Episodios

  • I. C. D. Driving Risk Predicted by Baseline Data. 01/11/26

    I. C. D. Driving Risk Predicted by Baseline Data. 01/11/26
    Jan 11 2026
    Welcome to Cardiology Today – Recorded January 11, 2026. This episode summarizes 5 key cardiology studies on topics like left ventricular ejection fraction and Implantable cardioverter-defibrillator. Key takeaway: I. C. D. Driving Risk Predicted by Baseline Data.. Article Links: Article 1: Sensitization in Organ Transplantation: Assessment of Risk (STAR) 2025 Meeting Group Report. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Phenotypic stratification and prognostic value of cardiac magnetic resonance in non-dilated left ventricular cardiomyopathy. (Heart (British Cardiac Society)) Article 3: Predicting the risk of motor vehicle crash in the first year after cardioverter-defibrillator implantation. (Heart (British Cardiac Society)) Article 4: Early predictors of aortic valve surgery in patients with significant bicuspid aortic regurgitation without initial surgical indication. (Heart (British Cardiac Society)) Article 5: Insomnia symptom trajectories and incident cardiovascular disease in older adults: a longitudinal cohort study. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/i-c-d-driving-risk-predicted-by-baseline-data-01-11-26/ Featured Articles Article 1: Sensitization in Organ Transplantation: Assessment of Risk (STAR) 2025 Meeting Group Report. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519473 Summary: The S. T. A. R. initiative’s working group has held three consensus meetings and published reports that have influenced clinical care in organ transplantation. The 2025 group identified and addressed five key evolving areas in transplantation: donor-derived cell-free D. N. A. tests, innate immunity in allograft rejection, immunogenicity and antigenicity, and H. L. A. antibody quantification. This demonstrates the group’s ongoing work in translating laboratory data into clinical practice and guiding future research priorities. Article 2: Phenotypic stratification and prognostic value of cardiac magnetic resonance in non-dilated left ventricular cardiomyopathy. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40819904 Summary: This study identified three distinct cardiac magnetic resonance-based phenotypes in 515 patients with non-dilated left ventricular cardiomyopathy. These phenotypes include late gadolinium enhancement positive with preserved left ventricular ejection fraction, late gadolinium enhancement negative with dilated left atrium or right ventricle and preserved left ventricular ejection fraction, and late gadolinium enhancement negative with isolated systolic dysfunction with preserved left ventricular ejection fraction. The classification of these phenotypes provides a new framework for risk stratification in this patient population. Article 3: Predicting the risk of motor vehicle crash in the first year after cardioverter-defibrillator implantation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40555466 Summary: This study utilized 22 years of population-based administrative data to identify licensed drivers who received a first implantable cardioverter-defibrillator between 1998 and 2018. It developed a method using baseline health and driving data, along with logistic regression, to estimate the risk of motor vehicle crash in the first year post-implantation. This approach provides clinicians with a tool to personalize medical driving restrictions following implantable cardioverter-defibrillator implantation. Article 4: Early predictors of aortic valve surgery in patients with significant bicuspid aortic regurgitation without initial surgical indication. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40541293 Summary: This study identified a cohort of 335 patients with moderate or severe bicuspid aortic regurgitation who did not initially meet guideline-based criteria for aortic valve surgery. These patients were drawn from a single-center registry of 1927 individuals with bicuspid aortic valve, excluding those with severe aortic stenosis, endocarditis, or other major valvular diseases. The study establishes the critical need for identifying early predictors of disease progression within this specific high-risk subgroup to aid in optimal risk stratification and surgical timing. Article 5: Insomnia symptom trajectories and incident cardiovascular disease in older adults: a longitudinal cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40425274 Summary: This longitudinal cohort study of 12000 participants aged 50 years or older investigated the associations between insomnia symptoms, their long-term ...
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  • HoFH Therapy: New Drug Bypasses LDL Receptor 01/10/26

    HoFH Therapy: New Drug Bypasses LDL Receptor 01/10/26
    Jan 10 2026
    Welcome to Cardiology Today – Recorded January 10, 2026. This episode summarizes 5 key cardiology studies on topics like SHR-1918 and clinical outcomes. Key takeaway: HoFH Therapy: New Drug Bypasses LDL Receptor. Article Links: Article 1: Congenital heart defects: familial recurrence patterns in Sweden. (European heart journal) Article 2: Cardiovascular adaptation to training load in endurance athletes: a longitudinal study. (European heart journal) Article 3: Serial Assessment of Modified SCAI SHOCK Classification in Post-Cardiotomy Patients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Anti-ANGPTL3 Antibody SHR-1918 for Homozygous Familial Hypercholesterolemia: A Nonrandomized Clinical Trial. (JAMA cardiology) Article 5: Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/hofh-therapy-new-drug-bypasses-ldl-receptor-01-10-26/ Featured Articles Article 1: Congenital heart defects: familial recurrence patterns in Sweden. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41504464 Summary: Congenital heart defects aggregate in families, necessitating updated population-based recurrence estimates due to improved survival and diagnostic precision. A comprehensive retrospective population-based case-control study utilized nationwide Swedish register data. This investigation included 51778 individuals diagnosed with congenital heart defects born between 1987 and 2001. The study established the specific familial recurrence patterns for congenital heart defects within the Swedish population. Article 2: Cardiovascular adaptation to training load in endurance athletes: a longitudinal study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41499247 Summary: The study demonstrated cardiovascular adaptation to training load in endurance athletes, linking objectively quantified exercise duration and intensity to cardiac magnetic resonance findings. Researchers correlated heart rate monitor data with cardiac magnetic resonance results in 69 young male endurance athletes, aged 16 to 23 years, and 82 middle-aged male endurance athletes, aged 45 to 70 years. This approach provided a precise characterization of exercise-induced cardiac remodeling, overcoming the limitations of previous studies that relied on self-reported data. It directly showed specific cardiac structural and functional changes in response to measured training loads. Article 3: Serial Assessment of Modified SCAI SHOCK Classification in Post-Cardiotomy Patients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513116 Summary: Post-cardiotomy shock is a severe complication after cardiac surgery, linked to high in-hospital mortality. The Society for Cardiovascular Angiography and Interventions SHOCK classification provides a valid approach for initial shock staging post-surgery. This study externally validated the prognostic value and accuracy of serial Society for Cardiovascular Angiography and Interventions SHOCK reclassification for all-cause in-hospital mortality. The data confirmed that repeated application of the classification offers improved risk assessment and predicts outcomes in post-cardiotomy patients. Article 4: Anti-ANGPTL3 Antibody SHR-1918 for Homozygous Familial Hypercholesterolemia: A Nonrandomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41499141 Summary: Homozygous familial hypercholesterolemia is a rare, life-threatening genetic disorder resulting in markedly elevated low-density lipoprotein cholesterol levels due to absent or severely impaired low-density lipoprotein receptor activity. Traditional lipid-regulating agents are largely ineffective as their activity relies on residual low-density lipoprotein receptor function. This nonrandomized clinical trial demonstrated that the anti-angiopoietinlike 3 antibody SHR-1918 reduced lipid levels through a low-density lipoprotein receptor-independent pathway. The study confirmed SHR-1918 as a viable therapeutic option for homozygous familial hypercholesterolemia, addressing a critical unmet need. Article 5: Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41499131 Summary: Area-based indicators of social determinants of health are associated with higher risk for acquired heart disease. This multicenter, prospective cohort study demonstrated the association of these area-based social determinants of health with clinical outcomes in patients with hypertrophic cardiomyopathy. The study, involving US adult patients with hypertrophic cardiomyopathy from 5 ...
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  • A. I. for Continuous Q. T. Monitoring 01/09/26

    A. I. for Continuous Q. T. Monitoring 01/09/26
    Jan 10 2026
    Welcome to Cardiology Today – Recorded January 09, 2026. This episode summarizes 5 key cardiology studies on topics like MTEER and transcatheter interventions. Key takeaway: A. I. for Continuous Q. T. Monitoring. Article Links: Article 1: 2026 ACC/AHA Clinical Performance and Quality Measures for Patients With Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. (Journal of the American College of Cardiology) Article 2: Deep Learning-Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation. (Circulation) Article 3: Air pollution, meteorological factors, and cardiac remodelling in children: a multi-omics cohort study. (European heart journal) Article 4: VENOPULMONARY EXTRACORPOREAL LIFE SUPPORT: AN ELSO REGISTRY ANALYSIS. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Contemporary Operator Procedural Volumes and Outcomes for TAVR and MTEER in the US. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/a-i-for-continuous-q-t-monitoring-01-09-26/ Featured Articles Article 1: 2026 ACC/AHA Clinical Performance and Quality Measures for Patients With Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41505788 Summary: C. C. / A. H. A. Clinical Performance and Quality Measures for Patients With Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. The 2026 American College of Cardiology/American Heart Association Clinical Performance and Quality Measures for Patients With Peripheral Artery Disease provide guidance for clinicians, researchers, and quality assurance personnel. These measures establish standards for assessing the effects of treatment decisions, including specific medications and diagnostic tests for individuals with peripheral artery disease. They serve to standardize care and facilitate quality assurance in clinical practice and research for this patient population. Article 2: Deep Learning-Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41460938 Summary: T. Monitoring to Identify High-Risk Prolongation Events After Class Three Antiarrhythmic Initiation. A deep learning system called 3DRECON-QT was developed for continuous Q. T. monitoring to identify high-risk Q. T. prolongation events. This system addresses drug-induced Q. T. prolongation that can occur after initiation of class three antiarrhythmics during outpatient care. 3DRECON-QT reconstructs spatial information from a single lead vector to quantify Q. T. and Q. T. corrected intervals. Its development provides a novel approach for identifying high-risk Q. T. prolongation, overcoming limitations of current insertable cardiac monitors. Article 3: Air pollution, meteorological factors, and cardiac remodelling in children: a multi-omics cohort study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41511488 Summary: A multi-omics cohort study investigates the effects of air pollution and meteorological factors on cardiac remodeling in children. A total of 2029 children were enrolled in the Southwest Health Children Cohort in China to provide crucial data on these exposures. This research illuminates how environmental factors influence cardiovascular structure and function and the underlying biomolecular mechanisms in pediatric populations. The study addresses a critical knowledge gap regarding these effects in children, contrasting with established associations in adults. Article 4: VENOPULMONARY EXTRACORPOREAL LIFE SUPPORT: AN ELSO REGISTRY ANALYSIS. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41506589 Summary: L. S. O. Registry Analysis. This Extracorporeal Life Support Organization registry analysis provides real-world outcomes for adults receiving venopulmonary extracorporeal life support. The study utilized a large sample size from the E. L. S. O. registry to describe patient experiences across various clinical conditions. It establishes data regarding the current use, adverse events, and prognostic drivers for venopulmonary extracorporeal life support, where previous information was limited. Article 5: Contemporary Operator Procedural Volumes and Outcomes for TAVR and MTEER in the US. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41505119 Summary: S. This cohort study investigated...
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  • CXCR6+ T Cells Drive ICI Myocarditis 01/07/26

    CXCR6+ T Cells Drive ICI Myocarditis 01/07/26
    Jan 8 2026
    Welcome to Cardiology Today – Recorded January 07, 2026. This episode summarizes 5 key cardiology studies on topics like major adverse cardiovascular events and heart failure. Key takeaway: CXCR6+ T Cells Drive ICI Myocarditis. Article Links: Article 1: Loss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men. (Journal of the American College of Cardiology) Article 2: Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure. (Journal of the American College of Cardiology) Article 3: CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis. (Circulation) Article 4: Prognostic Implications of Evolving Universal Definitions of Periprocedural Myocardial Infarction in Patients With Acute Coronary Syndrome. (Circulation) Article 5: Inhibition of Annexin A2 Facilitates PHB2-Mediated Mitophagy in Cardiomyocytes to Alleviate Cardiac Injury and Remodeling After Infarction. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/cxcr6-t-cells-drive-ici-myocarditis-01-07-26/ Featured Articles Article 1: Loss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41498476 Summary: Loss of the Y chromosome from circulating leukocytes is common in older men and is definitively associated with increased cardiovascular risk. This genetic phenomenon functions as a predictor for incident major adverse cardiovascular events, including myocardial infarction and ischemic stroke. The association was investigated in a prospective cohort of 5131 men aged 65 years or older, providing a clear link in a healthy patient population. This indicates the role of genetic factors in cardiovascular disease progression in older males. Article 2: Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41196240 Summary: Frailty is highly prevalent among patients with heart failure and consistently correlates with adverse clinical outcomes. The Clinical Frailty Scale accurately captures multidimensional vulnerability, reflecting both physical and cognitive decline in this patient population. This scale demonstrates significant prognostic utility, predicting 2-year all-cause mortality in hospitalized patients with heart failure. The findings establish the Clinical Frailty Scale as a robust tool for risk stratification in contemporary heart failure care. Article 3: CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41498147 Summary: X. C. R. 6 Positive T Cells Drive Immune Checkpoint Inhibitor Myocarditis. Myocarditis is a severe and established complication of immune checkpoint inhibitor therapy, with a major risk factor being the use of combination treatments, particularly relatlimab combined with anti-programmed cell death protein 1 therapy. This study definitively identified C. X. C. R. 6 positive T cells as the specific T-cell population responsible for driving immune checkpoint inhibitor myocarditis. The research revealed the critical signaling pathways and T-cell populations that lead to cardiac infiltration in this adverse event. These findings provide a clear understanding of the pathogenic mechanisms underlying immune checkpoint inhibitor myocarditis. Article 4: Prognostic Implications of Evolving Universal Definitions of Periprocedural Myocardial Infarction in Patients With Acute Coronary Syndrome. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493005 Summary: Universal definitions of percutaneous coronary intervention-related myocardial infarction have undergone substantial updates, including an increase in biomarker thresholds from three to five times the upper reference limit. New ancillary criteria, such as ischemic symptoms, electrocardiographic changes, or angiographic complications, have also been introduced. These evolving definitions directly impact the diagnosis and prognostic assessment of patients with acute coronary syndrome. The changes have significant implications for patient risk stratification and treatment strategies following percutaneous coronary intervention. Article 5: Inhibition of Annexin A2 Facilitates PHB2-Mediated Mitophagy in Cardiomyocytes to Alleviate Cardiac Injury and Remodeling After Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41492949 Summary: H. B. 2-Mediated Mitophagy in Cardiomyocytes to Alleviate Cardiac Injury and Remodeling After Infarction. Mitophagy is critically involved in cardiac injury and repair processes following myocardial infarction. The annexin A family of proteins plays an important role in regulating mitophagy. This study established that the inhibition of annexin A2 facilitates P. H. B. 2-...
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  • RBMS1 Deficiency Improves Heart Failure 01/05/26

    RBMS1 Deficiency Improves Heart Failure 01/05/26
    Jan 5 2026
    Welcome to Cardiology Today – Recorded January 05, 2026. This episode summarizes 5 key cardiology studies on topics like left ventricular diastolic dysfunction and transcatheter aortic valve replacement. Key takeaway: RBMS1 Deficiency Improves Heart Failure. Article Links: Article 1: Major arrhythmias in non-dilated left ventricular cardiomyopathy: a novel prediction score. (European heart journal) Article 2: Deficiency of the RNA-binding protein RBMS1 improves myocardial fibrosis and heart failure. (European heart journal) Article 3: Coronary access after TAVR with the 4th and 5th -generation self-expanding Evolut valves: The EPROMPT-CA study. (International journal of cardiology) Article 4: Durability of sotatercept response in pulmonary hypertension: Insights from extended real-world follow-up. (International journal of cardiology) Article 5: Impact of Left Ventricular Diastolic Function on Right Ventricular Size and Function. (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography) Full episode page: https://podcast.explainheart.com/podcast/rbms1-deficiency-improves-heart-failure-01-05-26/ Featured Articles Article 1: Major arrhythmias in non-dilated left ventricular cardiomyopathy: a novel prediction score. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40678978 Summary: Researchers identified a cohort of 337 patients with non-dilated left ventricular cardiomyopathy, or NDLVC, without prior major arrhythmic events. The study developed a novel prediction score for the occurrence of the first major arrhythmic event in this patient population. Diagnostic workup including cardiac magnetic resonance, endomyocardial biopsy, and genetic testing contributed to the elements comprising this score. This prediction score facilitates improved risk stratification for serious arrhythmias in non-dilated left ventricular cardiomyopathy. Article 2: Deficiency of the RNA-binding protein RBMS1 improves myocardial fibrosis and heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40471706 Summary: This study found that a deficiency of RNA-binding motif single-stranded interacting protein 1, or RBMS1, significantly improved both myocardial fibrosis and heart failure. Researchers observed that RBMS1 levels were elevated in the hearts of heart failure patients and animal models. The deficiency of RBMS1 regulated alternative splicing, which subsequently reduced cardiac fibrosis. These findings demonstrate RBMS1 as a novel therapeutic target for heart failure and myocardial fibrosis. Article 3: Coronary access after TAVR with the 4th and 5th -generation self-expanding Evolut valves: The EPROMPT-CA study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41485619 Summary: This prospective study assessed coronary access immediately following transcatheter aortic valve replacement, or TAVR, using fourth and fifth-generation self-expanding Evolut F. X. and F. X. Plus valves. Researchers identified specific computed tomography predictors for selective coronary access in patients who underwent transfemoral TAVR. The study established the anatomical determinants that impact the feasibility of subsequent coronary interventions. These findings offer practical guidance for optimizing post-TAVR coronary access strategies in patients implanted with these latest Evolut valve platforms. Article 4: Durability of sotatercept response in pulmonary hypertension: Insights from extended real-world follow-up. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41485617 Summary: This retrospective cohort study compared 454 patients with primary pulmonary hypertension receiving sotatercept to 963386 primary pulmonary hypertension patients who did not receive the treatment. Researchers utilized data from a global federated health research network to analyze real-world long-term outcomes. The study established a comprehensive comparison of patient trajectories between the sotatercept-treated and untreated cohorts over an extended follow-up period. These findings offer critical data on the sustained real-world impact of sotatercept in pulmonary hypertension beyond short-term trial observations. Article 5: Impact of Left Ventricular Diastolic Function on Right Ventricular Size and Function. Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41485609 Summary: This study investigated the impact of various degrees of left ventricular diastolic dysfunction, or D. D., on right ventricular size and function. Researchers performed 3-dimensional imaging of the right ventricle in a broad sample of 370 patients undergoing echocardiography. The study established a direct relationship between lesser degrees of left ventricular ...
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  • Thromboaspiration Not Routine in STEMI 01/04/26

    Thromboaspiration Not Routine in STEMI 01/04/26
    Jan 4 2026
    Welcome to Cardiology Today – Recorded January 04, 2026. This episode summarizes 5 key cardiology studies on topics like quantitative flow ratio and sinus rhythm. Key takeaway: Thromboaspiration Not Routine in STEMI. Article Links: Article 1: Selective Use of Thromboaspiration in STEMI: CMR Evidence Against Routine Practice. (The American journal of cardiology) Article 2: Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease Versus Predominant Aortic Stenosis. (The American journal of cardiology) Article 3: Comparison of Functional Tricuspid Regurgitation Following Transcatheter Atrial Septal Defect Closure in Adult Patients With Sinus Rhythm, Post-ablation Sinus Rhythm, and Permanent Atrial Fibrillation. (The American journal of cardiology) Article 4: Persistent Racial Disparities in Chronic Limb-Threatening Ischemia Outcomes and Utilization Among US Medicare Patients. (The American journal of cardiology) Article 5: Unmasking Myocardial Bridge-Related Ischemia by Quantitative Flow Ratio Functional Evaluation. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/thromboaspiration-not-routine-in-stemi-01-04-26/ Featured Articles Article 1: Selective Use of Thromboaspiration in STEMI: CMR Evidence Against Routine Practice. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41483841 Summary: This study provided cardiac magnetic resonance imaging evidence against the routine use of thromboaspiration as an adjunct to primary percutaneous coronary intervention in ST-elevation myocardial infarction. The data demonstrated concerns about thromboaspiration’s potential to aggravate microvascular injury. The study confirmed that the effect of thromboaspiration on microvascular perfusion remains uncertain, leading to the conclusion that routine application is not supported. Article 2: Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease Versus Predominant Aortic Stenosis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138981 Summary: This meta-analysis compared the survival of patients with mixed aortic valve disease versus predominant aortic stenosis following transcatheter aortic valve replacement. The study found that patients with mixed aortic valve disease demonstrated distinct survival outcomes compared to those with predominant aortic stenosis. This research provides crucial insights into differential survival rates for specific aortic valve pathologies undergoing transcatheter aortic valve replacement (TAVR). Article 3: Comparison of Functional Tricuspid Regurgitation Following Transcatheter Atrial Septal Defect Closure in Adult Patients With Sinus Rhythm, Post-ablation Sinus Rhythm, and Permanent Atrial Fibrillation. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41061875 Summary: This study compared the sequential changes in functional tricuspid regurgitation following transcatheter atrial septal defect closure across different preprocedural cardiac rhythms. The research categorized patients into groups with sinus rhythm, sinus rhythm after catheter ablation for atrial fibrillation, and permanent atrial fibrillation. The data demonstrated differential changes in tricuspid regurgitation based on the patient’s baseline and post-ablation cardiac rhythm status after atrial septal defect closure. Article 4: Persistent Racial Disparities in Chronic Limb-Threatening Ischemia Outcomes and Utilization Among US Medicare Patients. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052695 Summary: This study demonstrated persistent racial disparities in chronic limb-threatening ischemia outcomes and healthcare utilization among U.S. Medicare patients. The data showed that Black patients continued to experience higher amputation rates and reduced access to vascular care compared to White beneficiaries. Despite national campaigns aimed at improving peripheral arterial disease outcomes, these disparities were found to persist over time. Article 5: Unmasking Myocardial Bridge-Related Ischemia by Quantitative Flow Ratio Functional Evaluation. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40914220 Summary: This study found that quantitative flow ratio functional evaluation effectively unmasked myocardial bridge-related ischemia. The data demonstrated that this functional assessment method is crucial for identifying the hemodynamic impact of myocardial bridges, which are segments of epicardial coronary arteries passing through myocardial muscle. The findings highlight the utility of quantitative flow ratio in assessing myocardial bridge severity for informed treatment decisions, particularly in cases where these bridges are associated with cardiovascular conditions. Transcript Today’s date is January 04, 2026. Welcome to Cardiology ...
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  • Epicardial Cells Regulate Ventricular Compaction 01/04/26

    Epicardial Cells Regulate Ventricular Compaction 01/04/26
    Jan 4 2026
    Welcome to Cardiology Today – Recorded January 04, 2026. This episode summarizes 5 key cardiology studies on topics like dendritic cells and allograft tolerance. Key takeaway: Epicardial Cells Regulate Ventricular Compaction. Article Links: Article 1: Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. (Transplantation) Article 2: Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. (Circulation. Heart failure) Article 3: Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. (The American journal of cardiology) Article 4: Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. (The American journal of cardiology) Article 5: Mini-Crush Versus Double Kissing Crush in Bifurcation Percutaneous Coronary Intervention: Insights From PROGRESS-BIFURCATION Registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/epicardial-cells-regulate-ventricular-compaction-01-04-26/ Featured Articles Article 1: Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691833 Summary: Researchers found that transmembrane protein 176B, an intracellular cation channel, is associated with allograft tolerance. The study demonstrated that this protein controls the tolerogenic function of dendritic cells and inhibits the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome. Activation of transmembrane protein 176B by a nitroalkene derivative of salicylate successfully prolonged graft survival. These findings reveal a mechanism by which transmembrane protein 176B activation contributes to sustained graft survival. Article 2: Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41477684 Summary: Researchers found that the invasion of epicardial-derived cells into the trabeculae regulates ventricular compaction. This crucial process is mediated by Numb and fibroblast growth factor signaling pathways. These findings establish a fundamental mechanism underlying normal ventricular compaction and provide significant insight into the pathogenesis of left ventricular noncompaction cardiomyopathy. Understanding this pathway offers a clearer picture of this prevalent pediatric cardiomyopathy. Article 3: Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41161558 Summary: This retrospective cohort study conducted a comparative analysis of outcomes for adults experiencing myocardial infarction and cardiogenic shock following coronary artery bypass graft surgery. The study directly compared patients who underwent percutaneous coronary intervention within 24 hours to those who did not. Researchers utilized propensity score matching and Fine-Gray models to derive adjusted and unadjusted hazard ratios and subdistribution hazard ratios for various outcomes. This comprehensive approach established a direct comparison of interventional strategies in this specific, high-risk patient population. Article 4: Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138985 Summary: A multi-cohort study successfully created and propensity score matched various cohorts to investigate the links between mitral annular calcification and heart failure with preserved ejection fraction. Researchers found that hospitalized patients without prior heart failure, when stratified by the presence or absence of mitral annular calcification, allowed for assessment of the risk of developing heart failure. These studies explored established associations and shared risk factors between mitral annular calcification and heart failure with preserved ejection fraction. This comprehensive analysis provides a foundational dataset for understanding their relationship. Article 5: Mini-Crush Versus Double Kissing Crush in Bifurcation Percutaneous Coronary Intervention: Insights From PROGRESS-BIFURCATION Registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138984 Summary: An observational, multicenter study compared procedural characteristics of patients undergoing two-stent bifurcation percutaneous coronary intervention using either the mini-crush or double kissing crush techniques. The study found that an international cohort from the PROGRESS-BIFURCATION registry was assembled for this comparative analysis...
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  • AI ECG Predicts Atrial Fibrillation Risk. 12/07/25

    AI ECG Predicts Atrial Fibrillation Risk. 12/07/25
    Dec 7 2025
    Welcome to Cardiology Today – Recorded December 07, 2025. This episode summarizes 5 key cardiology studies on topics like Aficamten and left ventricular dysfunction. Key takeaway: AI ECG Predicts Atrial Fibrillation Risk.. Article Links: Article 1: Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial. (JACC. Heart failure) Article 2: Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM. (Circulation. Heart failure) Article 3: Artificial intelligence-enabled electrocardiographic sex discordance and the risk of incident atrial fibrillation: a multi-national cohort study. (Heart rhythm) Article 4: High Subcutaneous Nerve Activity in Noise-Associated Ventricular Arrhythmias. (Heart rhythm) Article 5: Temporal Change in Right Ventricular Pacing Ratio and Its Association with Cardiac Function and Arrhythmia: A Linear Mixed-Effects Model Analysis. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/ai-ecg-predicts-atrial-fibrillation-risk-12-07-25/ Featured Articles Article 1: Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41351608 Summary: Finerenone is established to reduce the risk of worsening heart failure events and cardiovascular death. This benefit applies to patients with heart failure with mildly reduced or preserved ejection fraction. The FINEARTS-HF trial investigated whether this known efficacy of finerenone varies according to a patient’s baseline kidney function. Article 2: Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41347307 Summary: Aficamten, a cardiac myosin inhibitor, improved exercise capacity, health status, and symptoms in adults with obstructive hypertrophic cardiomyopathy, as demonstrated in the phase three SEQUOIA-HCM trial. This medication directly targets the underlying hypercontractility responsible for hypertrophic cardiomyopathy. The CEDAR-HCM trial is evaluating the efficacy and safety of aficamten in children and adolescents with obstructive hypertrophic cardiomyopathy, addressing a critical unmet need given the limited treatment options for pediatric hypertrophic cardiomyopathy. Article 3: Artificial intelligence-enabled electrocardiographic sex discordance and the risk of incident atrial fibrillation: a multi-national cohort study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41352445 Summary: This study successfully developed and externally validated an artificial intelligence enabled electrocardiogram model for sex prediction. The model achieved an Area Under the Curve of 0.91 on the C. O. D. E. minus 15 percent dataset and 0.90 on the M. I. M. I. C. minus I. V. dataset. This tool generates a sex discordance score, which provides a quantifiable measure related to incident atrial fibrillation risk beyond binary sex classification. Article 4: High Subcutaneous Nerve Activity in Noise-Associated Ventricular Arrhythmias. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41352444 Summary: Environmental noise acts as a contributing factor to cardiovascular disease and arrhythmias, a process linked to autonomic nervous system dysregulation. The mechanisms driving noise-induced arrhythmogenesis remain unclear. Understanding subcutaneous nerve activity and heart rate variability is crucial for elucidating the role of autonomic nervous system modulation in these ventricular arrhythmias. Article 5: Temporal Change in Right Ventricular Pacing Ratio and Its Association with Cardiac Function and Arrhythmia: A Linear Mixed-Effects Model Analysis. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41352443 Summary: Right ventricular pacing induces electrical and mechanical dyssynchrony, which can influence left ventricular dysfunction and contribute to heart failure. The long-term impact of temporal increases in the right ventricular pacing ratio on left ventricular remodeling and arrhythmia occurrence has been unclear. This retrospective longitudinal cohort study investigates these associations to provide crucial insights into patient management following right ventricular pacing implantation. Transcript Today’s date is December 07, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial. Finerenone is established to reduce the risk of worsening heart failure events and cardiovascular death. This benefit applies to patients with ...
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