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What if a child’s own tumor could teach their immune system how to fight back? We sit down with Dr. Liggon from the University of Florida to unpack a first‑in‑kids, personalized mRNA lipid nanoparticle therapy designed for high‑grade glioma and osteosarcoma. Instead of chasing a single target, this approach isolates mRNA directly from each patient’s tumor and packages it into lipid nanoparticles, training the immune system against a wide range of cancer proteins. That personalization is the point: every dose is built for one child, aiming to overcome the limits of one‑size‑fits‑all immunotherapy.

We walk through the basket trial design and why starting with these two cancers matters, especially when relapse rates are high and outcomes are poor. Dr. Liggon shares early adult data from glioblastoma patients showing rapid immune activation within hours—fevers, chills, and transient hypotension—signs that the therapy is doing its job without dose‑limiting toxicities. We also get practical: the six‑week manufacturing timeline from tumor to vaccine, the use of radiation or a non‑specific priming LNP to bridge that gap, and how the team measures pharmacodynamic markers at two and six hours to understand dose response over repeated treatments.

Collaboration is the backbone of this work. Our PICU team partners closely with oncology and immunotherapy colleagues to deliver infusions safely, manage inflammatory side effects, and collect the data that will refine dosing and duration. Behind the scenes, a funding story comes to life: local seed backing from Stop Children’s Cancer of Gainesville sparked momentum that grew into support from the V Foundation, National Pediatric Cancer Foundation, Alex’s Lemonade Stand Foundation, and the National Cancer Institute. Looking forward, the plan is to expand this platform to medulloblastoma, DIPG, Ewing sarcoma, and rhabdomyosarcoma as phase one findings guide the next steps.

Tune in to hear how personalized mRNA can move from lab to bedside, what signals we’re tracking, and where this platform could go next. If this resonates, follow the show, share it with a colleague, and leave a review with the questions you want us to ask in future updates.

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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

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Pediatric surgeon Dr. Shawn Larson joins the Burn Podcast to discuss best practices in pediatric burn management—from initial assessment to long-term care. Learn key strategies for improving outcomes, minimizing complications, and supporting young patients through recovery.

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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

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This episode takes a closer look at tracheostomies in pediatric patients—why they’re performed, how children are cared for immediately after surgery, and what long-term management looks like. We start with the most common reasons for tracheostomies, including airway obstruction, prolonged ventilation needs, and certain congenital or neurologic conditions.

The discussion then moves into immediate post-operative care, emphasizing airway security, monitoring for complications, and the importance of skilled nursing and respiratory support. From there, we highlight the essentials of continuing care at home and in the hospital, such as routine trach changes, suctioning, infection prevention, and family education.

Finally, we cover the process of decannulation, including readiness assessments, gradual trials, and multidisciplinary involvement to ensure safety and success.

The key message: with proper care and support, pediatric patients with tracheostomies can thrive, and decannulation is a realistic goal for many children.

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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

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This episode discusses CLABSI prevention bundles.

References
Johns Hopkins All Children’s Hospital. (2019, April 25). Oral care & chemotherapy: Oral hygiene before, during and after chemotherapy treatment [Patient information handout]. https://www.hopkinsallchildrens.org
Johns Hopkins All Children’s Hospital. (n.d.). Helping to prevent CLABSIs [Patient education handout]. https://hpo-docs.jh.edu/PPxSoEve
Scaramuzzo, L. a. S. M. R., Msn, Rn-Bc, Aocn, & Walton, A. W. R. B. C., Rn, Bsn, Cmsrn, Ocn. (2024, May 2). Evidence-Based Practices, No CLABSIs achieved through quality improvement. Oncology Nurse Advisor. https://www.oncologynurseadvisor.com/features/evidence-based-practices-no-clabsis-achieved-through-quality-improvement/2/

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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

PICU Essentials on the App Store (apple.com)

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This episode discusses training and resources in CLABSI prevention.

References
Johns Hopkins All Children's Hospital. (2025, April 25). Vascular access (Policy No. CLNPOL079; Version 11.3). In Clinical policies and practice guidelines (p. 5). https://hpo-docs.jh.edu/wQveJ1YW

Please take the survey using the link below:
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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

PICU Essentials on the App Store (apple.com)

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This episode is an introduction to CLABSI.

References
Gaur, A. H., Bundy, D. G., Gao, C., Werner, E. J., Billett, A. L., Hord, J. D., Siegel, J. D.,
Dickens, D., Winkle, C., & Miller, M. R. (2013). Surveillance of Hospital-Acquired
Central Line–Associated bloodstream infections in Pediatric Hematology-Oncology
patients Lessons learned, challenges ahead. Infection Control and Hospital Epidemiology,
34(3), 315–320. https://doi.org/10.1086/669513
Haddadin, Y., Annamaraju, P., & Regunath, H. (2022, November 26). Central Line–Associated
blood stream infections. StatPearls - NCBI Bookshelf.
https://www.ncbi.nlm.nih.gov/books/NBK430891/

Please take the survey using the link below:
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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

PICU Essentials on the App Store (apple.com)

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In this episode, we explore pediatric sepsis, a leading cause of critical illness and mortality in children worldwide. We discuss what sepsis is—the body’s overwhelming and life-threatening response to infection—and why children are uniquely vulnerable. The conversation highlights early recognition, focusing on key warning signs such as fever, tachycardia, tachypnea, and altered mental status.

We emphasize the importance of timely intervention: rapid antibiotics, fluid resuscitation, and escalation of care in the pediatric intensive care unit when necessary. The episode also covers evolving guidelines, best practices in sepsis bundles, and the role of teamwork in improving outcomes.

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References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

PICU Essentials on the App Store (apple.com)

PICU Essentials - Apps on Google Play

Send us a text

This podcast highlights the importance of oral care in the ICU.

CDC (2020). Ventilator-Associated Event (VAE) Surveillance Manual. https://www.cdc.gov/nhsn/pdfs/pscmanual/10-vae_final.pdf

Imai, K., Iinuma, T., & Sato, S. (2021). Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. The Japanese Dental Science Review, 57, 224–230. https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1016%2fj.jdsr.2021.10.003&umid=c9d01824-5246-4959-a2d9-e800f20fcd10&rct=1756489460&auth=97fad1ab76126251d3eed843752929f8915193a6-8b0c33aa44bd060ab3435662fa8cda3f7d379545

Takahama, A., Jr, de Sousa, V. I., Tanaka, E. E., Ono, E., Ito, F. A. N., Costa, P. P., Pedriali, M. B. B. P., de Lima, H. G., Fornazieri, M. A., Correia, L. S., Cardoso, L. T. Q., & de Maio Carrilho, C. M. D. (2021). Analysis of oral risk factors for ventilator-associated pneumonia in critically ill patients. Clinical oral investigations, 25(3), 1217–1222. https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2fs00784%2d020%2d03426%2dx&umid=c9d01824-5246-4959-a2d9-e800f20fcd10&rct=1756489460&auth=97fad1ab76126251d3eed843752929f8915193a6-c36d50ca1a740dc3bff1fffe2ec84a3178ac6d36

Please take the survey using the link below:
https://ufl.qualtrics.com/jfe/form/SV_8whTtydadAMpx7o

References:

Kline-Tilford, A. M., & Haut, C. (2020). Cases in pediatric acute care: Strengthening clinical decision making. Wiley-Blackwell.

Additional Resources:

PICU Essentials on the App Store (apple.com)

PICU Essentials - Apps on Google Play