It's our 100th episode! Dr. Rukhsana Mirza sits down with Drs. Aleksandra V. Rachitskaya and Kevin C. Allan to discuss their retrospective study using the TriNetX network to investigate the risk of neovascular age-related macular degeneration (AMD) in patients taking glucagon-like peptide-1 receptor agonists (GLP-1RAs). From their Ophthalmology Retina article, "Glucagon-Like Peptide-1 Receptor Agonist Use and Risk of Neovascular Age-Related Macular Degeneration in a National Cohort Study."

Glucagon-Like Peptide-1 Receptor Agonist Use and Risk of Neovascular Age-Related Macular Degeneration in a National Cohort Study. Allan, Kevin C. et al. Ophthalmology Retina. In press

Sign up for the next Ophthalmology Journal Virtual Club on February 25, 2026, at https://store.aao.org/ophthalmology-virtual-journal-club.html

Dr. Edmund Tsui and author Dr. Douglas A. Jabs discuss the results of the ADVISE Trial, designed to compare adalimumab to conventional immunosuppressive drugs for the treatment of non-infectious intermediate, posterior, and panuveitides. From Dr. Jab's Ophthalmology article, "Adalimumab vs. Conventional Immunosuppression for Uveitis (ADVISE) Trial."

Adalimumab vs. Conventional Immunosuppression for Uveitis (ADVISE) Trial. Jabs, Douglas A. et al. Ophthalmology. In press.

Sign up for the next Ophthalmology Journal Virtual Club on February 25, 2026, at https://store.aao.org/ophthalmology-virtual-journal-club.html

Our newest host and Social Media Editor, Dr. Rukhsana Mirza, interviews Dr. Phoebe Lin. Together, they discuss Dr. Lin's study on whether an intestinal microbial signature is associated with advanced age-related macular degeneration and the relationship between the microbiota and AMD genetic risk. From her Ophthalmology Science article, "Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration."

Dr. Phoebe Lin is an editor for Ophthalmology Science.

Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration, Dadgar, Neda et al. Ophthalmology Science, Volume 6, Issue 1.

Dr. Emily Schehlein is joined by Dr. Cecilia S. Lee and Dr Parisa Taravati, authors of "Elevated Intraocular Pressure Immediately after Cataract Surgery and Future Risk of Primary Open-Angle Glaucoma in the IRIS® Registry (Intelligent Research in Sight)." Together they discuss the associations between postoperative intraocular pressure after cataract surgery and the future risk of developing primary open-angle glaucoma in patients without prior glaucoma, glaucoma suspect, or ocular hypertension diagnoses.

Elevated Intraocular Pressure Immediately after Cataract Surgery and Future Risk of Primary Open-Angle Glaucoma in the IRIS® Registry (Intelligent Research in Sight). Gim, Nayoon et al. Ophthalmology Science, Volume 5, Issue 6.

Dr. Edmund Tsui interviews Dr. Brian C. Toy on his retrospective cohort study which shows that oral doxycycline clinical and serologic outcomes are comparable to IV penicillin for syphilitic uveitis, published in Ophthalmology. From "Outpatient Oral Doxycycline versus Intravenous Penicillin for Syphilitic Uveitis."

Outpatient Oral Doxycycline versus Intravenous Penicillin for Syphilitic Uveitis. Bao, Yicheng K. et al. Ophthalmology, Volume 132, Issue 12, 1457 - 1459.

On September 5, 2025, the FDA issued a recall for the CorNeat EverPatch. Dr. Emily Schehlein is joined by Dr. Thomas V. Johnson to discuss his study on the early exposure and surgical revision rates of the CorNeat EverPatch. Later, Dr. Henry Jampel explains the difference between FDA clearance and FDA approval for medical devices.

Dr. Johnson coauthored the Ophthalmology article, "Early Postoperative Conjunctival Complications Leading to Exposure of Surgically Implanted CorNeat EverPatch Devices." Dr. Jampel cowrite the accompanying Commentary, "The CorNeat Everpatch and the Process of FDA Authorization."

Dr. Henry Jampel is an Associate Editor for Ophthalmology and the Editor-in-Chief for Ophthalmology Glaucoma. Dr. Thomas V. Johnson is an Associate Editor for Ophthalmology Science.

Early Postoperative Conjunctival Complications Leading to Exposure of Surgically Implanted CorNeat EverPatch Devices. Kanter, Jacob et al. Ophthalmology, Volume 132, Issue 7, 799 – 814.

The CorNeat Everpatch and the Process of FDA Authorization. Jampel, Risa; Jampel, Henry. Ophthalmology, Volume 132, Issue 7, 815 – 816.

The Academy's BCSC is your trusted source of clinical knowledge. The 2025-2026 edition includes a major revision to Section 8: External Disease and Cornea. Updates include a new interactive case study on Fuchs endothelial corneal dystrophy and cataracts, as well as 15 new videos of surgical procedures. Advance order Section 8 today at aao.org/BCSC.

Dr. Emily Schehlein sits down with author Dr. Nathan Congdon to break down the results of the GLAUrious Study on comparing automated, gonioscopy-free, noncontact, image-guided direct selective laser trabeculoplasty with conventional SLT in open-angle glaucoma and ocular hypertension to reduce intraocular pressure. From the Ophthalmology article, "Randomized Noninferiority Trial of Direct Selective Laser Trabeculoplasty in Open-Angle Glaucoma and Ocular Hypertension."

Randomized Noninferiority Trial of Direct Selective Laser Trabeculoplasty in Open-Angle Glaucoma and Ocular Hypertension. Gazzard, Gus; Traverso, Carlo Enrico; et al. Ophthalmology, Volume 132, Issue 10, 1091 – 1104.

Dr. Rajesh Rao discusses the risk factors for epiretinal membrane formation in patients with diabetes mellitus with Dr. Shinji Kakihara, first author of the Ophthalmology Science article, "Epiretinal Membrane Is Associated with Diabetic Retinopathy Severity and Cumulative Anti-VEGF Injections."

Epiretinal Membrane Is Associated with Diabetic Retinopathy Severity and Cumulative Anti-VEGF Injections. Kakihara, Shinji et al. Ophthalmology Science, Volume 5, Issue 3.

If you are unable to travel to AAO 2025, you can still enjoy the unparalleled program by registering for AAO 2025 Virtual. Get access to the annual meeting course and sessions recorded in Orlando, on-demand-only content specifically for the online platform, videos and posters, and CME credits. Learn more and register at aao.org/RegNow.

Ophthalmology journal events at AAO 2025:

· Peer Review Masterclass: A Practical Workshop for Journal Authors and Reviewers: Become a peer reviewer for the Academy's Ophthalmology journal, the leading journal in the field, and its companion journals, Ophthalmology Retina, Ophthalmology Glaucoma, and Ophthalmology Science. Dr. Emily Schehlein and Dr. Aaki Shukla, highly experienced reviewers and authors for various journals, will lead this free interactive workshop. Sponsored by Elsevier.

· The Year in Literature: Editor's Choice Highlights From the Ophthalmology Journal Family: Join Ophthalmology's Editor-in-Chief, Dr. Russell Van Gelder, as he presents the top Ophthalmology articles on Sunday October 19 at 9:45am. Search "SYM31" in the Mobile Meeting Guide for more information.

· Meet the Editor: Join us for an intimate conversation with Ophthalmology Editor-in-Chief, Dr. Russ Van Gelder, during the American Academy of Ophthalmology Annual Meeting. This special meet and greet offers ophthalmologists, residents, and researchers a unique chance to connect directly with one of our field's most influential editorial voices. Sunday, October 19, 3:30-4:30 pm, Academy Hub at the exhibit hall.