Episodios

  • Trial of the Week: PROWESS-SHOCK

    Trial of the Week: PROWESS-SHOCK
    Jun 21 2024
    Trial of the Week: PROWESS-SHOCK Special Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita 03:30 – Background studies/Setting the scene 30:25 – PROWESS-SHOCK discussion/Where are we now Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012. To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions. Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    1 h
  • 2023 Year-In-Review Literature Review Series

    2023 Year-In-Review Literature Review Series
    Jun 6 2024
    Literature Review Series 2023 Year-In-Review Special Guests: Jacquelyn Crawford, PharmD @jacuronium Kathleen Hartman, PharmD @HartKate8 04:30 – Neurology 11:05 – Cardiology 18:50 – Cardiac Arrest 26:30 – Pulmonary 35:00 – Sepsis 44:05 – Endocrine/Renal 52:30 – Trauma 61:05 – Infectious Diseases Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    1 h y 15 m
  • Trial of the Week: Ketamine for EM Agitation

    Trial of the Week: Ketamine for EM Agitation
    May 30 2024
    Trial of the Week: Ketamine for EM Agitation Special Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021. We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    46 m
  • Sanford Guide Q&A

    Sanford Guide Q&A
    May 28 2024
    Sanford Guide Q&A Special Guest: Doug Black, PharmD 04:40 – Doug’s background/Sanford guide introduction 14:20 – Print v. digital guide/included content 34:35 – Tables/tools highlights 41:55 – Doug’s favorites/conclusions Sanford Guide Website: https://web.sanfordguide.com/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    1 h y 4 m
  • Code ICH

    Code ICH
    May 23 2024
    Code ICH Special Guest: Gabe Fontaine, PharmD, MBA, BCPS, BCCCP, FNCS, FCCM @gabe_fontaine 04:00 – Code ICH and history of ICU bundled care 15:15 – BP control 22:50 – Hemostasis 33:15 – Challenges & future directions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/code-ich-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    48 m
  • Trial of the Week: MENDS2

    Trial of the Week: MENDS2
    May 21 2024
    Trial of the Week: MENDS2 Special Guest: John Devlin, PharmD, BCCCP, MCCM, FCCP @devlinpharmd 03:20 – PADIS background and research introduction 35:25 – MENDS2 discussion John Devlin joins to review the May Trial of the Week “Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis” the MENDS2 study, published in NEJM in 2021. We set the scene by discussing how John developed an interest with PADIS research, discussing PK/PD sedative properties and considerations, landmark trials prior to MENDS2, and how much background work is required for a large RCT. Then we dive into the MENDS2 trial itself. Any significant findings? Biggest methodologic differences from MENDS2 and previous studies? Most challenging process of blinding? Any potential safety concerns? How to avoid unblinding study patients (and why that’s so important)? Plus, trial fun facts, seeing your name in a NEJM research article, applying MENDS2 findings into daily practice, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/mends2-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    1 h y 18 m
  • Rapid Reaction: ANNEXA-I

    Rapid Reaction: ANNEXA-I
    May 16 2024
    Rapid Reaction: ANNEXA-I 02:35 – Study design/results 18:30 – Considerations/questions Reference List: https://pharmacytodose.files.wordpress.com/2024/05/annexa-i-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    33 m
  • Trial of the Week: DESIRE & In-Flight Medical Emergencies

    Trial of the Week: DESIRE & In-Flight Medical Emergencies
    May 14 2024
    Trial of the Week: DESIRE & In-Flight Medical Emergencies References Special Guests: Jim Miller, PharmD, BCCCP @millerjtm Michael Liu, PharmD, MBA, BCCCP, BCNSP, BCPS 04:05 – DESIRE trial 31:15 – In-flight medical emergencies The episode starts off with special guest, Jim Miller, helping review the DESIRE study as a Trial of the Week. We set the scene reviewing dexmedetomidine pharmacokinetic advantages and landmark dexmedetomidine research. Then we highlight the DESIRE trial itself discussing the study methodology and results. What was considered usual care with regards to sedation? What is the external validity in this trial? What was the effect of changing the primary outcome measure mid-study? Are there anti-inflammatory properties with dexmedetomidine? What did Jim’s novel research show? What would Jim and I want for sedation if mechanically ventilated? And much more. Then the episode closes with Michael Liu highlighting his experience assisting with an in-flight medical emergency. We review his AJHP article describing his experience. Was this his first time in this situation? Biggest difference between in-hospital and out-of-hospital emergency response? What advice would he give others? And so much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/05/desire-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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    55 m