In this episode of Kidney Commute: Pitstop, we explore key insights from the upcoming KDOQI Commentary on the 2025 KDIGO Clinical Practice Guideline for autosomal dominant polycystic kidney disease (ADPKD). Host Anna Gaddy is joined by Dr. Neera Dahl and Dr. Terry Watnick to discuss how the updated recommendations differ from prior guidance and what they mean for real world practice in the United States. The conversation highlights advances in genetic testing, practical considerations for implementing tolvaptan therapy, and emerging therapies on the horizon. Tune in for actionable takeaways to support clinical decision making and improve care for patients with ADPKD.

Access the commentary here: https://www.ajkd.org/article/S0272-6386(26)00003-X/fulltext

Hosted by Dr. Sam Kant, this Kidney Commute: Pit Stop episode explores the Cerebronephrology region of NephMadness 2026 and the emerging concept of the brain–kidney axis. Drs. David Drew and Colton Jensen examine how chronic kidney disease and ESKD with dialysis contribute to cognitive impairment—an underrecognized complication affecting a large proportion of patients. From early microvascular injury, albuminuria, and hypertension in CKD to cerebral hypoperfusion, ischemia, and structural brain changes during dialysis, this discussion highlights the bidirectional relationship between kidney and brain health. Join us as we unpack where brain injury begins and what this means for earlier recognition and improved patient care.

This podcast explores the critical role of oral health in kidney transplant eligibility and outcomes. Through an interprofessional discussion, learners will examine how oral health impacts infection risk, transplant readiness, and long-term success. Notably, this episode features the valuable perspective of a dentist, highlighting the importance of integrating dental expertise into transplant care. Practical strategies for prevention, care coordination, and addressing access barriers will be highlighted to support patient-centered transplant care.

Advances in genetics have transformed how we understand kidney disease, and the discovery of APOL1 has been a major milestone. In this episode of Kidney Commute: Pitstop, host Dr. Osama El Shamy is joined by Meyeon Park, MD, MAS and Denay Richards, PhD to explore the role of APOL1 genetic variants in kidney disease development and progression.

The discussion covers the epidemiology of APOL1, the interplay between genetic risk and environmental factors, and scenarios in which APOL1 genetic testing may be considered. Speakers also address how test results are communicated to patients and families, implications for disease management, emerging research into APOL1 targeted therapies, and the significance of newly introduced ICD 10 codes for APOL1 mediated kidney disease.

After listening to the podcast, please complete the survey at https://kidneyforms.tfaforms.net/4728148.

This educational episode is supported by Vertex Pharmaceuticals.

Legislation has played a defining role in how dialysis care is delivered in the United States, directly influencing access, coverage, and patient choice. In this episode of Kidney Commute: Pitstop, host Osama El Shamy, MD, FASN, FNKF, is joined by Lauren Drew, JD, and Eugene Lin, MD, MS, FASN for an in depth discussion on the policy decisions that have shaped kidney care.

The conversation traces key legislative milestones, including the creation of the ESRD benefit, the Medicare dialysis bundle, Medicare Advantage expansion, and the Advancing American Kidney Health Initiative. Speakers also examine the current legislative landscape, its impact on dialysis patient choice, and opportunities for professional advocacy in kidney care.

Is dialysis nephrology’s greatest achievement or its original sin? In this Kidney Commute: Pit Stop episode, host Dr. Osama El Shamy, welcomes Dr. Andrew Cohen, to discuss a provocative question that challenges how the field of nephrology has evolved. Drawing from Dr. Cohen’s recent AJKD publication, the conversation explores key historical milestones, including early innovations, the 1972 Medicare amendment, and the rise of corporatized dialysis care. Together, they examine how these forces have shaped trainee perceptions, workforce recruitment, and the identity of nephrology today. The episode concludes with a forward-looking discussion on how the field can refocus priorities, embrace innovation, and chart a more balanced path beyond dialysis-centered care.

AJKD Article: https://www.ajkd.org/article/S0272-6386(25)00711-5/abstract

Navigating the transition from pediatric to adult kidney transplant care is one of the most pivotal and vulnerable periods for young patients. In this episode of the Kidney Commute, an interdisciplinary panel of nephrology, social work, nursing, pharmacy experts, and a kidney transplant recipient explore the medical, psychological, and social complexities that shape a successful transition. The discussion addresses readiness for independence, medication and insurance changes, adherence challenges, family dynamics, and coordinated handoffs between pediatric and adult teams. Through real-world insights and practical strategies, this episode highlights approaches to support continuity of care, protect graft survival, and empower young adults as they move into adult-centered transplant care.

This episode is complemented by additional insights from a psychologist who was unable to join the discussion; related resources are available at this link.

In this Kidney Commute: Pitstop episode, host Anna Gaddy, MD, FASN, FNKF, is joined by Kaice LaFavers, PhD, and Pranav Garimella, MBBS, MPH, to explore uromodulin. They discuss its role in infection defense, immune modulation, AKI and sepsis, genetic insights, and evolving methods to study its multiple forms. A concise, science driven look at why uromodulin matters in kidney health.