The Health Edge: translating the science of self-care Podcast Por Mark Pettus MD and John Bagnulo PhD MPH arte de portada

The Health Edge: translating the science of self-care

The Health Edge: translating the science of self-care

De: Mark Pettus MD and John Bagnulo PhD MPH
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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.

Will Rogers


We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.

We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.

Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.

Mark and John

© 2025 The Health Edge: translating the science of self-care
Enfermedades Físicas Higiene y Vida Saludable Medicina Alternativa y Complementaria
Episodios
  • Coffee, AFib, And What The Science Says
    Dec 11 2025

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    Coffee and heart rhythm don’t have to be enemies. We dig into a new randomized trial across the US, Canada, and Australia suggesting that caffeinated coffee may lower the risk of recurrent atrial fibrillation compared with abstaining, then connect the dots with real-world monitoring, ablation strategy, and day-to-day choices that influence heart health.

    We start by grounding AFib in plain terms: what it is, why so many people never feel it, and how stroke risk rises when the atria stop driving a steady beat. From there, we step into the electrophysiology lab to explain why trouble often starts near the pulmonary veins and how clinicians map and ablate rogue electrical tissue. Along the way, we highlight the role of wearables like Apple Watch in catching silent arrhythmias and guiding decisions, a shift that is rapidly improving detection and management outside the clinic.

    Then we unpack the DECAF trial’s headline: coffee drinkers showed meaningfully lower recurrence of AFib or flutter over six months versus those who abstained. We explore possible reasons, from caffeine’s adenosine receptor antagonism and calcium signaling effects to the antioxidant and mitochondrial support offered by coffee’s polyphenols. We also compare with NEJM data in the general population showing no significant increase in ectopy, putting fears into perspective. Finally, we get practical: dosing and timing to protect sleep, what brewing methods change, how dairy proteins can blunt polyphenol absorption, and when unfiltered versus filtered makes sense if you’re balancing lipids and antioxidants.

    If you enjoy coffee and live with AFib, these insights can help you personalize your cup without losing sight of the fundamentals: anticoagulation when indicated, smart rate or rhythm control, and balanced training that avoids chronic overload. If this conversation helps you think differently about caffeine, subscribe, share with someone who cares about heart health, and leave a review so others can find it.

    For powerpoint slide deck, video recording and reference open-source articles go to: www.thehealthedgepodcast.com

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    35 m
  • The Delicate Balance Between Oxidative Stress And Antioxidants
    Dec 3 2025

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    Most wellness advice tries to stamp out oxidative stress. We make a different case: the right dose of stress is the signal that builds resilience. From the first snowfall chat to a deep dive on electrons, mitochondria, and energy flow, we walk through how redox balance—reduction and oxidation—is the unseen driver of better fitness, metabolism, and healthy aging. Rather than drowning your cells in pharmacologic antioxidant doses, we show why whole foods, intelligent training, and hormetic practices switch on the body’s superior, built-in defenses.

    We break down how reactive oxygen species act as messengers that activate NRF2 and tune NF kappa B, leading to stronger antioxidant enzymes like superoxide dismutase, catalase, and glutathione. You’ll hear why studies on high-dose vitamin A, E, and isolated polyphenols have disappointed or even backfired, and how funding bias confuses the supplement hype cycles. We connect these insights to practical levers: balancing training intensity to avoid chronic overreach, using time-restricted eating to spur ketone-driven repair, and introducing sauna, cold exposure, and real daylight to enhance mitochondrial function and recovery.

    Food-first takes center stage. We discuss the risks of seed oils and excessive polyunsaturated fats on membrane stability and oxidative load, plus simple swaps toward olive oil, avocado, and nutrient-dense whole foods. Micronutrients like selenium, zinc, and sulfur amino acids matter because they power your endogenous antioxidant systems. The goal isn’t to smother the flame; it’s to keep a steady candle that signals adaptation without tipping into a wildfire. We close with a n=1 approach—listen to energy, sleep, and training feedback—and small experiments that reveal your best balance.

    If this resonated, follow the show, share it with a friend who loves the science of training and longevity, and leave a quick review so more listeners can find us.

    For video, open access reference papers and PP slide deck go to: www.thehealthedgepodcast.com

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    52 m
  • How To Love Holiday Food That Loves You Back
    Nov 26 2025

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    The table can be joyful and nourishing at the same time. We open the season with a simple promise: keep the flavors you love, swap the parts that don’t love you back. From a resistant starch gravy that boosts your microbiome to a mushroom-forward, breadless stuffing that hits all the nostalgic notes, we map a path to a Thanksgiving that tastes great and leaves you energized.

    We rethink side dishes through a health-first lens without losing comfort: slow-roasted sweet potatoes finished with cinnamon for better glycemic control, and an antioxidant-rich spotlight on purple sweet potatoes that bring deep color and deeper benefits. For greens, Brussels sprouts or collard greens deliver sulforaphane for brain, liver, and heart support—just don’t overcook them. Along the way we break a holiday myth: the “turkey coma” usually comes from sugary sides, not tryptophan. Make protein your anchor for satiety, stable energy, and fewer dessert cravings.

    Dessert still gets its moment. A pumpkin pie with a pecan or almond crust shifts the macro balance to healthy fats and fiber, pairs perfectly with warm spices, and can be lightly sweetened with monk fruit or stevia without the aftertaste. We also talk liver-friendly choices: why alcohol collides with fructose and omega-6 seed oils, and how a few tweaks protect metabolic health during a season of abundance. If you use a continuous glucose monitor, this is the perfect time to experiment and learn—no guilt, just data that helps you feel better.

    Pull up a chair with gratitude, savor the company, and cook in a way that makes tomorrow brighter. If this guide helps you plan your feast, tap follow, share it with a friend, and leave a quick review to help others find the show.

    www.thehealthedgepodcast.com

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    29 m
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