When archaeologist Zoe Miller’s cousin is abducted by a vicious Russian kidnapper, she must come to grips with a haunting secret. Unknown to even her closest friends, Zoe is not entirely human. She is a werewolf and a daughter of the "Fangborn", a hidden race of werewolves, vampires, and oracles. Zoe’s attempt to rescue her cousin leads her on a quest for artifacts - including Pandora’s Box, an object of world-ending power.

Archaeologist Zoe Miller has only recently learned she is Fangborn, a secretive race of werewolves, vampires, and oracles dedicated to protecting humanity. But after she discovered and opened Pandora’s Box, the fabled item has lived up to its myth, and for Zoe and her friends, all hell has broken loose. Now she’s on a double mission: to prevent a politician from revealing the existence of the Fangborn and to foil the diabolical plans of the powerful Order of Nicomedia, a group dedicated to eradicating her kind.

I-Day is near at hand, and soon the Fangborn will reveal themselves to humankind. As a member of this secretive race of werewolves, vampires, and oracles, will archaeologist Zoe Miller be prepared? Still grappling with the newfound powers she gained after opening Pandora's box, Zoe shares the responsibility of protecting "Normal" humans. Having long preferred to keep to the shadows, she knows the pending revelation of the Fangborn will set the world on fire.

To protect humans from evil yet remain undetected, the Fangborn follow strict rules - but werewolf Jack Parker just keeps breaking them. Failing to disclose his relationship with a Normal could cost him his powers, yet there's something irresistible about waitress Emily Vargas. For one thing, she seems to have no past - at least not one she'll talk about. Jack has kept his affair from the Family but not from his partner, Sully. Lucky for Jack, Sully has more important things to do than report him - like the duo's strange new assignment.

On the surface, Amelia Vernet appears to be the great detective's quiet sixteen-year-old cousin. But her innocent exterior conceals an important fact: Amelia is a member of the Fangborn, a secret family of werewolves, vampires, and oracles sworn to protect Ordinary humans, and she uses her Fangborn werewolf gifts to help Holmes solve the curious cases that cross the doorstep of 221B Baker Street.

When the villagers of Godestone report a series of bizarre and troubling events, Sir Hugo, his heavily pregnant wife, Lady Alice, and her distant kinsman Father Gilbert are honor bound to investigate, for they are “born to the Fang,” shape-shifters dedicated to fighting evil in secret. And the events are worrying indeed - stolen farm implements, a mutilated goat, and now a missing child. Their investigation is further complicated by the arrival of Robert Fynch, who was drawn to the scene by the tales of mysterious happenings in the village.