Nearly a year and a half ago, we released the Season 2 episode “In Sickness and in Health,” which explored new anti-amyloid therapies for Alzheimer’s disease, lecanemab and donanemab, known commercially as Leqembi and Kisunla.

After more than three years of lecanemab and nearly two years of donanemab in clinical use, how do patients, caregivers, and clinicians view these treatments today?

In this episode of The Age of Aging, we revisit the therapies reshaping Alzheimer’s care and hear from those experiencing them firsthand.

Inside this episode

• Patients receiving anti amyloid therapy share reflections on treatment, uncertainty, and hope.

• Dr. Justin Clapp discusses research on how patients, caregivers, and clinicians understand these therapies.

• Dr. Kyra O’Brien reflects on prescribing the treatments and changes within clinical practice.

• Dr. Jason Karlawish shares perspectives from patient conversations and clinical care.

Resources available on the episode webpage linked below

• Listen to “In Sickness and in Health”

• Learn more about Justin Clapp

• Learn more about Kyra O’Brien

• More information on anti-amyloid therapies

Special thanks this episode to Dave and Evelyn, Justin Clapp, PhD, MPH, Kyra O’Brien, MD, Joanne and Bruce Thomas, Sandy Shulan, and Jason Karlawish, MD.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

We often think of dementia as an interior condition, one that happens within a person’s mind, independent of the outside world. However, as dementia and design experts note, we are in constant contact with our environments, and people with dementia are profoundly impacted by the spaces they occupy. How do we design a world for people with cognitive change? And what do the environments traditionally designed for older adults say about their current role in society? In this episode of The Age of Aging, we look at how architecture and design can both benefit those with dementia or become a detriment to their longevity.

Inside this episode:

• The Miracle Kitchen: Dr. Jason Karlawish discusses the Greenhouse Project and alternative approaches to dementia care design.

• The History of Concealment: Architectural historian Annmarie Adams explains how concealment has historically defined spaces for the sick and the elderly.

• Inclusive Design: Dementia Design Specialists Greg and Fiona Walsh share how they implement inclusive designs to reduce stress and promote independence.

Resources available on the episode webpage linked below

• Learn more about the Greenhouse Project

• Read “Concealment and Compassion” by Shannon Mattern

• Listen to Sally Chivers’ podcast, “Wrinkle Radio”

• Read “Deception and Design: The Rise of the Dementia Village”

• Explore the Alzheimer’s Foundation of America’s “The Apartment”

• Learn more about Shannon Mattern

• Learn more about Annmarie Adams

• Visit Fiona Kenney’s website

• Visit the Dementia Design Specialist Architects website

Special thanks this episode to Jason Karlawish, MD, Shannon Mattern, PhD, Annmarie Adams, PhD, Sally Chivers, PhD, Fiona Kenney, Greg Walsh, and Fiona Walsh.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Dalia ElSaid, Jason Karlawish, Emily Largent, and Alison Lynn.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.

Today’s episode is sponsored by The TIAA Institute, a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

Being intentional about our diet is one of the best things we can do for the health and longevity of our brain. But what exactly is a healthy brain diet—and how do we make it realistic?

In the season 5 premiere of the Age of Aging, we break down the science and strategy behind the MIND diet and what it looks like to shop and eat for cognitive longevity.

Inside this episode:

• Terrence sits down with Dr. Jason Karlawish to discuss the results and implications of the U.S. POINTER study for healthy brain aging.

• Dr. Karlawish explains the science behind the MIND diet and how he implements it in his daily life.

• Registered dietitian nutritionist (and Terrence’s sister) Trish St. Ledger shares how to create nutritious meals that are both simple and affordable. St. Ledger provides an overview of a what typical day of breakfast, lunch, and dinner might look like following the MIND diet.

Resources available on the episode webpage linked below

• More information on the MIND Diet (Cleveland Clinic)

• More information on healthy eating and longevity (National Institute on Aging)

• Learn more about Trish St. Ledger

Special thanks this episode to Jason Karlawish, MD and Trish St. Ledger, MS, RD, LDN.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.

In season 4 of the Age of Aging, we decided to end every interview with the same question: what do you wish people understood more about aging?

In this special bonus episode of the podcast, we share some of their answers. They remind us of the prevalence of ageism, the many benefits of old age, and that we always have the ability to grow and change at any age.

Special thanks this episode to Lucy Davenport, Andrew Borba, Amanda Lee Williams, James Bonas, Tracey Leigh, Leo Marks, Jennifer Craft Morgan, PhD, Bruce Miller, MD, Leah Lawler, Candace Kemp, PhD, and Jake Broder.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

The year 2025 was full of breakthroughs, debates, and big questions in Alzheimer’s research. One event that shaped many of these conversations? The Clinical Trials on Alzheimer’s Disease (CTAD) Conference. It may not have been on everyone’s radar, but its impact was undeniable.

In this special episode, Penn Memory Center Co-Directors Dr. Jason Karlawish and Dr. David Wolk share what stood out at CTAD, what’s changing in the field, and what to watch next.

Inside this episode:

• Anti-amyloid therapies update: Where things stand with lecanemab and donanemab, and what the next generation of these drugs could look like

• GLP-1 disappointment: Why Novo Nordisk’s semaglutide trials for Alzheimer’s disease came up short

• Lifestyle interventions: The latest findings from the POINTER Study and what they mean for brain health

Resources available on the episode webpage linked below

• Visit CTAD’s website

• More information on anti-amyloid therapies

• Novo Nordisk’s announcement of negative results “EVOKE” and “EVOKE+” trials

• More information on the POINTER Study

Special thanks this episode to Jason Karlawish, MD and David Wolk, MD.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

Art that tries to teach you things “stinks,” says playwright and actor Jake Broder.

“And yet there is a profound need for education, for awareness, for reducing stigma, for supporting the community and for medical education,” he said. A few years ago, while writing his latest play about the two individuals with frontotemporal dementia, he wrestled with how he could do both.

In the season 4 finale of the Age of Aging, we tell the story of UnRavelled, a play about perseverance through neurodegeneration, burgeoning creativity late in life and an artistic relationship across time. Producer Jake Johnson shares his first-hand experience of the play’s premiere and how it combined theater with community outreach and education.

What’s inside:

• A historical perspective on composer Maurice Ravel’s brain condition and his work, “Bolero.”

• An explanation from Dr. Bruce Miller on the relationship between frontotemporal degeneration and creativity.

• Jake Broder’s insight into the inspiration and creation of the play as well as the associated Brain Health Festival.
• The perspective of the show’s director and cast on creating the play and its core themes.

Resources available on the episode webpage linked below

• Listen to Maurice Ravell’s Bolero

• Learn more about Dr. Bruce Miller

• Listen to Unraveling Bolero (Radiolab)

• Learn more about Jake Broder

• More information on For Their Thoughts Foundation

• Visit the official website of UnRavelled

• Subscribe to the Age of Aging Newsletter

Special thanks this episode to Dr. Bruce Miller, Jake Broder, Betsy Hall, Lucy Davenport, James Bonas, Leo Marks, Tracy Leigh, and the entire UnRavelled team.

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

If you asked most caregivers, they would probably say there’s nothing funny about caring for someone with dementia. The stress, grief, and frustration can feel overwhelming. But what if the principles of improv comedy — being present, saying “yes,” and working together — could make caregiving easier and more joyful?

In this episode of the Age of Aging, we explore the surprising connection between improv and dementia care. You’ll hear how techniques from the stage are helping caregivers reduce stress, improve communication, and find moments of joy.

What’s inside:

• A peek inside the Penn Memory Center’s Cognitive Comedy class, where caregivers and people living with dementia learn improv basics.

• Dr. Anne Basting on why asking questions and staying present matters in tough caregiving moments.

• Improv teacher and elder care educator Karen Stobbe shares her personal story of using improv to care for her mother with Alzheimer’s.

• Researchers Dr. Candace Kemp, Dr. Jennifer Craft Morgan, and Amanda Lee Williams discuss the science behind improv’s benefits for caregivers.

• Leah Lawler, creator of Cognitive Comedy, explains why teaching improv to older adults is her passion.

Whether you’re a caregiver, a healthcare professional, or simply curious about creative approaches to aging, this episode offers practical insights and inspiring stories that will change the way you think about care.

Resources available on the episode webpage linked below

• Check out the Penn Memory Center’s Cognitive Comedy class

• Learn more about improv (UChicago News)

• Explore Timeslips’ website

• Learn more about Anne Basting

• Check out Karen Stobbe’s “In the Moment”

• Listen to Karen and Mondy’s story in This American Life

• Read Dr. Kemp and Dr. Morgan’s study on improv and dementia care (The Gerontologist)

• Watch more of Leah Lawler talking about Cognitive Comedy

• A list of improv games/exercises (improvencylcopedia.org)

Special thanks this episode to Jean Haskell and her Cognitive Comedy participants, Barry and Ray, as well as Anne Basting, PhD, Karen Stobbe, Candace Kemp, PhD, Jennifer Craft Morgan, PhD, and Amanda Lee Williams.

T Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

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Artificial intelligence is everywhere in 2025, and elder care is no exception. As the older adult population continues to grow, AI has the potential to provide desperately needed support. Both at home and in the hospital, AI systems are being developed that can summarize data, predict patient outcomes, and offer preventative interventions. These systems could help clinicians be more efficient as well as shoulder some of caregivers’ many responsibilities. Yet for as many problems as AI seems to solve in healthcare, many more questions arise as to how these innovative tools can be implemented ethically.

On this episode of the Age of Aging, we take a deep dive into the developing role of AI in the care of older adults.

We first hear from expert researchers in this space about the potential ways AI could be used to assist in the lives of older adults. Then, the co-founder of New Days AI, Dr. Babak Parviz, discusses how his company utilizes AI to help older adults protect against dementia. Finally, we look into the potential challenges and ethical questions that come with implementing AI in dementia care.

Resources available on the episode webpage linked below

• NASA’s definition of artificial intelligence

• Learn more about Dr. Alex Mihailidis

• More on Dr. George Demiris

• More information on Penn AI Tech

• Visit New Days AI’s website

• Learn more about Dr. Mai Lee Chang

• More information on Oonjee Oh

• “AI Photos” (Saturday Night Live)

Special thanks this episode to Alex Mihailidis PhD, PEng, George Demiris PhD, FACMI, Babak Parviz, PhD, Mai Lee Chang, PhD, and Oonjee Oh, MSN, RN

The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.

Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.