Episodios

  • Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322

    Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322
    Sep 2 2025
    Millions of people are living with unexplained symptoms like allergies, brain fog, anxiety, and chronic fatigue without realizing the hidden cause: mast cells gone rogue. In this episode of The Human Upgrade, Host Dave Asprey sits down with leading functional medicine physician Dr. Tania Dempsey to uncover how Mast Cell Activation Syndrome (MCAS) drives inflammation, disrupts mitochondria, and sabotages metabolism—and what you can do to switch it off. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Dempsey is internationally recognized for her work in functional medicine, biohacking, and chronic illness. She co-founded the AIM Center for Personalized Medicine, has published groundbreaking research on MCAS with Dr. Lawrence Afrin, and treats some of the most complex cases of immune dysregulation, autoimmune disease, and environmental illness. Her expertise helps you understand why mast cells are the missing link in allergies, long COVID, Lyme, mold toxicity, and even hormone disruption—and how to reclaim control of your biology. Dave and Dr. Dempsey break down how mast cells interact with mitochondria, hormones, and the nervous system, showing how chronic inflammation accelerates aging and blocks human performance. You’ll discover why biohacking tools like fasting, ketosis, supplements, red light, cold therapy, sleep optimization, and smarter not harder lifestyle strategies all influence mast cell stability. They also explore why brain optimization, neuroplasticity, and nootropics are essential for calming inflammatory cascades, and how functional medicine provides practical solutions beyond conventional treatment. You’ll Learn: • Why mast cells are the hidden switch behind allergies, chronic inflammation, and brain fog • How mitochondria and mast cells work together to drive human performance—or disease • The connection between toxic mold, Lyme, long COVID, hormone imbalance, and MCAS • How supplements, fasting, ketosis, and cold therapy stabilize mast cells and boost longevity • Why functional medicine and biohacking are essential for complex chronic illness • How mast cells impact metabolism, sleep optimization, and neuroplasticity • The surprising link between mast cells, anxiety, and mental health symptoms This episode is essential for anyone serious about hacking inflammation, protecting longevity, upgrading metabolism, and achieving high performance with resilience and clarity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: mast cell activation syndrome, MCAS, chronic inflammation, mitochondria dysfunction, histamine intolerance, functional medicine, biohacking, allergies, brain fog, long covid, mold toxicity, Bartonella, Lyme co-infections, oxalates, salicylates, mast cell stabilizers, immune dysregulation, neuroinflammation, chronic fatigue syndrome, autoimmune triggers, personalized medicine, longevity supplements Thank you to our sponsors!Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.Resources: • Tania’s Website: https://drtaniadempsey.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:10 — Introduction 03:27 — Why So Sick Today? 05:57 — MCAS Explained 08:33 — Mold & Environment 11:36 — Spotting MCAS 13:43 — Personal Stories 15:15 — Research & Biohacking 16:35 — Managing Triggers 20:15 — Gut & Stomach Acid 22:42 — Reaction Timing 25:30 — Hormones & MCAS 28:39 — Thyroid & Mitochondria 32:28 — Chronic Illness Navigation 40:06 — Insurance Battles 44:44 — Cholesterol & Ethics 49:11 — Personalized Care 53:24 — Circadian & Stress 58:24 — Testing Approaches 01:01:35 — Collagen & Joints 01:04:34 — MMPs & Aging 01:09:12 — Access & Experimentation 01:13:14 — MCAS & Mental Health 01:17:46 — Benzos & Stigma 01:...
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    1 h y 29 m
  • What Is Uric Acid and How Does It Predict Your Longevity : 1321

    What Is Uric Acid and How Does It Predict Your Longevity : 1321
    Aug 29 2025
    Most people track glucose or ketones, but almost no one is measuring the hidden signal that could be silently wrecking your metabolism, brain function, and longevity: uric acid. This episode reveals why this overlooked biomarker drives obesity, diabetes, cardiovascular disease, Alzheimer’s, and even accelerated aging—and how you can hack it to unlock resilience, human performance, and smarter not harder health upgrades. Watch the podcast on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR We revisit host Dave Asprey sitting down with Dr. David Perlmutter, one of the world’s leading functional medicine neurologists and the #1 New York Times bestselling author of Grain Brain and Drop Acid. Dr. Perlmutter has spent decades connecting gut health, brain optimization, and neuroplasticity with lifestyle interventions that truly change the trajectory of disease. In this conversation, he explains how uric acid acts as a metabolic switch that determines whether you burn fat or store it, whether your mitochondria power you up or slow you down, and whether your brain stays sharp or declines with age. They break down how fructose, purines, alcohol, and even dehydration spike uric acid, why Japan is decades ahead in using this as a health marker, and how supplements like quercetin and luteolin rival pharmaceuticals in keeping it under control. You’ll also learn how ketosis, fasting, cold therapy, carnivore and plant-based approaches, and sleep optimization all interact with uric acid to shape your healthspan. This is biohacking at its most actionable—because once you measure this signal, you can control it, and once you control it, you radically upgrade your metabolism, your brain, and your longevity. This is essential listening for anyone serious about hacking their biology, building neuroplasticity, powering up mitochondria, exploring nootropics, and discovering smarter not harder ways to live longer and perform better. You’ll Learn: • Why uric acid may be the most important overlooked biomarker for longevity • How it connects obesity, diabetes, cardiovascular disease, and Alzheimer’s • The evolutionary reason your body uses uric acid as a survival signal • How fructose and hidden sugars sabotage metabolism and brain optimization • The role of quercetin, luteolin, and targeted supplements in lowering uric acid • Why measuring at home with a simple device can change your health trajectory • How functional medicine uses uric acid as a predictive tool for chronic disease Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: uric acid longevity, uric acid metabolism, fructose uric acid pathway, xanthine oxidase inhibition, quercetin uric acid, luteolin supplements, AMP kinase uric acid, AMP deaminase metabolism, uric acid and mitochondria, uric acid and neuroplasticity, uric acid Alzheimer’s risk, uric acid dementia prevention, uric acid and nitric oxide, fructose metabolism hibernation biology, evolutionary mismatch uricase mutation, fructokinase inhibition, uric acid and insulin resistance, gout biohacking, uric acid and obesity, uric acid functional medicine Resources: • David’s Website: https://drperlmutter.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 0:35 — Introduction 2:26 — Why Uric Acid Matters 5:55 — Measuring Uric Acid 8:17 — Disease Risk 9:38 — Metabolism Disruption 15:59 — What Raises Uric Acid 26:20 — Global Research 29:50 — Gut & Inflammation 32:55 — Seasonal Eating 47:36 — Brain Health 56:38 — Supplements & Testing 61:45 — The LUV Diet 71:41 — Closing Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    1 h y 10 m
  • Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320

    Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320
    Aug 28 2025
    Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You’ll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anna Lembke, Stanford psychiatrist and bestselling author of Dopamine Nation. She is one of the world’s leading experts on addiction, compulsive behavior, and the neuroscience of reward pathways. With decades of clinical work and groundbreaking research, she explains why dopamine has become the modern lens for understanding desire, distraction, and dysfunction—and how we can hack it to upgrade human performance. They break down how dopamine drives addiction, why pain can reset your reward system, and how simple practices like fasting, cold therapy, and supplements affect your brain chemistry. You’ll learn how nicotine, GLP-1 drugs, and even nootropics alter dopamine sensitivity, and why overstimulation from social media, pornography, and ultra-processed food is creating an epidemic of anhedonia. The conversation also covers how functional medicine and biohacking can protect your mitochondria, restore your natural dopamine balance, and make your brain more resilient. You’ll Learn: • Why dopamine itself is not addictive—and what really drives addiction • How pain, hormesis, and “dopamine fasting” can reset your reward system • Why social media and digital overstimulation create chronic dopamine deficit states • The role of GLP-1 drugs, nicotine, psychedelics, and other substances in rewiring dopamine • How functional medicine and supplements help restore dopamine balance • The connection between dopamine, mitochondria, fasting, cold therapy, and longevity • Why radical honesty and self-binding are powerful anti-addiction hacks This is essential listening for anyone serious about hacking dopamine for better focus, sleep optimization, metabolism, and long-term brain health. Whether you’re curious about the link between dopamine and neuroplasticity, looking to upgrade human performance with smarter not harder tools, or just want to know how to stop dopamine hijacks from ruling your life, this episode gives you the science and strategies you need. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: dopamine fasting, pleasure-pain balance, dopamine deficit state, addiction neurobiology, anhedonia treatment, dopamine receptors, neuroadaptation gremlins, endogenous opioids, cold plunge dopamine, hormesis neuroscience, nucleus accumbens dopamine, L-Dopa addiction, GLP-1 and dopamine, social media addiction neuroscience, dopamine reward pathway, compulsive behavior psychiatry, dopamine and neuroplasticity, anhedonia supplements, functional medicine addiction, dopamine repair party Thank you to our sponsors! Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Anna’s Website: https://www.annalembke.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 5:47 — Pleasure–Pain Balance 6:45 — Homeostasis & Adaptation 8:22 — Addiction & Dopamine Deficit 10:14 — BICEP: Conscious Pain Exposure 14:26 — Adapting to Pleasure & Pain 20:20 — GLP-1s and Joy 21:39 — Modern Anhedonia 34:32 — Resilience in Young People 42:00 — Social Media & Mental Health 44:46 — Control & Addiction 55:14 — Dopamine Fasting 1:03:18 — Self-Binding Tools 1:07:56 — Psychedelics & Addiction 1:12:25 — ...
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    1 h y 15 m
  • You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319

    You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319
    Aug 26 2025
    Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer’s is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You’ll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You’ll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You’ll Learn: • Why Alzheimer’s can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer’s and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer’s prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer’s, Paraquat Parkinson’s risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer’s, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale’s Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson’s, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison’s...
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    1 h y 47 m
  • The Hormone War Dividing Female and Male Longevity : 1318

    The Hormone War Dividing Female and Male Longevity : 1318
    Aug 22 2025
    Your hormones may be waging a hidden war that determines how long you live and how well you perform. This episode reveals how male and female biology diverge—and what those differences mean for your longevity, metabolism, and brain optimization. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Revisit this episode where Dave Asprey sits down with Teal Swan, a bestselling author and international speaker known for her work on human behavior, healing, and consciousness. Her insights bridge biology and psychology, uncovering how hormones, trauma, and environment shape both performance and resilience. Her ability to decode patterns of narcissism, victimhood, and trust through the lens of functional medicine and human performance makes her one of the most provocative voices in personal transformation. Together, they explore the science behind the hormonal divide between men and women—why birth control alters not just fertility but also male testosterone, why perception and neurodivergence impact neuroplasticity, and how early trauma imprints mitochondria and metabolism. You’ll learn how fasting, ketosis, cold therapy, sleep optimization, and smarter not harder strategies can shift your biology toward higher resilience and greater longevity. They also break down the biohacking tools and supplements that can help balance hormones, upgrade mitochondria, and fuel nootropics-level brain performance. From the hidden biological costs of hormonal birth control to how carnivore and targeted nutrition affect both male and female healthspan, this episode gives you a framework for hacking your biology at the deepest level. This is essential listening for anyone serious about biohacking, hacking human performance, brain optimization, functional medicine, or understanding how masculine and feminine biology directly influence lifespan and resilience. You’ll Learn: • How hormonal birth control impacts both women’s fertility and men’s testosterone • Why victim mentality rewires the brain and reduces neuroplasticity • How narcissism functions as a biological stress adaptation • The role of mitochondria, metabolism, and trauma in shaping healthspan • How fasting, ketosis, supplements, and cold therapy affect hormone balance • Why balancing male and female energetics may be a key to longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: hormone war, male vs female longevity, hormonal birth control effects, testosterone collapse, estrogen disruption, masculine vs feminine biology, victim mindset neuroscience, narcissism as adaptation, betrayal and biology, neuroplasticity and trauma, perception and neurodivergence, fractal vision, birth trauma programming, mitochondria and stress, species-level hormone imbalance, industrial hormone disruption, male fertility decline, female hormone resilience, functional medicine hormones Resources: • Teals Website: https://tealswan.com/ • Teal’s YouTube: https://www.youtube.com/@TealSwanOfficial • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Cold Open 0:33 — Intro 2:49 — Defining Narcissism 5:48 — Gender Differences in Narcissism 7:47 — AI, Humanity, and the Future 10:25 — Extrasensory Perception & Childhood Experiences 14:04 — Birth Memories and Early Trauma 17:57 — Spiritual Abilities and Neurodivergence 22:48 — Functioning in the World with Unique Perceptions 23:45 — Trust, Support, and Creation 30:07 — Ego, Consciousness, and Spiritual Guides 33:46 — Dimensions and Multiverse Concepts 36:52 — Divine Masculine & Feminine 40:25 — Societal Imbalances and Gender Energies 46:20 — Hope for Humanity & Utopia 48:36 — Synchronization Workshops & Group Healing 51:30 — Science, Energy, and Invisible Communication 53:29 — Conclusion & Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at ...
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    54 m
  • The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317

    The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317
    Aug 21 2025
    Walking speed predicts your risk of death better than cholesterol—and this episode reveals why. You’ll learn how to test your biological age at home in just 10 seconds, and how to use that information to upgrade your human performance, extend your longevity, and tailor your biohacking strategy for maximum results. Discover the overlooked role of pelvic floor strength, glute activation, and neuromuscular training in brain optimization, metabolism, and injury prevention. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey speaks with Dr. Vonda Wright, a double board-certified orthopedic surgeon, hormone optimization expert, and elite sports medicine pioneer who’s worked with Olympic athletes, military special forces, and high-performing women through every phase of life. With decades of experience in functional medicine, movement science, and hormone therapy, Dr. Wright shares the essential strategies to prevent frailty, rebuild strength, and thrive through perimenopause and beyond. You’ll learn: • How walking speed reveals aging and longevity better than traditional blood tests • The biomechanics behind muscle “shutdown” and how to turn muscles back on • The truth about C-sections, pelvic floor rehab, and functional motion assessments • Which supplements, nootropics, and hormone therapies restore metabolism and vitality • Why perimenopause is a turning point for brain, bone, and cardiovascular health • Testing tools and training methods to upgrade strength, prevent falls, and age powerfully Whether you want to feel stronger, think sharper, or stay youthful into your 90s, this is your roadmap for smarter not harder biohacking with real-world impact. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: 10-second walk test longevity, pelvic floor dysfunction and aging, glute activation for brain health, perimenopause hormone replacement therapy, VO2 max biohacking, estrogen for bone density, neuromuscular reactivation exercises, functional movement assessment AI, post-C-section core recovery, velocity training for longevity, strength vs muscle mass aging, menopause testosterone therapy, mitochondrial health for women, sleep optimization progesterone, cold therapy for muscle recovery, fascia training for anti-aging, diastasis recti long-term effects, smart exercise hacks for aging, hormone optimization for libido and brain, smarter not harder fitness protocols Thank you to our sponsors! Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Resources: • Vonda's Website: https://www.drvondawright.com/ • Vonda's Instagram: https://www.instagram.com/drvondawright/?hl=en • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer1:23 — Intro2:55 — Muscle Atrophy and Reactivation6:10 — Pelvic Floor Health and Rehab8:47 — Joint Mobility and Movement10:02 — Science of Muscle Function18:23 — Perimenopause and Menolescence27:58 — Four Essential Female Hormones42:50 — VO2 Max and Longevity49:24 — Velocity Training and Bone Health62:30 — Turning Menopause into Power65:58 — Closing Thoughts and Book Rec See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    1 h y 7 m
  • PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316

    PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316
    Aug 19 2025
    Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You’ll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You’ll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You’ll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25’ for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD’s Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium’s Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    1 h y 8 m
  • Still Fasting in 2025? Here’s How to Make It Work Better : 1315

    Still Fasting in 2025? Here’s How to Make It Work Better : 1315
    Aug 15 2025
    How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN. Christian’s decades of research have transformed our understanding of how stem cells repair the body, reverse damage, and amplify performance. He shares practical protocols to mobilize stem cells, improve microcirculation, and reduce inflammation so your body heals faster, functions better, and stays younger for longer. You’ll learn: • How stem cells rebuild muscle, brain, and organ tissue for optimal human performance • Why fasting rejuvenates bone marrow and increases stem cell effectiveness • The synergy between PEMF, vibration therapy, cold therapy, and stem cell activation • How microcirculation and inflammation control improve longevity and recovery • The best supplements and nutrients to support mitochondria and stem cell health • How to stack nootropics, ketosis, and brain optimization tools for lasting energy and focus This is essential listening for anyone serious about biohacking, longevity, human performance, mitochondria health, neuroplasticity, functional medicine, fasting protocols, supplements for recovery, brain optimization, smarter not harder healing, metabolism upgrades, cold therapy stacks, and next-level physical and cognitive resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: STEMREGEN, biohacking, natural stem cell activation, human performance, longevity, mitochondria, neuroplasticity, fasting, bone marrow rejuvenation, functional medicine, supplements, brain optimization, metabolism, cold therapy, microcirculation, nootropics, ketosis, smarter not harder, recovery hacks Resources: • STEMREGEN Website: https://www.stemregen.co/dave for 20% off your first order. • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:00 — Why Some People Regenerate Better 1:52 — Testing Stem Cell Levels 2:58 — Natural Stem Cell Function 3:59 — Exercise & Stem Cell Response 5:13 — Tissue Turnover & Regeneration 7:03 — Bone Marrow Production 8:16 — Fasting & Bone Marrow 9:33 — Nutrition for Bone Marrow 11:14 — Traditional Meets Modern Science 12:58 — Training Bone Marrow 13:57 — Stem Cells as Repair System 34:20 — Stem Cells & Brain Injury 47:01 — Inside STEMREGEN Products 55:41 — Stress, Cortisol & Stem Cells 58:12 — Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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