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Eli Lilly's phase 2 SYNERGY-NASH study shows tirzepatide effectively resolves MASH and improves fibrosis, offering hope for millions. Read more here: https://www.onthepen.com/post/tirzepatide-shows-promise-in-treating-mash-key-findings-from-the-synergy-nash-study

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Ro.co/supply-tracker

FDA shortage update (tiktok video):
Link:https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

EASL (European Association for the Study of the Liver) 2024 in Milan Italy
Link: https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
Link: https://www.biospace.com/article/mash-clash-between-lilly-and-boehringer-zealand-takes-center-stage-at-easl24/

Walgreen:
Link: https://www.benefitspro.com/2024/06/03/walgreens-will-conduct-clinical-trials-for-boehringer-ingelheims-new-obesity-drug/?slreturn=20240610103336

Kroger (tiktok video):
Link: https://www.aol.com/news/kroger-health-revamps-weight-management-132122808.html

Eli Lilly Clinical trial:
Link: https://clinicaltrials.gov/study/NCT06373146?term=tirzepatide&aggFilters=status:act%20rec&rank=6

Eli Lilly CFO:
Link: https://www.prnewswire.com/news-releases/lilly-announces-departure-of-anat-ashkenazi-chief-financial-officer-302163882.html

China:
Link: https://www.benzinga.com/news/24/06/391975

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https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k

Novo Nordisk Advertising:

• Novo Nordisk launches new advertising campaign "The Power of Wegovy"
• This advertisement includes the new indication for reduction of cardiovascular risk
• For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million. The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic went to online video platforms (i.e. social media like youtube)
• Link: https://www.youtube.com/watch?v=dhretLXYkZ4

Structure Therapeutics GSBR-1290

• GSBR-1290 is a small molecule GLP-1 pill
• In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
• At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
• Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
• Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure

Elon musk tweet:

• Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
• This tweet has currently been seen 325,500 times

Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy

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Zachariah Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health, he joins #OnThePen to talk all things #mounjaro #zepbound #wegovy #ozempic

Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health.

https://ro.co/weight-loss/supply-tracker/

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SHOW NOTES:
Ozempic study in New England Journal of Medicine:
Link: https://www.bloomberg.com/news/articles/2024-05-24/novo-s-ozempic-slashes-risk-of-death-in-kidney-disease-study

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In this week’s episode of On The Pen Live, guest Scott Liberto of PlanetScott.com joins to discuss his experience in the Survodutide clinical trial.

Survodutide is an investigational dual agonist targeting both the glucagon and GLP-1 receptors, developed by Boehringer Ingelheim in collaboration with Zealand Pharma. This novel drug is designed to treat obesity and metabolic dysfunction-associated steatohepatitis (MASH).

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📰 SEEKING ALPHA ARTICLE: https://seekingalpha.com/news/4092598-tiktok-restrict-weight-loss-drug-promotion

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SHOW LINKS:
Novo Nordisk fire:
Link: https://www.wsj.com/livecoverage/stock-market-today-dow-jones-earnings-05-16-2024/card/fire-at-novo-nordisk-construction-site-gives-investors-a-scare-eSSAtdDDhxYwUw3bGDZI?mod=lctimeline_finance

New CagriSema drug trial
Link: https://clinicaltrials.gov/study/NCT06409130

Wegovy Heart Benefits:
Link: https://www.cnn.com/2024/05/13/health/wegovy-trial-analysis/index.html

CT-488 Phase 1 Results:
Link:

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Hello Fresh Free Box:
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SHOW NOTES:
Update on Bernie Sander's fight against high prices for GLP-1 medicationsLink: https://www.msn.com/en-us/health/other/novo-asks-for-more-time-to-answer-sanders-on-ozempic-s-price/ar-BB1lZ0P2

CFO of Viking Therapeutics sold stock
Link: https://www.investing.conews/company-news/viking-therapeutics-cfo-sells-over-49-million-in-company-stock-93CH-3419573

Novo Nordisk bond sale (Bloomberg article):
Link: https://www.bloomberg.com/news/articles/2024-05-13/ozempic-maker-novo-nordisk-plans-bond-sale-to-fund-expansion?embedded-checkou

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