Reason, co-founder and CEO of Repair Biotechnologies and a longevity industry veteran with a background in astrophysics, joins us to talk about what it actually takes to test a therapy on humans, and why the system built to protect patients often keeps the best evidence hidden.

He breaks down why investors backing gene and cell therapies care more about a drug’s earning potential than whether it works, and why treatments already in use could be quietly adding years to human lifespan without anyone confirming it. Drawing on his own experience as a trial participant in Roatán, he also explains why Australia has become a faster, cheaper alternative for clinical trials, and how much of that gap comes down to culture rather than actual safety.

More about Reason’s work:

* Fight Aging!

Tim Urban, creator of Wait But Why and the mind behind one of the most-watched TED Talks of all time, joins us to talk about why progress does not happen automatically.

In this episode, he discusses the Space Race, longevity, AI safety, startup cities, and the social conditions that allow new ideas to survive. Tim explains why some technologies move fast while others stall for decades, why the best communities treat ideas like experiments, and why the future may depend less on prediction and more on building better environments for progress.

More about Tim Urban’s work:

* Tim Urban’s X

* What’s Our Problem?: A Self-Help Book for Societies

Antonio Garcia Martinez is a writer, entrepreneur, and director at Base, Coinbase’s Ethereum L2. Before that he sold a startup to Twitter, worked on ads at Facebook, and wrote Chaos Monkeys, his memoir about the early ad-tech world.

This session was recorded live in the Infinity Dome in Prospera. Antonio explains why crypto is not just a new financial system. It is a direct challenge to one of the oldest powers of the state: controlling money and deciding who owns what. If you can send USDC on Base to anyone in the room in less than a second for less than a cent, and no bank or government can stop it, the foundations of the current world start to shift.

From there, we move into the friction between digital freedom and physical geography. Antonio, Niklas and Eric talk about Próspera as a real world network state, why San Francisco stays a magnet even when it fails on the basics, and which places have the energy to become new tech hubs. Miami, Dubai, Singapore, and the American West all come up as examples. They also look at the hard questions: how to build a business model for charter cities, how the US might allow Prospera-style zones through interstate compacts, and what needs to change in education and citizenship to attract long-term residents.

This is a conversation about the future of crypto, but also about the future of how people live, build, and move. It is one of the clearest snapshots of where the network state movement is heading.

More about Antonio’s work:

* Website

* Books

* Linkedin

Explore Infinita City:

* Explore the Archive: The Infinita City Times

* Visit Infinita City

* Join the Builders’ Hub on Telegram

* Follow Infinita City on X

In this episode, the famous blogger Tomas Pueyo (Uncharted Territories) interviews Trey Goff (Chief of Staff & Head of Public Policy at Prospera) & Niklas Anzinger (Founder & CEO of Infinita City). The interview is part of the research that Tomas did for a deep piece on “The Cold Start Problem of New Cities”, as Niklas & Trey are two of the most experienced practitioners in this emerging industry. This ends up in a fascinating conversation about how new governance applied to time & place, culminating in new cities, could unlock entirely new models of human progress.

More about Tomas Pueyo’s work:

* 20 Ideas to Grow New Communities

* Tomas Pueyo’s X

More about Trey Goff’s work:

* Trey Goff’s X

In this episode, Jonathan Anomaly joins us to discuss the collapse of trust in modern institutions, the rise of tribal politics, and why liberty increasingly depends on exit rather than persuasion.We explore embryo selection, genetics, rational irrationality, startup societies, academia, media manipulation, and the future of liberalism in an age of polarization.From controversial ideas to practical entrepreneurship, this conversation dives into what happens when people stop asking permission and start building alternatives.

In this episode, we sit down with Eric Verdin, CEO of the Buck Institute, one of the world’s leading institutes dedicated to aging and longevity research.Eric has often been associated with a more rigorous and incremental approach to extending human lifespan, focused on scientific validation, measurable progress, and improving healthspan before chasing more radical ambitions. In contrast, the broader life extension movement has become known for pushing bold visions of indefinite lifespan and extreme human enhancement.But as this conversation unfolds, it becomes clear that these approaches are far less opposed than they may seem.We explore the relationship between moonshots and incremental progress, the role of scientific rigor in advancing longevity, and the institutional incentives that often reward performative radicalism over real-world results. The conversation also touches on regulation, public perception, and the challenge of turning longevity from a speculative idea into a field capable of delivering tangible benefits to people today.Rather than framing ambition and rigor as competing forces, this episode examines why both are necessary to meaningfully move the field forward.

Sid Sijbrandij is the co-founder of GitLab, one of the world’s largest open-source software companies. But in 2022, his life took a radical turn — he was diagnosed with a rare and aggressive form of cancer.

Instead of relying solely on the medical system, Sid took a different approach. He ran every diagnostic imaginable, developed experimental treatments, combined therapies, and ultimately built his own path to survival — even when doctors ran out of options.

In this episode, we explore how Sid applied first-principles thinking to medicine, why healthcare systems are fundamentally misaligned with patient incentives, and what the future of personalized treatments could look like.

Yaron Brook, chairman of the Ayn Rand Institute and host of the Yaron Brook Show, joins Niklas to discuss the moral and philosophical foundations of capitalism.

They explore Ayn Rand’s philosophy of Objectivism, the ethical case for individual freedom, and why capitalism is often misunderstood in modern political discourse. The conversation also touches on libertarian governance, free private cities, and what a truly free society could look like in practice.

A deep dive into capitalism, philosophy, and the future of human freedom.