In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic.

As these systems degrade with age, misfolded proteins accumulate, cellular signaling falters, and vulnerability to neurodegeneration increases.

The discussion centers on why protein folding begins during translation, how molecular chaperones like TRIC preserve cellular integrity, and why aging creates a self-reinforcing cycle of proteostatic failure.

We also examine upstream mechanisms—and what restoring proteostasis could mean for future longevity interventions, healthspan preservation, and disease prevention.

Watch the full episode to understand why protein folding may be one of the most underappreciated levers in aging biology.

Over the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a chance to look back at some of the more interesting conversations we had on Longevity Roadmap in 2025.

Looking ahead, there's no sign that the pace is slowing. In longevity, it often feels like every year brings another set of breakthroughs, and 2026 is shaping up to be a big one. One of the most important trends to watch is the increasing role of artificial intelligence in medicine, particularly in pharmaceuticals. AI-driven, network-based drug repurposing efforts are starting to identify compounds that may influence aging biology and move more efficiently toward clinically relevant interventions. By the end of 2026, it's reasonable to expect early readouts or expanded trials that begin to meaningfully target the hallmarks of aging.

Before wrapping up this year, I just want to say thanks to everyone who's been listening this year. Your interest, your feedback, and your willingness to think critically about this space are what make the show worth doing.

See you in 2026!

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

Aging is usually linked to size, metabolism, and inevitable decline—but bats defy all three.

In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are rewriting the rules of longevity science.

The discussion explores how bats live far longer than expected for their size while avoiding cancer, immune dysfunction, and chronic inflammation. They examine how stable telomeres, enhanced DNA repair, and tightly controlled immune responses allow bats to age slowly despite extreme metabolic demands.

Watch the full episode to understand why bat biology is reshaping how researchers think about human aging and healthspan.

Learn more about Dr. Emma Teeling:

https://people.ucd.ie/emma.teeling

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com