What if prostate cancer treatment weren’t months of daily radiation—but five ultra-precise sessions guided in real time by MRI? Today, Dr. Michael J. Zelefsky (Professor of Radiation Oncology, NYU Grossman School of Medicine) explains how MRI-LINAC and adaptive planning are redefining accuracy, reducing side effects, and personalizing care. A pioneer behind IMRT and image-guided radiotherapy, Dr. Zelefsky breaks down SBRT vs. IMRT, protons vs. photons, HDR brachytherapy, when to add hormone therapy, and how genomics + AI are shaping what’s next.

In this conversation, Dr. Zelefsky charts the evolution from long-course radiation to short-course SBRT with outcomes comparable to 7–9 week regimens—thanks to precision imaging and planning. He clarifies where IMRT ends and SBRT begins, why protons haven’t shown superiority over photons in prostate cancer, and where HDR brachytherapy (Ir-192) shines—especially as a boost in higher-risk disease. We dig into dose equivalence (why 5×8 Gy can match ~80–90 Gy long-course), risk-based treatment + ADT duration, and how Decipher/Artera scores can refine decisions. Most exciting: MRI-LINAC with continuous motion monitoring keeps the prostate in a virtual “bullseye,” enabling whole-gland treatment with focal boosts today—and potentially true focal therapy tomorrow as biologic imaging and AI mature.

Time-Stamped Highlights

00:00 – Welcome

02:00 – Why Dr. Zelefsky’s work is so respected; career arc and impact

04:00 – What changed: CT/MRI planning → 3D-CRT → IMRT → SBRT

12:45 – IMRT vs. SBRT: definitions, session counts, who gets what

19:10 – Energy sources overview: photons, protons, brachytherapy

20:30 – Protons vs. photons: evidence, indications, cost, access

24:00 – HDR brachytherapy (Ir-192) as a temporary “in-and-out” boost

28:00 – Dose logic: why 5×8 Gy (~40 Gy) ≈ long-course 80–90 Gy

29:30 – Risk groups (low/intermediate/high) and when ADT is crucial

33:00 – ADT durations (6–36 months): what trials actually showed

37:00 – Genomics (Decipher/Artera): resolving risk discrepancies

39:00 – What MRI-LINAC adds: real-time adaptive planning

43:00 – Continuous Motion Monitoring (CMM): beam stops if target moves

47:00 – Treat whole gland + boost the DIL (FLAME study approach)

49:00 – Toward focal therapy with better biologic imaging + AI

54:00 – How to choose: values, side-effects, lifestyle, comorbidities

01:01:00 – Final guidance: don’t be overwhelmed—multiple good option

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⚠️ Disclaimer

This podcast is for educational purposes only and not medical advice. The views expressed are Dr. Geo’s and not those of his employer(s) or affiliated organizations. Use of this content is at your own

HIFU (high-intensity focused ultrasound) is one of the most talked-about focal therapies in prostate cancer—but who is it really right for? In this conversation, Dr. Matthew Cooperberg (UCSF)—a leading voice in urology, epidemiology, and integrative prostate cancer care—breaks down patient selection vs. energy modality, how modern imaging (MRI, fusion, RSI) drives precision, what genomics (e.g., Decipher) can and can’t tell us, and how salvage options compare after focal therapy vs. radiation. We also tackle lifestyle factors, trial design, and why midlife PSA screening (ideally <1 between ages 45–55) remains crucial.

👉 View more at DrGeo.com

00:00 – Welcome + episode setup (HIFU overview, aims of focal therapy)

04:10 – The real first question: Who is a candidate? (selection > modality)

05:10 – What “focal therapy” means (lesion-only, margin, hemi-ablation) + imaging progress

06:25 – Recurrence after focal therapy: targeting, dose, or biology? Follow-up biopsies

07:40 – Genomics (Decipher): predicting recurrence; how results change counseling

09:30 – Lifestyle & microenvironment: can diet/exercise influence outcomes?

11:00 – Salvage after focal vs. radiation: fibrosis, feasibility, quality of life

14:00 – Cryotherapy vs. HIFU: image guidance, control, and why HIFU advanced

16:00 – Imaging upgrades (MRI fusion, RSI, C-13 spectroscopy) and treatment constraints

17:00 – IRE (irreversible electroporation): role for apical tumors, early results

18:00 – TULSA, water/thermal concepts, focal radiation, partial prostatectomy: what’s known

20:00 – Smarter trials: active surveillance ± focal therapy for borderline cases

22:00 – The counseling hierarchy: decision first, technology second

24:30 – Proton vs. photon incentives; why advertising confuses choices

26:30 – UCSF’s program: mostly HIFU; where IRE fits; adding new machines prudently

28:30 – The real bottleneck: sub-millimeter targeting; AI-guided ablation future

33:00 – HIFU mechanics: probe size, apex/anterior reach, distance constraints

35:00 – “I want HIFU for Gleason 8”: agency, nuance, and when we advise against it

38:00 – A cautionary case: negative biopsy → later mets—what it teaches us

40:30 – Millennials, risk tolerance, and why PSA at 45–55 (<1 is ideal) matters

44:00 – Growth vs. spread: which high-grade tumors can we treat focally?

46:00 – How low vs. high genomic scores tilt decisions (and their limits)

47:30 – Where to find Dr. Cooperberg + parting PSA advice

___________________________________

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___________________________________

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Can high-dose IV Vitamin C really support cancer treatment—even in men with prostate cancer? In this episode of the Dr. Geo Prostate Podcast, Dr. Geo welcomes Dr. Paul Anderson, one of the world’s leading voices in integrative oncology with 30+ years of clinical experience and NIH-funded cancer research.

Together, they unpack how vitamin C works differently when taken orally versus intravenously, what the latest research shows about IV vitamin C, and how it may impact the tumor microenvironment and immune response.

Listeners will also learn about practical approaches to integrative oncology, the role of detoxification and immune health, and what patients with advanced prostate cancer should know before seeking out IV vitamin C therapy.

✅ What You’ll Learn in This Episode:

• How oral vs. IV vitamin C behave differently in the body
• What the latest science says about IV vitamin C in cancer care
• Why the tumor microenvironment matters for long-term outcomes
• How IV vitamin C may support men with advanced prostate cancer
• Synergies with lifestyle therapies, immunotherapy, and sauna

💡 Don’t forget to subscribe, rate, and review the podcast! Every review helps us reach more men who want to thrive, not just survive.

_________________________

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ProLon 5-Day Fasting Mimicking Diet — Enjoy fasting benefits with food. Supports cellular renewal, metabolic health, and fat loss. Special offer for our listeners: Get the ProLon kit for $148 → https://bit.ly/3TVehAx

AG1 by Athletic Greens — 75 high-quality vitamins, minerals, probiotics, and adaptogens in one daily scoop. Supports gut health, immunity, energy, and focus. Try it here → https://bit.ly/3mA2tVV

💪 Exclusive Membership

Want deeper insights? Join The Dr. Geo Prostate Podcast Exclusive Membership for curated transcripts, detailed show notes, expert resources, and member perks. → https://drgeo.com/membership

📌 Follow and Connect

📺 YouTube → Dr. Geo Prostate Podcast / @drgeoprostatepodcast

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_________________________

⚠️ Disclaimer: This podcast is educational and not medical advice. Always consult your healthcare provider before making changes to your treatment.

In this inspiring episode of the Dr. Geo Prostate Podcast, Dr. Geo sits down with Dr. Amy Rothenberg — a licensed naturopathic doctor for over 36 years, 2017 Physician of the Year by the American Association of Naturopathic Physicians, and a living example of resilience.

After 18 rounds of chemotherapy in 2014, Dr. Rothenberg competed in her first triathlon just six months later. She shares her journey of overcoming breast, ovarian, and leukemia diagnoses while integrating both conventional and naturopathic medicine. Her best-selling book, You Finished Treatment, Now What?, offers cancer survivors a compassionate, practical roadmap to reclaim their health.

Whether you’re living with cancer, supporting someone who is, or looking for ways to live better with age, this conversation is filled with actionable insights on healing, prevention, and thriving.

Key Points:

• A Doctor Becomes the Patient – How Dr. Rothenberg faced multiple cancer diagnoses and treatments while maintaining her health philosophy.
• Integrative Approach – Combining conventional oncology care with naturopathic strategies for side effect management, immune support, and recovery.
• The Role of Movement – How exercise, even in small amounts, supports treatment efficacy and recovery.
• Fasting Mimicking Diet & Microbiome Support – Evidence-backed dietary strategies during treatment and beyond.
• Mindset & Resilience – The importance of goal-setting, community support, and finding joy during and after cancer care.
• Life After Treatment – Practical steps to reduce recurrence risk and improve quality of life.

Resources & Links Mentioned:

• Book: You Finished Treatment, Now What? – Order here or at your local bookstore.
• Learn more about Dr. Amy Rothenberg: dramyrothenberg.com
• Find a licensed naturopathic doctor: naturopathic.org
• Oncology Association of Naturopathic Physicians: oncanp.org

----------------

🌱 Partner Offers

ProLon 5-Day Fasting Mimicking Diet — Enjoy fasting benefits with food. Supports cellular renewal, metabolic health, and fat loss. Special offer for our listeners: Get the ProLon kit for $148 here → https://bit.ly/3TVehAx

AG1 by Athletic Greens — 75 high-quality vitamins, minerals, probiotics, and adaptogens in one daily scoop to support your gut, immunity, energy, and focus. Try it here → https://bit.ly/3mA2tVV

💪 Exclusive Membership

Want deeper insights? Join The Dr. Geo Prostate Podcast Exclusive Membership for curated transcripts, detailed show notes, expert resources, and exclusive member perks. Join here https://drgeo.com/membership

📌 Follow and Connect

📺 YouTube → Dr. Geo Prostate Podcast / @drgeoprostatepodcast

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#CancerSurvivor #CancerRecovery #IntegrativeMedicine #NaturopathicMedicine #CancerSupport #ProstateHealth #ThrivingAfterCancer #CancerTreatment #Survivorship #CancerWellness #MensHealth #ProstateCancer #HealthTips #OncologySupport #wellnessjourney

⚠️ Disclaimer

DISCLAIMER: This audio is educational and not medical advice. The views expressed are my own and not those of my employer(s) or affiliated organizations. Use of this content is at your own risk. Geovanni Espinosa, N.D., assumes no liability for...

Are low testosterone clinics helping men—or creating more harm than good?

In this revealing episode, Dr. Geo is joined by Dr. Justin Dubin, a leading urologist and host of The Man Up Podcast, to pull back the curtain on the booming world of direct-to-consumer testosterone clinics.

Together, they explore:

• The truth behind the rise of low-T clinics
• What these businesses get right—and where they dangerously fall short
• Dr. Dubin’s undercover study: 6 out of 7 clinics offered testosterone to men who didn’t qualify
• The overlooked risks of infertility, heart issues, and priapism
• How buzzwords like “optimization” may be misleading patients
• What every man should ask before starting testosterone therapy

If you’ve been curious about TRT, overwhelmed by online advice, or simply want to make informed decisions about your hormonal health—this episode is for you.

💡 If you're facing prostate cancer surgery, concerned about erectile function, or simply fascinated by medical innovation, this episode is a must-listen.

👉 Learn more about Kyzatrex at KYZATREX.com/testing-kit.

💡 Don’t forget to subscribe, rate, and leave a review! Each review helps us reach more men who want to thrive, not just survive.

_________________________

Thank you to our July 2025 Sponsor

KYZATREX is an FDA-approved oral testosterone replacement therapy that helps restore testosterone levels back to normal. It’s not an injection or a messy gel — just a simple twice-daily pill that fits easily into your routine. Find out where you stand. Order a testing kit today at KYZATREX.com/testing-kit. Call your doctor to learn more about KYZATREX. For more information, visit www.kyzatrex.com or call 1-833-949-5040.

👉 Ask your doctor about Kyzatrex or visit KYZATREX.com/testing-kit. [https://bit.ly/4lUgY0j] to learn more.

_________________________

The ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that keep the body in a fasting state.

Special Offer: As a listener, you can get the ProLon kit for just $148 using this [https://bit.ly/3TVehAx ].

We’d also like to thank our partner AG1 by Athletic Greens. AG1 includes 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This blend supports your gut, immune system, energy, focus, and more—all in one daily scoop.

In this episode of the Dr. Geo Prostate Podcast, Dr. Geo welcomes Dr. Mohit Khera, a globally recognized leader in men’s health, Professor of Urology and Director of the Executive Health Program at Baylor College of Medicine. With over 160 peer-reviewed publications and decades of clinical experience in testosterone therapy, male infertility, and prostate health, Dr. Khera shares cutting-edge insights on testosterone replacement therapy (TRT), including the rise of oral testosterone like Kyzatrex, and the evolving understanding of testosterone’s relationship to prostate cancer.

Whether you’re considering TRT, recovering from prostate cancer, or supporting a loved one’s health journey, this conversation brings clarity to one of men’s most pressing health topics.

What You’ll Learn:

• The 4 C’s framework to determine the best TRT option:
• Cost, Compliance, Convenience, Concentration
• Why oral testosterone (Kyzatrex, Tlando, Jatenzo) is gaining traction—and what makes them different
• How Kyzatrex may help preserve fertility by reducing gonadotropin suppression
• What the TRAVERSE trial revealed about TRT and cardiovascular safety
• Why low testosterone may be linked to more aggressive prostate cancer
• What the latest science says about BAT (Bipolar Androgen Therapy) for advanced prostate cancer
• The truth about testosterone’s impact on BPH and urinary symptoms
• Why total testosterone isn't enough—labs like SHBG, DHT, estradiol, and free testosterone matter

Key Insights:

• TRT doesn’t cause prostate cancer — and may even have protective effects in some men.
• Testosterone is the best barometer of male health—predicting cardiovascular risk, mood, bone density, and more.
• BAT (Bipolar Androgen Therapy) is showing promise in treating advanced prostate cancer in specific scenarios.
• Avoid unnecessary aromatase inhibitors and DHT blockers unless clinically indicated.

💡 If you're facing prostate cancer surgery, concerned about erectile function, or simply fascinated by medical innovation, this episode is a must-listen.

👉 Learn more about Kyzatrex at KYZATREX.com/testing-kit.

💡 Don’t forget to subscribe, rate, and leave a review! Each review helps us reach more men who want to thrive, not just survive.

_________________________

Thank you to our July 2025 Sponsor

KYZATREX is an FDA-approved oral testosterone replacement therapy that helps restore testosterone levels back to normal. It’s not an injection or a messy gel — just a simple twice-daily pill that fits easily into your routine. Find out where you stand. Order a testing kit today at KYZATREX.com/testing-kit. Call your doctor to learn more about KYZATREX. For more information, visit www.kyzatrex.com or call 1-833-949-5040.

👉 Ask your doctor about Kyzatrex or visit KYZATREX.com/testing-kit. [https://bit.ly/4lUgY0j] to learn...

What if artificial intelligence could help save your erections during prostate cancer surgery?

In this groundbreaking episode of the Dr. Geo Prostate Podcast, Dr. Geo sits down with world-renowned urologist and sexual health pioneer Dr. Arthur "Bud" Burnett from Johns Hopkins. Together, they discuss an exciting new frontier in men's health: using AI and intraoperative neuromonitoring to preserve erectile function during prostate cancer surgery.

Dr. Burnett shares his four decades of experience and explains how advanced techniques — including real-time nerve mapping and AI-guided signals during surgery — are transforming outcomes for men. Imagine a future where surgeons can “see” and protect the exact nerves critical for erections, like having a GPS guiding them in real time.

They also dive into:

✅ The evolution of erectile dysfunction treatments — from Yohimbine to Viagra and beyond

✅ The history and future of penile implants, including the possibility of app-controlled devices

✅ Why nerve-sparing techniques alone may not be enough to preserve function after prostatectomy

✅ How AI and precision medicine are changing surgical outcomes and offering men more hope

Plus, Dr. Burnett discusses upcoming clinical trials and how men can potentially participate today at Johns Hopkins.

💡 If you're facing prostate cancer surgery, concerned about erectile function, or simply fascinated by medical innovation, this episode is a must-listen.

👉 Learn more about Kyzatrex at KYZATREX.com/testing-kit.

💡 Don’t forget to subscribe, rate, and leave a review! Each review helps us reach more men who want to thrive, not just survive.

_________________________

Thank you to our July 2025 Sponsor

KYZATREX is an FDA-approved oral testosterone replacement therapy that helps restore testosterone levels back to normal. It’s not an injection or a messy gel — just a simple twice-daily pill that fits easily into your routine. Find out where you stand. Order a testing kit today at KYZATREX.com/testing-kit. Call your doctor to learn more about KYZATREX. For more information, visit www.kyzatrex.com or call 1-833-949-5040.

👉 Ask your doctor about Kyzatrex or visit KYZATREX.com/testing-kit. [https://bit.ly/4lUgY0j] to learn more.

_________________________

The ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that keep the body in a fasting state.

Special Offer: As a listener, you can get the ProLon kit for just $148 using this [https://bit.ly/3TVehAx ].

We’d also like to thank our partner AG1 by Athletic Greens. AG1 includes 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This blend supports your gut, immune system, energy, focus, and more—all in one daily scoop.

Is testosterone therapy a friend or foe to your prostate? In this eye-opening episode, Dr. Geo and Dr. Thomas Masterson separate fact from fiction to help you understand the real impact of testosterone on men’s health.

Dr. Geo sits down with Dr. Thomas Masterson — a leading urologist at the University of Miami, known for his work in male infertility, sexual health, and testosterone therapy.

They take a deep dive into one of the most common and controversial questions in men’s health: Does testosterone therapy harm your prostate?

Together, they explore:

• The science behind testosterone and its impact on the prostate
• Myths vs. facts about testosterone replacement therapy (TRT)
• How testosterone affects fertility and what to know before starting TRT
• The connection between testosterone, prostate enlargement (BPH), and prostate cancer
• The latest research insights from the groundbreaking TRAVERSE trial
• Real-world patient scenarios and clinical decision-making

Dr. Masterson also shares his nuanced approach to managing patients who are on active surveillance for prostate cancer and considering testosterone therapy.

If you're curious about TRT, prostate health, or how to optimize your hormones safely, this episode is a must-listen.

👉 Learn more about Kyzatrex at KYZATREX.com/testing-kit.

💡 Don’t forget to subscribe, rate, and leave a review! Each review helps us reach more men who want to thrive, not just survive.

_________________________

Thank you to our July 2025 Sponsor

KYZATREX is an FDA-approved oral testosterone replacement therapy that helps restore testosterone levels back to normal. It’s not an injection or a messy gel — just a simple twice-daily pill that fits easily into your routine. Find out where you stand. Order a testing kit today at KYZATREX.com/testing-kit. Call your doctor to learn more about KYZATREX. For more information, visit www.kyzatrex.com or call 1-833-949-5040.

👉 Ask your doctor about Kyzatrex or visit KYZATREX.com/testing-kit. [https://bit.ly/4lUgY0j] to learn more.

_________________________

The ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that keep the body in a fasting state.

Special Offer: As a listener, you can get the ProLon kit for just $148 using this [https://bit.ly/3TVehAx ].

We’d also like to thank our partner AG1 by Athletic Greens. AG1 includes 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This blend supports your gut, immune system, energy, focus, and more—all in one daily scoop.