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The Peptide Podcast

By: The Peptide Queen
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  • Summary

  • The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.
    This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited.
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Episodes
  • The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation

    The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation
    Jun 13 2024
    Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases. In this podcast, we’ll discuss GLP-1’s role in reducing inflammation and how it may help you. What is GLP-1? GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. Here's how glucose-dependent insulin secretion works: Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels. Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1). Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin. Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy. Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels). GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells. The Link Between GLP-1 and Inflammation Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. How does GLP-1 reduce inflammation? Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response. Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body. Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor. Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles. Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs have demonstrated neuroprotective effects by reducing neuroinflammation, improving neuronal survival, and enhancing cognitive function. These benefits are attributed to the reduction in pro-inflammatory cytokines and the enhancement of neurotrophic factors. Therapeutic Implications The anti-inflammatory properties of GLP-1 have significant therapeutic implications. GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, are now being explored for their potential in treating various inflammatory and chronic diseases. Type 2 Diabetes and Metabolic Syndrome: The dual action of GLP-1 in regulating blood glucose and reducing inflammation makes it a promising therapeutic agent for managing type 2 diabetes and its complications. Cardiovascular Diseases: Given the role of inflammation in atherosclerosis and other cardiovascular conditions, GLP-1 analogs could offer cardiovascular protection and improve outcomes in patients with heart disease. Neurodegenerative Disorders: The ...
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    7 mins
  • Differences Among Popular GLP-1 Receptor Agonists for Type 2 Diabetes

    Differences Among Popular GLP-1 Receptor Agonists for Type 2 Diabetes
    Jun 6 2024
    A class of medications known as GLP-1 receptor agonists has revolutionized the treatment of type 2 diabetes and obesity. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion and inhibits glucagon release, helping to regulate blood sugar levels and promote weight loss. In this podcast, we’ll talk about the differences among some of the most well-known GLP-1 receptor agonists for type 2 diabetes. Ozempic (Semaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Primarily for type 2 diabetes (lower blood sugar and A1c); also approved for reducing the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease. Keep in mind, Wegovy (semaglutide) is a higher-dose version that’s approved for weight loss. When you start taking Wegovy or Ozempic, you’ll begin with a low dosage. Your prescriber will increase your dosage every four weeks until you reach the target amount. However, the specific dosage you inject will differ depending on the medication. The maximum dose for Ozempic is 2mg weekly, while the target dose for Wegovy is 2.4mg weekly. Rybelsus (Semaglutide) Form: Oral tablet Dosing Frequency: Once daily Uses: Lower blood sugar and A1c in people with type 2 diabetes. Rybelsus shares the same active ingredient as the injectable medications Ozempic and Wegovy. Ozempic is also approved for Type 2 diabetes, while Wegovy is approved specifically for weight loss. Rybelsus is available in three different strengths: 3 mg, 7 mg, and 14 mg. Similar to Ozempic, the dose is slowly increased every 4 weeks. Good to know: It's important to take Rybelsus first thing in the morning with 4 oz of water. After taking it, you should wait at least 30 minutes before eating, drinking, or taking other medications. Failing to do so may reduce its effectiveness. Currently, Rybelsus is undergoing clinical trials to evaluate its effectiveness for weight loss. The trials involve higher doses than those approved for diabetes treatment. Results indicate that a 50 mg dose of oral semaglutide (Rybelsus) achieves weight loss comparable to Wegovy. Trulicity (Dulaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes; and like Ozempic, it’s also approved for reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Like Ozempic and Rybelsus, you will start at a low dose to help reduce side effects. Your healthcare provider will then gradually increase the dose, balancing the management of side effects with the benefits of blood sugar control. The maximum dose for Trulicity is 4.5mg weekly. Victoza (Liraglutide) Form: Injectable Dosing Frequency: Once daily Uses: Type 2 diabetes; also approved to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Victoza is one of three GLP-1 agonists approved for treating Type 2 diabetes in children aged 10 and older. The other options are Trulicity (dulaglutide) and Bydureon BCise (exenatide). More on this later. Ozempic, however, is only approved for use in adults. Saxenda and Victoza are both injectable medications containing liraglutide, but they are approved for different uses. Saxenda is FDA-approved for chronic weight management in people 12 and older, while Victoza is approved for treating Type 2 diabetes in people 10 and older. Victoza also helps lower the risk of major adverse cardiovascular events in adults with diabetes and heart disease. Both medications are injected once a day, starting with a low dose that is gradually increased over time. The target dose for Saxenda is 3 mg once daily, whereas the maximum dose for Victoza is 1.8 mg once daily. Byetta (Exenatide) Form: Injectable Dosing Frequency: Twice daily Uses: Type 2 diabetes. Additional Benefits: It has a shorter duration of action than other GLP-1 agonists, which may be preferable for some patients. Byetta, approved in 2005, was the first GLP-1 medication of its kind for diabetes. Its active ingredient, exenatide, is a synthetic version of a substance found in Gila monster saliva. The recommended starting dose for Byetta is 5 mcg twice daily, administered within 60 minutes before your morning and evening meals. After one month, your healthcare provider may increase the dose to 10 mcg twice daily. Starting at a lower dose helps reduce stomach-related side effects. Bydureon BCise (Exenatide Extended-Release) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes. Additional Benefits: Extended-release formulation provides a more convenient dosing schedule compared to Byetta. Unlike Byetta, Bydureon BCise has a fixed dose of 2 mg administered once weekly, on the same day each week. It can be taken at any time of day, with or without food. Mounjaro (Tirzepatide) Form: Injectable Dosing Frequency: Once weekly ...
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    10 mins
  • Peptide Therapy to Get Rid of Age Spots

    Peptide Therapy to Get Rid of Age Spots
    May 30 2024
    As you age, you might notice dark or brown spots (hyperpigmentation) appearing on your face, arms, or the tops of your hands. These age spots can also develop on your legs, back, and other parts of your body. Age spots on the face (cheek, chin, nose, forehead, and upper lip) are typically caused by years of exposure to ultraviolet light from the sun (melasma). These age spots are more common in women and those who are pregnant or taking birth control pills. While experts don't know exactly why this is, it's thought that hormones play a role in melasma. Keep in mind that age spots can also be caused by skin injury, such as a cut, burn, or acne breakout. They can also be caused by inflammation, certain medications, and medical conditions such as hypothyroidism, Addison's disease, and certain vitamin deficiencies (B12 or folate). While you can't go back in time to apply more sunscreen and prevent age spots, there are peptide therapies that you can use to fade them. As a refresher, peptides are short chains of amino acids. When used topically, they can penetrate the skin and signal cells to perform specific functions, such as collagen production, skin repair, and pigment regulation. In this podcast, we'll talk about how peptide therapy works to help get rid of the appearance of age spots and what you can expect: How Does Peptide Therapy Work for Age Spots? Inhibition of Melanin Production: Certain peptides can inhibit the activity of tyrosinase, an enzyme crucial for the synthesis of melanin (a dark brown pigment). These peptides help lighten dark spots and even out skin tone by reducing melanin production. Promotion of Skin Renewal: Peptides can stimulate skin cell turnover, promoting the shedding of pigmented cells and the generation of new, healthier skin cells. This helps in fading dark spots over time. Anti-Inflammatory Effects: Peptides can reduce inflammation, which often contributes to hyperpigmentation, especially in conditions like post-inflammatory hyperpigmentation (PIH). Antioxidant Properties: Some peptides have antioxidant properties, protecting the skin from oxidative stress and damage caused by UV radiation, which can exacerbate dark spots. What are Some Common Peptides Used for Treating Dark Spots? Copper Peptides: Known for their wound healing and anti-inflammatory properties, copper peptides can help improve skin texture and reduce pigmentation. Palmitoyl Tetrapeptide-7: This peptide reduces inflammation and promotes the regeneration of new skin cells, helping to diminish dark spots over time. Oligopeptide-68: Specifically designed to reduce hyperpigmentation by inhibiting melanin production and evening out skin tone. Decapeptide-12: Effective in reducing pigmentation and improving overall skin brightness. What are the Benefits of Peptide Therapy for Dark Spots? Targeted Action: Peptides can be formulated to specifically target pigmentation pathways, offering a more precise approach compared to general skin-lightening agents. Minimal Side Effects: Peptides are generally well-tolerated, with a lower risk of irritation and side effects than more aggressive treatments like chemical peels or laser therapy. Multi-functional Benefits: In addition to lightening dark spots, peptides often provide additional skin benefits such as improved texture, firmness, and hydration. Application and Usage of Peptides for Age Spots Topical Serums and Creams: Peptides are commonly found in serums and creams. These should be applied as directed, typically once or twice daily, after cleansing and before moisturizing. Consistency is Key: Peptide therapy results can take several weeks to become noticeable. Consistent use is crucial for achieving the best results. Sun Protection: Peptides used to treat dark spots should be paired with effective sun protection. Sunscreen helps prevent further pigmentation and supports the action of peptides. As a general rule, make sure to choose sunscreen that is broad-spectrum (protects against UVA and UVB rays), SPF 30 (or higher), and water-resistant. If you are considering peptide therapy for dark spots, it's recommended to consult with a dermatologist to determine the most suitable peptides for your skin type and condition. Often, combining adequate sunscreen, prescription medications, peptide therapy, and certain procedures such as microdermabrasion, lasers, and chemical peels may be needed. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by ...
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    6 mins
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