Episodios

  • Psychedelic science: How LSD could reshape anxiety treatment
    Sep 11 2025
    Researchers have conducted a rigorous clinical trial examining LSD as a treatment for generalized anxiety disorder, with results published in the Journal of the American Medical Association showing promising outcomes for patients who have struggled to find relief with existing medications.Cleveland Clinic psychiatrist Dr. Brian Barnett, who participated in the multi-site study, says the findings address a critical gap in mental health treatment. About one-third of patients with psychiatric conditions don't respond to any existing treatments, affecting millions of Americans with depression, anxiety and other disorders."Our existing treatments, there's a little variability depending on the particular condition, but generally about a third of patients with a particular condition will not respond to any psychiatric treatment," said Barnett. "So, when you think about that at scale, that's millions of people who have depression, anxiety, bipolar disorder that's not responding to treatment."The Phase 2b study, conducted by Mind Medicine Inc., involved 198 adults with moderate-to-severe generalized anxiety disorder across 22 psychiatric research sites in the United States. Participants received a single dose of MM120, a pharmaceutical-grade form of LSD, at varying strengths or a placebo.The most effective dose, 100 micrograms, showed significant improvements in anxiety symptoms that lasted throughout the 12-week observation period. Patients receiving this dose experienced a 7.6-point greater reduction in anxiety scores compared to those taking placebo, with 65% showing clinical response and 48% achieving clinical remission by week 12."About half of people were in remission from their generalized anxiety disorder 12 weeks after receiving a 100 microgram dose, so they no longer met criteria for generalized anxiety disorder," Barnett explained in an interview with WKYC's Monica Robins. "It's pretty impressive findings.""This study is a true turning point in the field of psychiatry," said Dr. Maurizio Fava, study author and Chair of Mass General Brigham Department of Psychiatry. "For the first time, LSD has been studied with modern scientific rigor, and the results are both clinically meaningful and potentially paradigm-shifting for the treatment of GAD."While researchers aren't entirely sure how psychedelics work therapeutically, Barnett explains they're believed to activate certain brain receptors and enhance neuroplasticity, making it easier for patients to learn new behaviors and thought patterns.The treatment showed results that appeared twice as effective as traditional medications like Prozac or Xanax when compared to historical studies, though Barnett cautions that direct head-to-head comparisons would be needed to confirm this finding.Generalized anxiety disorder affects approximately 26 million American adults, causing persistent worry that interferes with daily activities. Current first-line treatments fail about 50% of patients, and no new medications have been approved for the condition since 2007.Safety protocols for the study were extensive. About 90% of people with generalized anxiety disorder wouldn't qualify for these trials due to medical conditions like heart problems or history of bipolar disorder that could make psychedelic treatment risky."Safety is our number one priority in these trials," Barnett said. "We know that drugs like LSD are extremely powerful drugs, and if we're going to use them in medicine, then we have to do everything that we can to control the experience."During treatment sessions, participants are continuously monitored by two trained staff members in a controlled medical setting. Emergency medications are available if needed, though no serious adverse events occurred in the trials Barnett has conducted."There will never be a point where the FDA is going to approve sending psychedelics home with people," he emphasized. "They are drugs with strong psychoactive effects, so that's something we take very seriously."Side effects were consistent with LSD's known perceptual effects, including visual changes and nausea, occurring primarily on the day of treatment. Most adverse events were rated as mild-to-moderate and temporary.Based on these results, the FDA has granted Breakthrough Therapy Designation to MM120 for generalized anxiety disorder.Cleveland Clinic is currently enrolling patients for the Phase 3 trials, targeting 10 to 20 participants locally among several hundred nationwide. The trials will follow patients for a full year and allow multiple doses if needed, providing crucial information about how long benefits last.Many participants in the Phase 2 study eventually returned to traditional antidepressants, but often not until a year or more later, suggesting the psychedelic treatment provided substantial lasting benefits.Barnett doesn't consider this a "cure" for anxiety, noting that symptoms may return over time as they do with other psychiatric treatments. However, ...
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    15 m
  • Water Safety Tips Every Family Should Know
    Jul 22 2025
    Flash flooding dangersThe National Weather Service emphasizes a simple but critical message for flooding situations: "Turn around, don't drown." Driving or walking into flood waters is a major cause of fatalities, as water often moves faster or runs deeper than it appears.Flash flooding remains one of the leading causes of weather-related fatalities in the United States and can happen at any time of day or year. According to meteorologist Meredith Garafalo, flash flooding can occur in as little as a few minutes or after hours of continuous rain in the same location."It's especially dangerous at night because you can't always see the floodwaters," Garafalo explains.Two major contributing factors include the amount of rainfall and how long it persists. Urban areas, low-lying locations, and areas near rivers face particular risks due to limited water absorption and natural drainage patterns.Understanding the difference between watches and warnings is crucial. A flash flood watch means conditions are favorable for flooding, while a warning indicates conditions are imminent or already occurring.Different water environments present unique risksChildren aged five through fourteen are more likely to drown in natural bodies of water such as lakes, ponds, and rivers compared to swimming pools. These environments present distinct challenges that require specific safety awareness.Natural water bodies often have unpredictable currents, varying depths, and limited visibility. Unlike pools with controlled conditions, lakes and rivers can have sudden drop-offs, underwater obstacles, and changing weather conditions that affect water safety.Retention ponds, commonly found in residential areas, present particular dangers. As noted by the National Drowning Prevention Alliance, "they're not bodies of water to swim in." These man-made water features may appear calm but can have steep sides and murky water that conceals hazards.City officials have identified retention ponds as an ongoing concern, particularly for children with autism who may be drawn to these water sources near their homes. The challenge is that many of these drownings occur on private property, limiting municipal oversight and intervention capabilities.The tragedy becomes more pronounced for children with autism, who face drowning rates 160 times higher than their typically developing peers. This population is often drawn to water near their homes, making awareness and protective measures especially critical. An incident in Jacksonville, FL involved a 4-year-old boy with autism who was found in a retention pond in the Baymeadows area, highlighting the specific dangers these water features pose.Pool safety concernsDrowning deaths, particularly among children, increase during summer months, with July representing the peak period. For children between ages one and four, drowning is the leading cause of death, with a significant number of incidents occurring in home swimming pools.Tragic incidents underscore these dangers. Eight-year-old Christopher's body was discovered at the bottom of a swimming pool at a Holiday Inn in Strongsville where his family was staying. According to police call logs, the pool was checked at least three times before Christopher's body was found, almost nine hours after he was reported missing. The pool was described as "murky" and "cloudy," conditions that create serious safety hazards beyond just visibility issues.Murky pool water can harbor algae, harmful microorganisms, and bacteria that cause skin, respiratory, ear, and gastric infections. Such conditions can also host viral infections including norovirus and hepatitis A.Recognizing drowning signsContrary to Hollywood portrayals, real drowning incidents are much harder to spot than many people realize. For several years, Kevin Kreeger, Aquatics Director for Hastings Water Works, trained approximately 450 Northeast Ohio lifeguards each summer and emphasized that drowning is typically silent."The movie typically shows the person yelling and screaming for help. That's not what happens in real life," Kreeger explains. "They go into survival. They're trying to breathe. They don't call out for help."Drowning can progress to unconsciousness in less than two minutes, making constant vigilance essential for parents and caregivers.Prevention strategiesThe CDC recommends several key prevention steps: learning to swim, using life jackets, building barriers around pools, and maintaining constant supervision of children near water. Additional measures include avoiding alcohol and drugs before swimming, understanding natural water risks, and learning CPR.The National Drowning Prevention Alliance identifies five layers of protection: barriers and alarms, supervision, water competency, life jackets, and emergency preparedness.Bruce Barton, Chief of Pennsylvania Search and Rescue Recovery Team, emphasizes that many drowning incidents involve people not wearing personal flotation devices. He ...
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    17 m
  • Summer Health and Safety: Protecting Yourself from Heat, Medications, and Hidden Dangers
    Jul 7 2025
    Summer Health and Safety: Protecting Yourself from Heat, Medications, and Hidden DangersSummer brings fun in the sun, vacations, and relaxation for many of us. But with the season's pleasures come serious health risks that require our attention. From extreme heat waves to pesky mosquitoes carrying dangerous viruses, understanding summer safety is crucial for staying healthy during the warmer months.The Deadly Reality of HeatSummer arrived with a vengeance in parts of the country this year with sweltering heat waves, and it's likely not going to be the last. Many of us often forget the impact heat can have on us. According to the CDC, heat is the number one weather killer in the U.S., with heat-related illness claiming more than 1,200 people annually.Overexertion during the hottest time of the day is incredibly dangerous for those with heart or lung diseases. And if you take medications, the heat can cause serious side effects.How Your Medications React to HeatMost of us never think twice about the weather and our chronic illness, but that pill you take to treat your condition may not mix well with the heat."One thing that I think a lot of people don't know is that many medications can increase your risk and there are so many that can do it, most people are on one or another," said Dr. Ryan Marino from UH Cleveland Medical Center Emergency Medicine.Certain heart medications, such as beta blockers, blood pressure medications, and ACE inhibitors can imbalance electrolytes, cause dehydration, reduce thirst sensation, decrease ability to sweat, and reduce blood pressure, which increases risk of fainting and falls.Antidepressants and other psychiatric medications can affect the body's ability to regulate temperature and impair sweating. What's worse is you may not even realize it's happening."It can kind of blunt the response where you might have more of a warning sign and it might be that people might not realize it until they are significantly affected," Dr. Marino explained.Protecting Your Medications from HeatIt's important to stay hydrated and limit your exposure to heat and sunlight but remember to never let your medications get hot either. Never leave them in a hot car - they need to be stored in a cool, dry place.What about medications that get delivered in the mail? Dr. Brian Kuhn, a pharmacist at Banner University Medical Center, explains that medications typically want to be stored between 60 degrees Fahrenheit and about mid-80s."We don't expect that those medications degrade into toxic or potentially harmful substances. For the most part, if there's likely some alteration that's going to occur because of heat, it's likely that the medication will lose some potency or efficacy," Kuhn said.Your medication isn't going to magically turn into something harmful, but it might not do exactly what it needs to do. Pharmacists say you shouldn't worry so much about pills, but certain liquids might pose a problem.Kuhn notes that heat could cause things like insulin, Wegovy, or EpiPens to start breaking down, which means they won't work as well. Some mail order pharmacies say their packaging is weather resistant, but to make sure, you can have medications delivered to your office or somewhere else that's air conditioned.Pregnancy and Extreme Heat: A Serious RiskWhen it comes to heat, we know the young, old, and immunocompromised can be at risk, but many may not be aware of the serious risk extreme heat can have on pregnant women.Dr. Lyndsey Darrow, a professor of epidemiology at the University of Nevada, Reno, has made it her mission to study these effects. One of the pregnancy complications that has been associated with extreme heat is hypertensive disorders of pregnancy, including pregnancy-induced hypertension, preeclampsia, and eclampsia. These conditions pose serious risks to both the mother and baby and are predictors of maternal mortality.There are numerous other pregnancy complications linked to extreme heat, including gestational diabetes. Studies indicate that extreme heat is associated with preterm birth and fetal death, including miscarriage and stillbirth."We know that extreme heat increases the risks of cardiovascular and renal-related deaths, and it makes sense that these would be vulnerabilities during pregnancy when these organ systems are already under enormous strain," Dr. Darrow explained.The outcomes associated with extreme heat include preterm birth and early birth, which are strong predictors of both infant mortality and health trajectories over the life course. They're associated with neurological development and respiratory diseases like asthma.Once infants are born, they are more vulnerable to extreme heat due to immature thermal regulation and more surface area relative to their size. Research shows increased hospitalizations during heat waves for issues including diarrhea, digestive issues, and breathing problems. Multiple studies in the U.S. and Canada have shown an increased risk ...
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    18 m
  • Understanding Brain Aneurysms Before It's Too Late
    Mar 10 2025

    Monica Robins is not a medical doctor. All content presented in this program is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your personal doctor or qualified healthcare professional with any questions regarding your health or medical condition.

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    19 m
  • Surprising Medical Renaissance of Psychedelics
    Mar 7 2025

    Monica Robins is not a medical doctor. All content presented in this program is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your personal doctor or qualified healthcare professional with any questions regarding your health or medical condition.

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    28 m
  • Boost immunity naturally
    Feb 19 2025

    Monica Robins is not a medical doctor. All content presented in this program is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your personal doctor or qualified healthcare professional with any questions regarding your health or medical condition.

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    23 m
  • Vaccines explained by an infectious disease expert
    Jan 10 2025

    Monica Robins is not a medical doctor. All content presented in this program is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your personal doctor or qualified healthcare professional with any questions regarding your health or medical condition.

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    26 m
  • K-Clarity: Exploring Ketamine's Therapeutic Frontiers
    Nov 25 2024

    Monica Robins is not a medical doctor. All content presented in this program is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your personal doctor or qualified healthcare professional with any questions regarding your health or medical condition.

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    20 m