In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain.

They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier.

The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions.

Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health.

Learn more about Dr. Julie Andersen and the Buck Institute:

https://www.buckinstitute.org/lab/andersen-lab/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

In this conversation, Professor S. Jay Olshansky discusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of biomarkers in predicting longevity, the societal implications of an aging population, and the ethical considerations surrounding advancements in longevity science.

Learn more about Professor S. Jay Olshansky:

http://sjayolshansky.com/sjo/Background.html

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutraceuticals and therapeutic plasma exchange. The discussion also touches on the future of aging research, emphasizing personalized approaches and the democratization of diagnostics.

Learn more about Dr. David Furman:

https://www.buckinstitute.org/lab/furman-lab/

In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life.

She explains how this process is crucial for cognitive function and how it declines with age.

The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process.

Dr. Walker also explores the implications of her research for cognitive health, particularly in the context of neurodegenerative diseases, and the potential therapeutic strategies that could arise from understanding neurogenesis better.

Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it.

In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity, how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype reveals about your ideal sleep patterns.

From the effects of sleep deprivation on metabolism and aging to natural sleep tips, supplements, and cutting-edge alternatives to CPAP machines for sleep apnea, this conversation is packed with actionable advice to boost your sleep quality and your longevity.

Learn more about the Sleep Doctor, Dr. Michael Breus: https://sleepdoctor.com/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

What if targeting a single cellular pathway could slow aging and boost immunity?

Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity.

Learn more about Dr. Joan Mannick:

https://www.linkedin.com/in/joan-mannick-8089a614/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/