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Be honest—have you ever rescued a French fry from the floor? In this bite-size myth episode, I test the famous “5-second rule.” I walk through what actually transfers to your food (fast), when that matters, and why a little microbial exposure isn’t always the villain—while drawing a hard line for high-risk settings and situations.

Key Topics & Takeaways

• The verdict meter: The 5-second rule is false—bacteria can transfer in <1 second. In a Rutgers lab study, juicy foods like watermelon picked up the most, gummies the least; tile/steel transferred more than carpet (Applied and Environmental Microbiology / PubMed
  ).
• Foodborne illness is common: ~48M illnesses/year in the U.S., ~128k hospitalizations, ~3k deaths. Usual suspects include Salmonella, E. coli, Campylobacter, Listeria, and norovirus. Symptoms are typically GI, but severe cases occur—especially in the very young, elderly, pregnant, or immunocompromised (CDC overview
  ).
• Context matters: Moisture and surface trump “time.” High-moisture foods collect more microbes; visibly dirty or high-traffic floors (think convenience stores) raise risk—regardless of seconds.
• When to skip the floor food—no debate: If you’re immunocompromised, pregnant, very young/elderly, or you’re in a hospital/clinical setting, don’t eat it. Full stop.
• Nuance: Are microbes always bad? Early, diverse exposure to benign environmental microbes associates with more resilient immunity. Farm-exposed kids had lower asthma/atopy rates (≈20–40%) versus city peers (NEJM
  ). Greening urban daycare yards (adding soil/plant matter) increased skin/gut microbial diversity and shifted immune markers in a favorable direction (Science Advances
  ). This doesn’t mean “eat off the floor”—it means the bigger story is about exposure diversity and context.
• My practice: At home, I don’t stress over a quick drop on a clean surface; out in public or medical settings, I pass.

Bottom Line
Microbes hop on fast; the “rule” doesn’t save you. But danger depends on what fell, where, and who is eating it. Be smart, especially if you or your environment are higher risk.

Call to Action
What health saying should I myth-test next? Text me your favorites (include your email so I can reply), and please rate the show on Apple/Spotify. Want my newsletter on practical, science-backed longevity? Join me at DrBobbyLiveLongAndWell.com.

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Summary: I unpack why medicine sometimes reverses course—and how you can tell sound evidence from shiny anecdotes—with physician-author Dr. Adam Cifu of the University of Chicago and co-author of Ending Medical Reversal
.

Key topics & takeaways

• Why medicine “flips”: Plausible theories + observational data → premature guidelines; true answers require randomized trials. Classic examples: menopausal hormone therapy, early peanut avoidance, and stents for stable angina (LEAP trial
  , COURAGE
  
  
• Open-minded skepticism: Ask, “What’s the human outcomes evidence?” Cool mechanisms and moving testimonials aren’t proof.
• Hype outside the clinic: Mitochondria “rechargers,” microbiome panaceas, and biological age tests are intriguing—but not ready for prime time.
• Nutrition sanity: For supplement evidence summaries, I like Examine
  .
• When AI helps (and when it doesn’t): Tools can orient you to established topics; they’re weaker on breaking studies. Look for linked primary sources.
• N-of-1 experiments: When evidence is uncertain and the outcome is measurable (sleep, blood pressure, pain), test on yourself—track a baseline, try the change, measure again, and, if possible, stop-start to confirm. Use symptom diaries, validated scales, or wearables.
• Humility is a signal: Trust sources that sometimes conclude “we don’t know.” I often check Cochrane Reviews
  for balanced syntheses.

About my guest
Adam Cifu, MD is a professor of medicine at the University of Chicago, author of 140+ peer-reviewed papers, and co-author of Ending Medical Reversal. He writes at Sensible Medicine.

Call to action
If this episode helped you think more clearly about health claims, share it with a friend and leave a quick review on Apple or Spotify. For my newsletter on practical, evidence-supported longevity, visit DrBobbyLiveLongAndWell.com
.

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I unpack what “ultra-processed” really means, why these foods are so easy to overeat, what the best evidence shows (including metabolic-ward studies), and how I personally navigate them without fear or perfectionism.

Key topics & evidence (in plain English):

• What counts as “ultra-processed”? I walk through the NOVA system—useful, not perfect—and where borderline items (frozen meals, boxed mixes) fit. See an overview of NOVA classifications here
  .
• How we got here: post-WWII abundance of refined flour, cheap sugars, oils, and a cultural push for convenience—now ~60% of the U.S. diet comes from UPFs (study
  ).
• Additives: stabilizers, emulsifiers, preservatives, and colors are generally recognized as safe (GRAS). I explain why, on their own, they’re probably not the main health issue.
• The bigger problem: UPFs are energy-dense, engineered for bliss (fat/sugar/salt + perfect texture), and easy to eat quickly—driving higher calorie intake.
  • Metabolic-ward crossover trial: +~508 kcal/day when participants ate UPFs vs minimally processed (Cell 2019
  ).
  • Overweight adults in a crossover design: +~814 kcal/day on the UPF week (PubMed
  ).
  • Another recent crossover RCT reports ~300 kcal/day higher on UPFs (Nature Medicine 2025
  ).

What I recommend (and what I do):

• Prioritize whole foods most of the time; shop the perimeter; cook when you can. Canned tomatoes/beans and frozen fruits/peas are fine helpers.
• If weight, diabetes, or blood pressure are concerns, be extra cautious with UPFs—they’re designed to be irresistible and calorie-dense.
• Moderation wins: I enjoy favorites (yes, even boxed mac ’n’ cheese and crunchy peanut butter) without letting them dominate my plate.

Takeaways you can use today:

1. Build meals around minimally processed proteins, veggies, fruits, and beans; let convenience items support—not star—in your diet.
2. Watch “calorie-dense + easy to overeat” combos (chips, sweets, fast food). If you have them, portion once, then put the package away.
3. If symptoms or inflammation are puzzling you, try a short UPF-light experiment (2–4 weeks) and see how you feel.

If this episode helped, please follow and leave a quick review—and share it with a friend who’s curious about UPFs. For my newsletter and resources, visit drbobbylivelongandwell.com.

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Cancer is the second leading cause of death, and while it sparks fear for good reason, 40% of cases are preventable. In this episode, I outline six practical, evidence-based steps that can help reduce your risk.

We begin by understanding which cancers are most common based on gender—breast, colon, and lung in women; prostate, colon, and lung in men. While some rare cancers (like pancreatic or ovarian) evoke greater fear, the focus here is on the ones we’re more likely to face and can meaningfully act on.

Next, I break down risk factors into two categories. Some are unavoidable—your sex, age, or family history. For example, if a close relative had breast or colon cancer, early screening or genetic testing may be warranted. However, only about 5–10% of cancers are directly linked to inherited genetic mutations (American Cancer Society
).

The more empowering list? Avoidable risk factors—where our actions matter most. Smoking remains the leading modifiable cause of cancer, responsible for about 19% of all cases. Excess weight and obesity account for another 8% and are especially tied to hard-to-treat cancers like pancreatic and ovarian (ScienceDirect
) and PubMed
). Visceral fat appears more predictive than BMI alone. Alcohol, especially in large quantities, is also linked to liver, GI, and breast cancers.

Some risks are cancer-specific. HPV causes nearly all cervical cancers, and melanoma is largely driven by UV exposure. Air pollution, especially particulate matter, may slightly increase lung cancer risk (ASCO Global Oncology
).

Step three is to act on what you can. Quit smoking, aim for a healthy weight, wear sun protection, and ensure your kids get their routine HPV and Hepatitis B vaccines
. Exercise plays a major role too—high activity levels correlate with 10–20% lower risk of several major cancers (JAMA
). In colon cancer survivors, regular exercise reduced recurrence by 30% (PubMed
).

Step four is awareness: don’t ignore new symptoms like unexplained bleeding or lumps. Early detection can be life-saving.

Step five is screening. If you're 45 or older, colonoscopy is now recommended. Women should get regular mammograms and PAP smears, and individuals with smoking history may benefit from lung CT scans. For rarer cancers with family history, targeted screenings may apply. I also address why whole-body MRIs
and liquid biopsies
aren’t ready for routine use.

Step six? Don’t put your hope in supplements. Large trials show omega-3s, vitamin D, beta carotene, and vitamin C offer no real protective benefit (NEJM VITAL Study
, Meta-analysis on Vitamin C
, JNCI on aspirin
).

Takeaways:
You can reduce your cancer risk by modifying lifestyle factors like smoking, weight, and activity. Don’t delay screenings—they catch cancers early when treatment is most effective. And remember: no supplement replaces proven preventive strategies.

Visit drbobbylivelongandwell.com
for more evidence-based tools, and listen to the full episode for actionable steps to help you live long and well.

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Can a positive mindset truly improve your health—or even help you beat disease? In this episode, Dr. Bobby and guest Sean McDevitt explore the evidence behind optimism, visualization, and prayer to uncover what really works.

In today’s episode of Live Long and Well, Dr. Bobby is joined by fitness and life coach Sean McDevitt to explore whether positive thinking can influence health outcomes. They dive into both anecdotal and clinical evidence, starting with sports psychology and then navigating the science behind mindset and disease.

The conversation opens with laughter and smiles—literally. Inspired by Norman Cousins’ Anatomy of an Illness, Dr. Bobby references a meta-analysis showing genuine smiling does, in fact, temporarily boost happiness, while artificial smiling (like holding a pen in your mouth) doesn’t.

They begin with sports, where 86 studies show that visualizing athletic success can improve performance in agility, strength, and game-specific skills. Next, they ask a deeper question: does having a positive attitude affect the progression of serious disease?

A meta-analysis of 26 studies on life satisfaction and longevity suggests happy people may live longer—especially when it comes to heart health. Optimism, for instance, was linked to a 35% reduction in cardiovascular events and a 15% decrease in all-cause mortality.

However, when it comes to cancer, the picture gets murkier. A review of 165 studies links stress to poorer survival, but a separate meta-analysis on coping styles found no consistent impact on recurrence or survival. One influential study on breast cancer patients even found that while helplessness predicted worse outcomes, having a “fighting spirit” made no significant difference (source). As Dr. Bobby notes, it’s important not to burden patients with guilt if they can’t “stay positive.”

The critical question becomes: if you're not naturally optimistic, can you cultivate positivity—and will it help? Encouragingly, several intervention studies suggest it might. One trial showed cardiac markers improved after optimism training, and a meta-analysis of 56 RCTs found a 15% boost in immune function after psychological interventions. A small MS study linked mindfulness to better walking ability, and a large RCT on breast cancer showed a 45% drop in recurrence with stress-reduction and mood-enhancing strategies.

Finally, the episode touches on spirituality. While many find comfort in prayer, evidence from an RCT of 800 ICU patients and a [meta-analysis] shows no significant impac

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In this deeply personal episode, Dr. Bobby reflects on his wife's cancer diagnosis and shares eight powerful lessons for anyone navigating the uncertainty of a serious illness. With insights from Dr. Helen Eshed, a board-certified gynecologic oncologist and Gail’s treating physician, this conversation blends personal experience with expert guidance to help you feel more prepared, empowered, and informed—whether for yourself or someone you love.

Together, they discuss when and why to seek a second opinion, including the importance of trusting your gut and asking your doctor how frequently they handle cases like yours. Dr. Bobby emphasizes the importance of finding a quarterback—a single provider who can oversee and coordinate all aspects of care, a role often filled by the medical oncologist or, in fortunate cases like Gail’s, by a specialist like Dr. Eshed who guides every step of the journey. They explore the nuanced role of the primary care physician, who may not lead cancer care but is critical in managing other chronic conditions and general health during treatment.

Dr. Bobby and Dr. Eshed also confront the flood of non-evidence-based treatments patients often encounter. Supplements, restrictive diets, and alternative therapies may be well-intentioned, but many lack credible evidence and can even interfere with medical treatments. Dr. Eshed underscores the importance of open communication with your doctor to discern helpful integrative therapies—such as acupuncture or massage—from those that may be harmful. If you’re unsure, bring it to your physician and evaluate together.

Another theme they unpack is the human need for agency during illness. Dr. Bobby highlights a randomized controlled trial in colon cancer survivors showing that a structured exercise program led to a 28% improvement in recurrence-free survival over eight years. This suggests that lifestyle changes like physical activity can make a real difference, even after diagnosis. But as he cautions, not everything promising on the internet is supported by research—so choose wisely and stay grounded in science.

They also touch on the emotional and spiritual dimensions of illness. From the rollercoaster of diagnoses to unexpected rituals like a gratitude ceremony for Gail’s uterus, Dr. Bobby emphasizes the value of community, spiritual support, and patient-centered rituals that help bring meaning to the process. Resources like survivorship counseling and disease-specific nonprofits can offer both information and connection during the journey.

Finally, they discuss the often-overlooked financial impact of serious illness. With treatments like surgery and immunotherapy costing thousands—even hundreds of thousands—of dollars, Dr. Bobby encourages listeners to proactively ask about costs, insurance coverage, and out-of-pocket maximums to avoid being blindsided.

Takeaways:

1. Ask the right questions early—about your diagnosis, treatment options, prognosis, and whether your doctor has experience with your specific condition.
2. Look for credible, evidence-based interventions that support your care rather than distract from it—especially when you're tempted to chase internet cures.
3. Build a strong, multi-layered support system—medical, emotional, spiritual, and financial—to help you weather the journey ahead with resilience and clarity.

Visit drbobbylivelongandwell.com
to sign up for his free October 2nd workshop on how to focus your energy on the habits that truly improve health and longevity—without making it your full-time job.

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Join my first live wellness workshop on October 2 at 6 PM CT, where we’ll tackle the question: Does Health Need to be a Full-time Job? It's free. Sign up here.

Can the type of food you eat influence how much you eat? In this episode, I explore how calorie density, texture, protein content, hydration, and even your perception of food can all affect fullness—and how understanding these levers can help you better manage your weight without feeling deprived.

We start by revisiting the foundational idea that maintaining a healthy weight impacts your risk of heart disease, diabetes, and cancer. While previous episodes discussed eating slowly and using smaller plates, today’s focus is on how the specific foods you choose can directly affect how much you consume.

Drawing from both personal anecdotes—like my wife Gail’s success with a no-flour, no-sugar approach—and recent science, I explore five key factors. First, calorie density plays a powerful role. In a randomized crossover trial, participants ate 813 more calories per day when consuming ultra-processed foods, even though meals had identical calories and macronutrients. Foods engineered to be hyper-palatable often pack in calories without promoting fullness.

Next, we dive into satiety—that subjective feeling of fullness. A Satiety Index study found that boiled potatoes, oatmeal, apples, and beef left participants feeling fuller than white bread or croissants. Why? One reason might be energy density, as demonstrated in another trial where high-fat lunches led participants to eat nearly 500 extra calories.

We also explore food texture. In a study comparing soft vs. hard meals, participants consumed 20% more from softer options. A similar principle applies to fruit vs. fruit juice, where a five-week trial showed that eating a whole apple before a meal reduced calorie intake by 187 calories compared to juice.

Protein also emerges as a standout. In a small study, a protein-based snack delayed hunger by 60 minutes—far more than fat or carbs. And then there’s hydration. Drinking water before meals may curb appetite, supported by a randomized trial and a systematic review showing that two cups of water before each meal led to significant weight loss over 3–12 months.

Finally, we can’t ignore the psychological piece. In the “sham milkshake” study, participants felt fuller—and had altered hunger hormone levels—based solely on what they thought they were consuming. Mind over matter, indeed.

Throughout the episode, I encourage listeners to explore these ideas with an N of 1 trial, as detailed in Episode 27

Try a protein-rich snack before dinner or a glass of water before meals and see how it changes your appetite.

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Are you doing too much in the name of health?
Between supplements, saunas, organic food, and brain games, wellness can feel like a second full-time job. In this episode, I help you filter the noise and focus on what really matters—so you can live long and well without losing your joy in the process.

We break down:

• The true opportunity cost of wellness routines like cold plunges, meditation, and restrictive diets
• The Pareto Principle (80/20 rule) in health: How to get 80% of the benefit with 20% of the effort
• The “Big 6” evidence-based habits that actually move the needle on longevity and function
• How to personalize your wellness plan based on lifespan, healthspan, and joyspan
• Your health type: Are you a Holistic Hacker or a Contentment Creator? Take the quiz to find out.

🧠 Referenced Research & Data:

• 1 in 2 men and 1 in 3 women will develop cardiovascular disease in their lifetime (PubMed)
• Stroke and dementia share many preventable risk factors like blood pressure and exercise (Alzheimer’s Association)
• 4 in 10 people will get cancer in their lifetime (American Cancer Society)
• Americans spend ~9 hours sleeping and ~4 hours on leisure daily (Bureau of Labor Statistics)

🎯 Takeaways:

• Not all health habits are equally impactful. Focus first on sleep, blood pressure, cholesterol, weight, exercise, and screenings.
• Prioritize based on what you value: functional longevity or joyful living—or both.
• Give yourself permission to not do it all. Your health plan should be sustainable, not exhausting.

🔗 Mentioned Tools:

• Live Long & Well Quiz
  
  
• Episode 13: Preventing Cognitive Decline
• Episode 18 & 37: Reducing Cardiovascular Risk
• Episode 21: What’s Your Health Type?

🧘‍♂️ Whether you’re a Purposeful Path Planner or a Holistic Health Hacker, this episode helps you reclaim your time, your joy, and your long-term health.

🔔 Subscribe for research-backed health insights in under 30 minutes—without the wellness overwhelm.