can mimic natural patterns. These small adjustments yield profound benefits for sleep quality, mood, cognitive performance, and long-term health. Ready to reconnect with the rhythm of life your body was designed to follow?

Slides and audio can be found at www.thehealthedgepodcast.com
Essential Provision meals Ready to Eat (MREs) can be found at www.essentialprovisions.com

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Curious about natural alternatives to expensive GLP-1 medications like Ozempic? Dr. Mark Pettus unveils powerful nutritional strategies to boost your body's own GLP-1 production for improved metabolic health and sustainable weight management.

This eye-opening presentation dives into the fascinating relationship between your diet, gut microbiome, and GLP-1 production. Dr. Pettus, a kidney and integrative medicine specialist with 40 years of medical experience, explains how quality protein, healthy fats, fiber-rich foods, and even bitter-tasting ingredients can stimulate your natural GLP-1 pathways without prescription medications.

You'll discover why the timing of your meals and exposure to natural light dramatically impacts hormone production, and how simple lifestyle adjustments can synchronize your circadian rhythms for optimal metabolic health. Dr. Pettus challenges conventional nutritional wisdom with evidence-based perspectives on protein requirements, healthy fats, and the critical importance of preserving muscle mass during weight loss.

Whether you're currently taking GLP-1 medications and seeking complementary strategies, looking for natural alternatives, or simply interested in optimizing your metabolic health, this webinar provides practical, accessible approaches based on cutting-edge nutritional science. Learn how to work with your body's natural hormonal systems rather than bypassing them, potentially reducing your dependence on expensive pharmaceutical interventions while improving your overall health.

Take control of your metabolic health through these natural nutritional strategies to enhance your body's own GLP-1 production. Visit Dr. Pettus' website www.thehealthedgepodcast.com for the video and slide deck.

For amazing GLP-1 inducing meals ready to eat (MREs) from Essential provisions, go to: https://essentialprovisions.com/collections/meals-ready-to-eat-mre

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Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as "the cause of everything" and introduces the concept of "inflammaging" – how chronic inflammation accelerates biological aging and compromises quality of life.

Dr. Pettus takes us beyond conventional medical thinking to understand that while inflammation is an essential protective mechanism, it becomes destructive when chronically activated. Our modern environment, filled with processed foods, chronic stress, environmental toxins, and disrupted sleep patterns, keeps this system perpetually triggered, setting the stage for everything from diabetes to autoimmune conditions.

The most eye-opening revelations come when Dr. Pettis challenges popular nutritional dogma. He explains why fat has been unfairly vilified while highlighting how the standard American diet—dominated by processed carbohydrates and industrial seed oils—creates the perfect inflammatory storm. You'll discover why quality animal proteins and fats may be critical anti-inflammatory allies while learning how to identify truly nutritious foods that align with your biology.

Beyond nutrition, you'll gain practical insights into creating a comprehensive anti-inflammatory lifestyle through improved sleep, stress management, movement, and perhaps most surprisingly, through cultivating self-love and meaningful connections. Dr. Pettus shares specific testing recommendations to objectively measure your inflammation levels and track your progress.

Whether you're dealing with chronic health challenges, carrying extra weight, struggling with energy levels, or simply want to optimize your health span, this presentation offers a refreshing perspective that empowers you to address root causes rather than merely managing symptoms. Take the first step toward creating an anti-inflammatory lifestyle by implementing these evidence-based strategies today.

For video recording and slide deck go to www.thehealthedgepodcast.com

For Essential Provisions Nutritional Meals Ready to Eat (MREs) go to www.essentialprovisions.com

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Prepare to have your understanding of genetics completely transformed. The revolutionary science of epigenetics reveals that you're not simply a prisoner of your DNA – you're actively participating in how your genes express themselves through every choice you make.

Dr. Mark Pettus takes us on a fascinating journey through this emerging field that bridges the gap between fate and free will. Drawing on cutting-edge research and decades of clinical experience, he explains how our modern environment creates a profound mismatch with our ancient genetic template, setting the stage for chronic disease. The 21st century human faces challenges our ancestors never encountered – from ultra-processed foods to artificial lighting to environmental toxins – all triggering genetic expressions incompatible with optimal health.

The most empowering revelation? These expressions can change in real-time based on lifestyle choices. Within hours of consuming whole foods rather than processed ones, gene switches flip from promoting inflammation to reducing it. Regular movement, quality sleep, meaningful relationships, and even our thought patterns all influence our "book of life" at the molecular level. Dr. Pettis shares compelling research showing how maternal stress during pregnancy alters offspring epigenetics for decades, how indigenous populations saw 500% increases in diabetes within a generation after adopting Western lifestyles, and how we can potentially reverse our biological clocks through targeted lifestyle changes.

Discover why Blue Zone populations maintain extraordinary health into their 100s and how you can implement their wisdom into your modern life. This isn't just about preventing disease – it's about actively creating health by bringing your lifestyle into alignment with your evolutionary biology. The science is clear: you have far more control over your genetic expression than previously imagined. What will you write in your book of life?

Powerpoint slides and video can be found at www.thehealthedgepodcast,com

Essential Provisions whole foods meals ready to eat (MREs) at www.essentialprovisions.com

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Creatine might be the most underappreciated nutritional powerhouse in our health toolkit. While many associate it exclusively with weightlifters and athletes, the science reveals a molecule with profound benefits reaching far beyond the gym.

Mark Pettus MD and John Bagnulo PhD,MPH dive into creatine's fundamental role in human physiology as part of our body's most immediate energy production system – the ATP-PCR pathway. They unpack how this simple compound supports not just muscle strength and lean body mass, but potentially shields against age-related decline in both physical and cognitive function.

The conversation dismantles persistent myths around creatine safety, clarifying why concerns about kidney damage and steroid-like effects are scientifically unfounded. Both hosts share their personal experiences and professional insights about optimal dosing (3-5 grams daily), sourcing (creatine monohydrate remains the gold standard), and why dietary sources alone (mostly red meat and small fish) often fall short of providing optimal levels – especially as we age and our natural creatine synthesis declines.

Perhaps most fascinating is the emerging research around creatine's role in brain health. Lower brain creatine levels correlate with neurodegenerative conditions like Alzheimer's, Parkinson's and ALS, suggesting that maintaining adequate creatine stores might help protect against cognitive decline through multiple mechanisms – from basic energy provision to antioxidant effects and enhanced dopamine recovery.

Whether you're an athlete seeking performance gains, someone focused on healthy aging, or simply exploring evidence-based supplements with remarkable safety profiles, this episode offers valuable insights into why creatine deserves consideration as part of your daily health regimen. Listen now to understand how this simple molecule might be working silently to protect your most metabolically active tissues – muscle and brain – throughout your lifetime.

Research studies referenced can be found at https://www,thehealthedgepodcast.com

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Unlock the secrets to a healthier, longer life by mastering the science behind protein intake. Discover the critical role of animal protein in maintaining lean body mass, boosting metabolic health, and combating age-related muscle loss. We challenge traditional views and outdated guidelines, bringing you insights from recent research and experts in the field to help you reassess the power of protein in your diet.

With less than 10% of Americans achieving optimal metabolic health, it's time to rethink how much protein we really need. We explore groundbreaking studies by Dr. Luke von Loon and others that highlight the benefits of higher protein consumption for muscle synthesis, lasting well beyond 24 hours. By understanding how our ancestors thrived on protein-rich diets, you'll gain a new appreciation for why your body efficiently uses protein and how it can transform your health and physique.

Dive deeper into the specifics of protein optimization, as we discuss the ideal range of 1.2-1.6 g/kg/day for maintenance and up to 1.6 to 2+ grams per kilogram per day for anabolic muscle growth and strength. Learn about the superior amino acid profiles in animal proteins and the essential role of branched-chain amino acids and potassium. We also cover the benefits of creatine and how word-of-mouth communication can be a powerful tool for sharing these life-changing insights. Embrace a diet rich in animal protein and healthy fats, while cutting out sugars and processed carbs, to achieve a more vibrant, healthier you.

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In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition.

https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihub

https://www.thehealthedgepodcast.com