Is a big prostate really dangerous? Does it mean prostate cancer—or explain why you’re waking up at night to urinate? Not always.

In this upgraded replay, Dr. Geo breaks down the real story behind prostate enlargement why size isn’t always the issue, how bladder and nerve health factor in, and what questions to ask your doctor before starting medication or considering surgery.

🎯 You’ll Learn

✅ Why prostate size isn’t always the cause of urinary problems


✅ How the bladder and nerves affect flow and frequency


✅ When drugs like Finasteride and Dutasteride are unnecessary


✅ Why an enlarged prostate ≠ prostate cancer


✅ Smart testing options to avoid unnecessary biopsies

⏱ Chapters

00:00 Introduction — How dangerous is an enlarged prostate?


00:45 Normal vs Enlarged Prostate — Walnut vs Orange size explained


01:20 When Size Doesn’t Matter — Obstruction without enlargement


02:00 The Morning Stream Myth — Why slow flow at dawn isn’t always serious


03:00 Bladder-Prostate Synergy — The teamwork behind healthy urination


04:15 Medication Pitfalls — Finasteride & Dutasteride explained


05:30 Hair Loss & Hormones — Side effects of prostate drugs


06:00 Enlarged Prostate ≠ Cancer — Clearing up the myth


07:00 When It Can Be a Problem — Nerve compression & PAE treatment


08:00 Smarter Testing — ExoDx urine test vs PSA


08:45 Questions to Ask Your Urologist


09:30 Closing Thoughts — Live stronger, longer, and better

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📣 Hashtags

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⚠️ Disclaimer

This episode is for educational purposes only and not medical advice. Always consult with a qualified healthcare provider. Geovanni Espinosa, N.D., assumes no liability for outcomes based on this content.

Dr. Geo speaks with cancer immunologist Matthew Halpert, PhD about Immunocine, a dendritic-cell platform that “double-loads” patient-specific tumor signals to trigger a strong, physiologic immune response. Discussion includes mechanism, prostate cancer cases, how it can complement ADT and focal radiation, eligibility, workflow, and access.

Chapters

00:00 How the Immune System Fights Prostate Cancer

02:00 Why dendritic cells matter; generals vs NK/T “soldiers”

07:00 The “double-loading” breakthrough and fail-safe concept

14:00 Trials in difficult cancers; safety and early signals

18:00 Prostate cases: CRPC responses; lesions regressing

22:00 Combining with ADT and focal radiation; timing

27:00 Critical need for viable tissue; preservation tips

34:00 Patient journey: review → tissue + apheresis → 3 doses/6 weeks

41:00 Peri-lymphatic delivery; what patients feel; follow-up/boosts

49:00 Cost, access, insurance help; foundations; closing takeaways

Key Takeaways

• Dendritic cells orchestrate immunity; NK/T cells execute.
• Precision double-loading overcomes a built-in fail-safe to amplify activation.
• Tissue access and preservation are essential for a broad, personalized target set.
• Pragmatic combination care: ADT and selective radiation can create a therapeutic window and enhance antigen presentation.

________________________

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💪 Exclusive Membership

Unlock curated transcripts, detailed show notes, expert resources, and perks.

Join here → https://drgeo.com/membership

📌 Follow and Connect

YouTube → https://www.youtube.com/@DrGeoProstatePodcast

All Podcast Episodes → https://dr-geo-prostate-podcast.captivate.fm

Instagram → https://bit.ly/DRGEO-INSTA-YT

Facebook → https://bit.ly/POD-FB-DrGeo

LinkedIn → https://bit.ly/DRGEO-LINKEDIN-YT

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Website → https://bit.ly/43khht0

📣 Hashtags

#DrGeoProstatePodcast #ProstateCancer #ProstateHealth #MensHealth #IntegrativeUrology #SBRT #Oligometastatic #RadiationOncology #PSMAPET #ADT

⚠️ Disclaimer

This episode is for educational purposes only and not medical advice. Always consult with a qualified healthcare provider. Geovanni Espinosa, N.D., assumes no liability for outcomes based on this content.

AI has existed for decades, but modern deep learning is finally delivering precision decisions in clinic. Dr. Spratt details how ArteraAI’s predictive biomarker—validated on long-term randomized data—can spare roughly two-thirds of eligible men from ADT without compromising outcomes. We unpack ADT’s quality-of-life trade-offs, practical training and nutrition strategies to preserve muscle, and where AI is headed next (post-surgery models, higher-risk disease). You’ll also hear a clear framework for shared decision-making so men are treated as people, not just numbers.

✅ AI meets prostate cancer. ArteraAI, developed by Dr. Daniel Spratt’s team, is now part of the NCCN guidelines—helping doctors know which patients truly benefit from hormone therapy.

✅ Two-thirds can skip ADT. Long-term data from the RTOG 9408 trial show most men can avoid the side effects of hormone therapy without affecting outcomes.

✅ Quality of life first. Treatments should improve survival or well-being—if they don’t, they shouldn’t be used.

✅ Lifestyle still matters. Exercise, protein, and resistance training help men on ADT preserve muscle and energy.

✅ The future is personalized. New AI models will soon guide therapy for higher-risk patients and integrate full-body health data for truly tailored care.

• 00:00 – Why AI in prostate cancer now? From buzzword to bedside with ArteraAI.
• 01:30 – Deep learning vs. “human-defined” inputs; beyond Gleason to hundreds of slide features.
• 03:10 – Landmark validation: RTOG 9408 and how the model predicts who benefits from ADT.
• 05:00 – ADT trade-offs: longevity vs. libido, energy, bone/muscle; treat only if it improves life or survival.
• 07:15 – “Exercise is medicine”: the 10-minute rule, protein targets, and resistance training on ADT.
• 09:00 – Current indication: primarily intermediate-risk (Gleason 7) men receiving radiation.
• 10:45 – What’s next: models for higher-risk and post-prostatectomy patients; shorter-course ADT questions.
• 13:00 – “Black box” & explainability: why robust external validation matters for trust.
• 15:10 – Access & coverage: ordering via online portal; CMS coverage; what patients can ask their doctors.
• 17:20 – Shared decision-making: reduce PSA anxiety; treat the person, not the number.

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