Living with myeloma means facing decisions at different points in the journey. One of the biggest moments is the first relapse—when the disease returns after initial treatment.

The good news is that treatment options at first relapse are better and more personalized than ever. One of the most promising is CAR T-cell therapy, which geneticallyengineers a person’s own immune cells to target and destroy myeloma cells. For many patients, it offers the possibility of a deep response, time off therapy, and a chance to regain a sense of normalcy.

In this episode, we’ll explore what receiving CAR T-cell therapy after first relapse looks like—who may be a good candidate, how the process works, what thebenefits and risks are, and what the experience is like for clinicians, patients, and caregivers.

Topics of discussion:

(01:49) When does CAR Tbecome something a patient might hear about?

(03:20) Who may be a goodcandidate

(09:15) How the processworks

(13:39) What theexperience is like for clinicians, patients, and caregivers

This episode is supported by AbbVie, Amgen, Bristol Myers Squibb, Genentech, Johnson & Johnson, Legend Biotech, Pfizer, Regeneron, and Sanofi.

To learn more, download the A Guideto CAR T-Cell Therapy in Myeloma Fast Facts in Myeloma sheet here.

To learn more about multiple myeloma, visit www.themmrf.org.

If you want to learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

Hearing the words “you have multiple myeloma” can be shocking and confusing—learning about the disease and finding the right care team are the most important stepsyou can take after your diagnosis. This episode discusses the importance of seeing a myeloma specialist at a center that treats a high volume of myeloma patients and has an active research program. Newly diagnosed patients, with support from a caregiver, should advocate for themselves by staying informed, asking questions, seeking second opinions if needed, and using credible resources to stay up to date on advances in care.

Topics of discussion:

(04:04) First step after a myeloma diagnosis

(09:36) Caregiver support to help with information overload

(12:31) Finding a myeloma specialist

(19:20) Resources and information

This episode is supported by AbbVie, Amgen, Bristol Myers Squibb, Genentech, Johnson & Johnson, Legend Biotech, Pfizer, Regeneron, and Sanofi.

To learn more about newly diagnosed multiple myeloma, download the Newly Diagnosed Multiple Myeloma booklet here.

To learn more about multiple myeloma, visit ww.themmrf.org.If you want to learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

In part 2, we get practical: planning treatment around family calendars and holidays, deciding between inpatient and outpatient treatment, arranging travel and temporary housing, syncing records between centers, getting financialassistance, and advocating for yourself. With insights from Dr. Joshua Dower (Stamford Health) and lived experiences from myeloma patients Kim and Annie, this episode is your playbook for navigating the details.

Topics of discussion:

(01:13) Navigating travel and scheduling for CAR T-cell therapy

(06:02) Navigating travel and scheduling for bispecific antibody therapy

(09:25) Support from the care team

(11:23) Advocating for the best possible care during transition of care

This episode is supported by Pfizer Inc.

To learn more about bispecific antibody and CAR T-cell therapy, download the Immunotherapy booklet here.

To learn more about multiple myeloma, visit themmrf.org.

To learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

Part 1 of this two-part Myeloma Matters episode focuses on introducing the concept of transition of care for myeloma patients: how treatment often begins at specialized centers and then shifts to local providers. Dr. Joshua Dower of Stamford Health explains why CAR T and bispecific therapies typically start at specialty centers, how care teams coordinate, and what early co-management betweenacademic and local doctors looks like. Myeloma patients Kim and Annie discuss their experiences with navigating this transition. This episode also touches on finding myeloma specialists, building trust with care teams, and the rolecaregivers fill in the early treatment phases.

Topics of discussion:

(01:51) Why treatment often starts at academic or specialized cancer centers

(03:40) Choosing bispecific antibody or CAR T-cell therapy

(05:54) Finding a myeloma specialist

(11:48) The path from specialized center to local care

(14:24) Caregiver roles

(18:04) Final thoughts

This episode is supported by Pfizer Inc.

To learn more about bispecific antibody and CAR T-cell therapy, download the Immunotherapy booklet here.

To learn more about multiple myeloma, visit themmrf.org.

To learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

In this episode, we explore an exciting and rapidly evolving area of myeloma treatment: immunotherapy, with a focus on two groundbreaking approaches, CAR T-cell therapy and bispecific antibody therapy. These therapies are changing myeloma care, offering new hope for patients whose treatment no longer works. You’ll hear about the decisions they faced when considering these treatments; the ways they prepared mentally, physically, and emotionally; and what their experience has been.

Topics of discussion:

(4:05) Decision-making process for CAR T-cell therapy

(8:15) Experience receiving CAR T-cell therapy

(12:35) Experience receiving bispecific antibody therapy

(14:58) Considerations for enrolling in a clinical trial

(20:15) Role of caregivers and patient advocates

(24:05 Managing side effects

(33:18) Impact of CAR T-cell and bispecific antibody therapy

This episode is supported by AbbVie, Amgen, CURE, Genentech, GSK, Johnson & Johnson, Karyopharm, Legend Biotech, Pfizer, Regeneron, and Sanofi.

To learn more about CAR T-cell therapy, download A Guide to CAR T-Cell Therapy in Myeloma here.

To learn more about bispecific antibody therapy, download Bispecific Antibodies for Multiple Myeloma: What you Need to Know here.

To learn more about multiple myeloma, visit www.themmrf.org.

If you want to learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

In this episode, we discuss supportive care, which encompasses the management of both treatment side effects and complications of multiple myeloma rather than the disease itself. We’ll hear from a patient living with myeloma and a social worker working in oncology as they discuss their experiences with supportive care and what you can do to improve your quality of life.

Topics of discussion:

(4:54) Supportive care and quality of life

(7:26) Role of a social worker

(9:06) Fatigue

(13:31) Pain

(19:44) Peripheral neuropathy

(21:56) Mental health distress

(27:42) Gastrointestinal symptoms

(31:08) How to communicate with your health care team

This episode is supported by AbbVie, Amgen, CURE, Genentech, GSK, Johnson & Johnson, Karyopharm, Legend Biotech, Pfizer, Regeneron, and Sanofi.

To learn more about supportive care, visit www.themmrf.org/support.

To learn more about multiple myeloma, visit www.themmrf.org.

If you want to learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

In this episode, you’ll learn what being a cancer survivor means, why the concept of survivorship is important to patients living with myeloma, how to be an empowered advocate for your care, and what to expect day-to-day in your myeloma journey.

MMRF patient navigators Erin Mensching, Grace Allison, and Brittany Hartmann join the podcast to provide up-to-date information on myeloma management, talk about resources that are available to myeloma patients, and offer suggestions on connecting with other myeloma patients, caregivers, and experts.

(0:00) Definition of survivorship

(2:04) Learning the diagnosis

(10:24) Shared decision-making

(39:28) Empowerment through knowledge

This episode is supported by AbbVie, Adaptive, BMS, CURE, Genentech, Kite/Arcellx, Pfizer, Regeneron, and Sanofi.

To learn more about newly diagnosed multiple myeloma, download the Survivorship Fast Facts in Myeloma here.

To learn more about multiple myeloma, visit www.themmrf.org.

If you want to learn more about the MMRF’s FREE resources for patients and caregivers, visit the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.

In this episode of Myeloma Matters, you’ll learn about autologous stem cell transplantation and why it is considered the standard of care for eligible newly diagnosed patients. You’ll hear from four patients who have undergone the procedure—sometimes even twice.

Topics of discussion:

(22:45) Stem cell transplantation as a treatment option

(28:30) What type of support is needed before and after a transplant?

(40:05) Potential long-term complications from a transplant

(43:40) Fertility issues when diagnosed at a young age

(45:24) Potential concerns when considering a transplant

(50:15) Concerns about the risk of secondary cancers from maintenance therapy

(57:57) Advice to those considering a transplant

(1:07:04) Can a transplant be saved for relapse?

This episode is supported by Adaptive, Amgen, Bristol Myers Squibb, GSK, and Janssen.

To learn more about autologous stem cell transplantation, download the Multiple Myeloma: Autologous Stem Cell Transplantation information sheet here.

To learn more about multiple myeloma, visit www.themmrf.org.

Stay up to date on the MMRF’s FREE programs and resources at the MMRF Education Hub.

If you have additional questions, call our MMRF Patient Navigation Center at 1-888-841- 6673.