Episodios

  • Max Marchione, Founder of Superpower: 10x doctors, and why action beats perfection

    Max Marchione, Founder of Superpower: 10x doctors, and why action beats perfection
    Jan 9 2026
    #TheShot of #DigitalHealth 2026 episode almost didn’t happen - Jim Joyce was in the air, I was back in cold New Jersey, and Max was somewhere warm and productive (naturally). But missing it would’ve been a mistake. Max Marchione, founder of Superpower, joined me for a wide-ranging conversation on why modern healthcare is fundamentally broken - and why diagnostics, AI, data, and first-principles thinking might finally fix it. We talked about: - Growing up with chronic health issues no doctor could explain - Why “10x doctors” exist - and why most medicine can’t scale them - How AI will soon outperform humans at clinical reasoning - And what it actually takes to scale a healthcare startup without losing your soul This wasn’t a polished healthcare panel. It was a real conversation about truth, tradeoffs, and taking massive action - even when you know you’ll mess some of it up. If you’re building in health, longevity, AI, or just trying to feel better in your own body… this one’s worth your time.
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    34 m
  • Neil Dunwoody, COO of SPRYT : From Stand-Up Comedy to HealthTech & Fixing Healthcare Access using AI

    Neil Dunwoody, COO of SPRYT : From Stand-Up Comedy to HealthTech & Fixing Healthcare Access using AI
    Dec 18 2025
    What happens when a class clown from Monaghan builds one of the most quietly impactful healthtech companies in Europe - and then takes on the U.S. healthcare system? In this year-end episode of The Shot of Digital Health Therapy, we sat down with Neill Dunwoody 🇺🇦 (aka “Funwoody”), co-founder of SPRYT, to talk about resilience, rejection, healthcare absurdities, and why meeting patients where they already are matters more than building yet another app. From standing in a bin at school ➝ scaling talent at UnitedHealth Group ➝ pivoting a sports app into an AI-driven healthcare orchestration platform, Neil’s story is as honest as it is instructive. We cover no-shows, NHS, U.S. healthcare economics, founder health, Ukraine, and why humor might be one of the most underrated leadership traits. 🎧 Worth your time if you’re building, scaling, or questioning the system you’re trying to fix. Fun mentions as always: Rachel Francine, Shaun Dodimead,Optum, NHS, MediDrive, LLC 00:00 Holiday banter, community singing & year-end reflections 02:00 Meet Neil Dunwoody (“Funwoody”) 03:30 Growing up in Monaghan, sport & stand-up comedy 06:30 Humor, resilience, and rejection 08:00 Recruitment, HR, and learning to read people 15:00 Scaling talent at UnitedHealth / Optum 22:00 Blitzscaling, culture breaks & hiring mistakes 31:30 The birth of SPRYT: sports → healthcare pivot 36:00 NHS pilots, WhatsApp, and no-show economics 43:00 U.S. expansion & healthcare fragmentation 48:00 Orchestrating care beyond appointments 53:30 Ukraine, Tech Link Ukraine & purpose 56:00 Founder health, weight loss & personal reset 58:00 Closing advice to younger self
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    1 h y 1 m
  • Amy Cosler, SVP at Carrum: From Carrying the Bag to Transforming Employer Healthcare

    Amy Cosler, SVP at Carrum: From Carrying the Bag to Transforming Employer Healthcare
    Dec 11 2025
    On this episode of #TheShot of #DigitalHealth therapy, Jim Joyce and I finally sat down with Amy Cosler, a dynamic healthcare leader who rose from old-school hospital sales to driving transformation across Livongo -> Teladoc Health, Lyra Health, and now Carrum Health. Amy shares stories from her early days "carrying a bag" (if you know, you know), navigating to hospital basements with paper maps, transforming a 65-year-old public company, being part of Livongo’s IPO, and leading sales in the exploding employer benefits space. She opens up about resilience, family, leadership, and why kindness and grit are not mutually exclusive. This conversation delivers deep insights for founders, sales leaders, employer-benefit innovators, and anyone navigating the rapidly evolving healthcare economy. 📉 Employers demand real savings ⏱️ Buying cycles are compressing 💸 Utilization pricing opens doors 🤝 Culture drives adoption 🏥 Value-based care delivers impact Fun mentions as always: Jim Pursley, Glen Tullman, Sean McBride, David Ebersman and many more... 00:00 – Opening banter; year-end episodes; creative side projects 03:00 – Introducing guest Amy Cosler 04:00 – Early life: oldest of four, Illinois upbringing, healthcare family roots 05:30 – First job: carrying the bag for Medaflex; 4:00 AM training rides; selling skin-prep products 09:00 – Early sales journey; winning President’s Club; joining Baxter 11:00 – Intrapreneurial experience: building a startup inside Allegiance 13:00 – Cardinal Health acquisition; leadership influences 15:00 – Transformation at Landauer; building radiation monitoring + medical physics business 20:00 – Culture shock moving from startups to legacy healthcare 23:00 – Deep dive into early clinical sales environment (maps, suits, coffee, meetings) 27:00 – Divestiture, financial success, personal reset 28:00 – Meeting her husband; triathlons; writing the first version of her book 30:00 – Enter Livongo: shifting from hospitals to employer benefits 33:00 – Livongo culture, mission focus, member empathy 35:00 – Teladoc acquisition; overnight customer communications 38:00 – Pivot to Lyra; leading sales in mental health 39:30 – Joining Carrum; value-based care for surgery, cancer, SUD 41:00 – Employer trend challenges; cost inflation; need for bold solutions 45:00 – The misconception that kindness isn’t compatible with toughness 46:00 – Lessons for entrepreneurs selling to employers 49:00 – PEPM vs utilization-based pricing 51:00 – Looking ahead; entrepreneurial future; completing her book 52:00 – Jim’s narrative future-casting question 54:00 – Amy’s emotional answer: focus on family 55:00 – Closing and thank you
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    56 m
  • Brian Lin of Cellsor: The Future Smells Different - Building the First Living E-Nose

    Brian Lin of Cellsor: The Future Smells Different - Building the First Living E-Nose
    Nov 26 2025
    This week on #TheShot of #digitalHealth Therapy, Jim Joyce and I sat down with someone who might just change how we all understand… well, everything. Because when you think “future of health tech,” your brain probably doesn’t jump to noses in petri dishes. But maybe it should. We hosted Brian Lin, a Tufts researcher and a co-founder of Cellsor, who is literally growing living smell tissue to build the world’s first biological smell "camera". Yes - a "camera" for scent. Think RGB for odors… except instead of 3 channels, humans have 400, dogs have 700, elephants have 2,000, and Jim has… well, that’s still in peer review. 😅 Some highlights: 🧠 Humans have 400 smell receptors - meaning we “smell in 400 dimensions,” far beyond what we can verbally describe. 👃 Most people begin losing smell sensitivity in their 50s–70s without realizing it. 🛡️ The same tech could detect explosives, chemical threats, or hazardous compounds at checkpoint distance. 🔬 Brian’s company uses living tissue, not electronic sensors - truly an actual biological nose. 📡 The system aims to create the world’s first universal smell-recording “camera.” 💡 Future applications span diagnostics, food science, perfumery, defense, and everyday consumer tech. The science is wild, the implications are massive, and the conversation? Pure fun. 🎧 Give it a listen - and trust me, this one will stay with you in ways you can’t quite describe… because we don’t yet have the right vocabulary for smell. Fun mentions as always: Laura Hamilton Daniel Couchman Kendall #healthcare #digitalhealth #biotech #innovation #futureofwork #AI #sensorytech 00:00 – 02:10 Thanksgiving Banter & Show Opening Eugene and Jim share Thanksgiving plans, travel updates, and open the episode. 02:10 – 03:20 Scoop of Thanks Story A heartwarming story about cancer survivors bringing ice cream to oncology staff. 03:20 – 04:25 Introducing Brian Lin Jim recounts meeting Brian at Boston Startup Week over beer and ham sandwiches. 04:25 – 06:15 How Brian Meets People (The Whiskey Method) Brian explains his tradition of bringing whiskey to conferences to meet people. 06:15 – 07:45 Brian’s Background Growing up in Reading, Massachusetts; parents immigrating from China. 07:45 – 10:20 Childhood Pyro Stories Thermite experiments, accidental bed fires, and early science curiosity. 10:20 – 12:20 Education Path Undergrad at RPI, moving to Tufts for a PhD, meeting his wife. 12:20 – 15:00 From Cancer Lab to Smell Research Why cancer signaling wasn’t a fit and how he discovered the olfaction lab. 15:00 – 17:00 The Beer That Improves Dissections A lab story about shaky hands, a Corona with lime, and perfect dissections. 17:00 – 21:00 Understanding Smell Biology Why smell matters, how neurons regenerate, and why people lose smell with age. 21:00 – 24:00 COVID and Smell Loss How COVID reprograms smell neurons, parosmia, and Brian losing smell in Scotland. 24:00 – 28:00 Smell, Culture, Memory, and Diagnosis How smell connects to emotion, depression models, and historical healing. 28:00 – 32:00 Dogs Detect Cancer; Human Nose Complexity Why electronic noses fail and how humans actually smell in 400 dimensions. 32:00 – 35:00 Growing a Living Nose in a Dish Founding CellSaur and using real biological tissue instead of sensors. 35:00 – 38:20 Applications and the Smell Camera Concept Recording smells like RGB/hex codes and connecting to perception models. 38:20 – 41:10 Business Strategy for Smell Tech Three-step pathway: R&D tools, security/defense, and medical diagnostics. 41:10 – 45:00 Market Imagination Future possibilities like airport screening, drones, and household smell libraries. 45:00 – 47:00 Fundraising as a First-Time Founder Brian shares what it’s like shifting from academia into startup fundraising. 47:00 – 50:00 Final Question and Advice Jim gives a future scenario; Brian answers with “hold your conviction.”
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    51 m
  • Tim Wentworth, Retired CEO of Walgreens : From Parking Lots to Boardrooms - Leadership Lessons running multi billion dollar companies

    Tim Wentworth, Retired CEO of Walgreens : From Parking Lots to Boardrooms - Leadership Lessons running multi billion dollar companies
    Nov 20 2025
    On this 3d long-form edition of #TheShot of #DigitalHealth Therapy, Jim Joyce and I had the privilege of sitting down for an unforgettable deep dive with Tim Wentworth, the candid, thoughtful, fiercely grounded and recently retired CEO of Walgreens (previously CEO of Evernorth Health Services). Tim’s story reads like a masterclass in leadership and life itself - from sweeping parking lots in Rochester to leading global healthcare giants like Cigna’s Evernorth and Walgreens. Across nearly two hours (and honestly, we could’ve gone four), Tim brought raw honesty, wisdom, and humor to every story - from his early scholarship thanks to a teacher who believed in him, to leading multi-billion dollar companies but always defining what it means to lead with heart. This is not just a leadership interview - it’s a living case study in resilience, humility, and purpose. 🧠 Key Takeaways 🔥 From parking lots to the C-suite 🏢 The birth, growth, and controversy of PBMs 💊 Merck - Medco, and the spin-off that changed healthcare 💼 Crisis leadership 101 💰 Cigna, Evernorth, and the end of rebates? 🏪 Walgreens, reinvention, and going private 💡 The power of asking for help 🎯 Leadership as legacy Fun mentions as always: Shaine Borukhovich Jay Parkinson, MD, MPH Dr Jack Kreindler Roberto Ascione Mark Cuban Robert Pellegrini Glen Stettin, MD David Snow Kenny Klepper David Benshoof Klein Richard Lungen Frank Sheehy David Cordani Neal Sample Per Lofberg 00:00 — Cold open: Parking-lot beginnings & the teacher who changed Tim’s life 06:20 — Early career: Music industry, Pepsi, Mary Kay, discovering healthcare 13:40 — Joining Medco: First exposure to healthcare operations 21:10 — PBM history: Why PBMs exist, why pharma once owned them, and why that broke 31:55 — Merck → Medco spinout: Fixing the original conflict of interest 41:12 — Express Scripts: Crisis moments, lawsuits, leadership under fire 50:28 — Cigna acquisition: Building Evernorth and changing the role of services 01:02:00 — The “no more rebates” move: What it means and why it matters 01:15:45 — Why Tim came out of retirement to lead Walgreens 01:20:50 — Was he brought in to take Walgreens private? 01:29:30 — Running a 300,000-person company vs. running a PBM 01:38:40 — The future of community pharmacy & neighborhood care 01:46:10 — Startups, AI, and what founders keep getting wrong 01:54:50 — Leadership legacy & advice to his younger self
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    2 h y 6 m
  • Alette Hunt, Novartis - From Proteins to Practical AI

    Alette Hunt, Novartis - From Proteins to Practical AI
    Nov 5 2025
    On this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I had the pleasure of chatting with the globally minded and endlessly curious Alette Ramos Hunt, PhD, Global Director, Digital Innovation & AI for Drug Discovery at Novartis. From being a third culture kid (Danish dad, Filipino mom, born in Japan, raised in Hong Kong) to becoming one of the sharpest voices connecting biotech, digital health, and AI, Alette brings perspective that’s as international as it is insightful. We explored her fascinating path from studying proteins in Glasgow to driving AI innovation in pharma, and how she’s bridging the gap between molecules, humans, and machines. She reminded us that practical AI and game-changing AI both have a place - one makes us efficient, the other makes us dream bigger. It’s an episode filled with humility, humor, and yes.. human intelligence - proving that even in a world of algorithms, empathy still leads the way. Fun mentions as always: Chandana Fitzgerald Jeff Weness Milind Kamkolkar [00:00-02:00] Bloopers, sunshine, and background banter. [00:03-05:00] Alette’s third-culture upbringing — Japan, Hong Kong, Denmark. [00:05-07:00] Boarding school, biochemistry, and falling in love with proteins. [00:10-12:00] From academia to Pfizer — bringing science to life. [00:13-15:00] Leap to HealthXL — discovering digital health beyond the lab. [00:18-21:00] Entering Novartis — pre-ChatGPT AI strategy and innovation cycles. [00:22-25:00] Practical AI vs. game-changing AI — redefining productivity. [00:24-28:00] AI and drug discovery — startups, partnerships, and collaboration. [00:29-34:00] Lessons on open-minded leadership and partnering with purpose. [00:36-39:00] Jim’s classic closing story and Alette’s advice: Value your strengths, cherish your partners.
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    41 m
  • Jon Pearce, CEO of Masterlete: From Zipnosis to Masterlete: Redefining Resilience

    Jon Pearce, CEO of Masterlete: From Zipnosis to Masterlete: Redefining Resilience
    Oct 30 2025
    On episode #178 of #TheShot of #DigitalHealth Therapy, Jim Joyce and I had a blast chatting with Jonathan Pearce, the thoughtful and forward-looking CEO of Masterlete - and previously the co-founder and CEO of Zipnosis, the company that pioneered asynchronous telemedicine long before it was mainstream. From balancing athlete-grade performance with mental resilience to building a company that refuses to compromise between data and empathy, Jon brings his trademark blend of humility and precision. He also opened up about his own mental health journey, reminding us that resilience isn’t just a leadership skill - it’s a human one. It’s an episode that reminds us - even in a world of algorithms and wearables, the human spirit still defines the win. 🔹 Top 5 Key Takeaways 💻 Lessons from Zipnosis: how DTC missteps became powerful playbooks 🤖 AI enables personalization - not replacement 🔥 Burnout prevention is the next performance edge 📊 From wearables to wisdom: data needs translation 🎯 Leadership = clarity, curiosity, and constant iteration Fun mentions as always: Pat Sukhum John Brownlee 00:00–02:30 — Welcome & banter: from sports metaphors to startup scars02:31–07:00 — Jon’s journey: building Masterlete and learning from athlete ecosystems07:01–12:30 — Data + empathy: the dual pillars of sustainable coaching12:31–16:00 — AI’s promise (and limits) in personal performance16:01–20:00 — Burnout and resilience: redefining “peak” for long-term success20:01–25:00 — The role of digital health platforms in preventive care25:01–30:00 — Leadership lessons: clarity, curiosity, and iteration in practice30:01–34:00 — Future of athlete engagement and real-time feedback34:01–38:00 — Building human connection in scalable tech models38:01–End — Lightning round + advice to Jon’s younger self
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    42 m
  • Mike McSherry, CEO of Xealth: From Boost Mobile to Boosting Digital Health

    Mike McSherry, CEO of Xealth: From Boost Mobile to Boosting Digital Health
    Oct 8 2025
    On this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I had the pleasure of catching up with the one and only Mike McSherry, serial entrepreneur and CEO of Xealth, whose journey goes from quitting Microsoft in Australia to co-founding Boost Mobile, to building the infrastructure behind digital health prescriptions - and now joining forces with Samsung. We covered everything from startups, serendipity, and Surescripts, to what it means to be insanely curious (his words!) and to always find your foxhole friends. Oh, and there may have been a few humble-brags about being the guy who helped power billions of Android phones ad their keyboards. 🦾 🔹 Top 5 Key Takeaways 💡 Curiosity drives innovation - be “insanely curious” about everything. 📈 Luck favors persistence - serendipity comes from hard work. 🤝 Build with trust - surround yourself with “foxhole friends.” 🏥 Healthcare is hard - slow, bureaucratic, but worth transforming. 🌍 Samsung + Xealth - connecting home devices to health data. Fun mentions as always: HLTH USA Samsung Electronics UPMC Providence 📋 00:00 – 02:00 | Catching up with Jim & Eugene, Vegas talk, and welcoming Mike. 📋 02:00 – 06:00 | Mike’s journey from Microsoft to Australia’s biggest web dev company. 📋 06:00 – 09:00 | Lessons from being a “Navy brat” and world traveler. 📋 09:00 – 13:00 | Founding Boost Mobile and its wild telecom legacy. 📋 13:00 – 17:00 | From Nuance to Providence: the path into healthcare. 📋 17:00 – 22:00 | Building Xealth as the “Surescripts for digital health.” 📋 22:00 – 27:00 | Selling to providers and the hard reality of healthcare economics. 📋 27:00 – 33:00 | Integrating with Epic & Cerner: the friend-or-foe dance. 📋 33:00 – 41:00 | The Samsung acquisition story and its big vision for connected health. 📋 41:00 – 49:00 | The future of ambient healthcare and consent-driven data. 📋 49:00 – 52:00 | Mike’s advice: be curious, find your foxhole friends, stay humble.
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    53 m
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